| # | Title | Journal | Year | Citations |
|---|
| 1 | NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease | Alzheimer's and Dementia | 2018 | 5,861 |
| 2 | Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis | Science | 2006 | 5,422 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 4 | Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria | Lancet Neurology, The | 2018 | 4,605 |
| 5 | Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS | Neuron | 2011 | 4,176 |
| 6 | Classification of primary progressive aphasia and its variants | Neurology | 2011 | 3,885 |
| 7 | B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis | New England Journal of Medicine | 2008 | 2,107 |
| 8 | Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease | Nature Genetics | 2011 | 1,676 |
| 9 | A cellular gene encodes scrapie PrP 27-30 protein | Cell | 1985 | 1,490 |
| 10 | Cognition and anatomy in three variants of primary progressive aphasia | Annals of Neurology | 2004 | 1,362 |
| 11 | Embolic strokes of undetermined source: the case for a new clinical construct | Lancet Neurology, The | 2014 | 1,268 |
| 12 | NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences | Antioxidants and Redox Signaling | 2008 | 1,222 |
| 13 | Eight prion strains have PrPSc molecules with different conformations | Nature Medicine | 1998 | 1,178 |
| 14 | Scrapie prion protein contains a phosphatidylinositol glycolipid | Cell | 1987 | 1,080 |
| 15 | Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning | Science | 2009 | 1,064 |
| 16 | Common variants on chromosome 6p22.1 are associated with schizophrenia | Nature | 2009 | 1,063 |
| 17 | The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease | Nature | 2002 | 1,060 |
| 18 | Update on the Autoimmune Pathology of Multiple Sclerosis: B-Cells as Disease-Drivers and Therapeutic Targets | European Neurology | 2015 | 1,056 |
| 19 | Top-down modulation: bridging selective attention and working memory | Trends in Cognitive Sciences | 2012 | 1,049 |
| 20 | Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial | Lancet, The | 2012 | 1,030 |
| 21 | Increased Neurogenesis in the Dentate Gyrus After Transient Global Ischemia in Gerbils | Journal of Neuroscience | 1998 | 1,005 |
| 22 | Neuromyelitis optica, psychiatric symptoms and primary polydipsia: a case report | General Hospital Psychiatry | 2010 | 953 |
| 23 | Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication | Cell | 1990 | 877 |
| 24 | Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society | Epilepsy Currents | 2016 | 859 |
| 25 | miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells | BMC Medicine | 2008 | 819 |
| 26 | Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double‐blind placebo‐controlled multicenter trial | Annals of Neurology | 2009 | 815 |
| 27 | Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein | Cell | 1995 | 800 |
| 28 | Ventral tegmental area: cellular heterogeneity, connectivity and behaviour | Nature Reviews Neuroscience | 2017 | 800 |
| 29 | Astrocytes and Brain Injury | Journal of Cerebral Blood Flow and Metabolism | 2003 | 781 |
| 30 | Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders | Epilepsia | 2014 | 766 |
| 31 | Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking | Nature | 2011 | 739 |
| 32 | Abnormal Brain Development in Newborns with Congenital Heart Disease | New England Journal of Medicine | 2007 | 734 |
| 33 | Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques | Cell | 1989 | 707 |
| 34 | GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport | Nature | 2015 | 692 |
| 35 | Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity | Nature Reviews Neuroscience | 2007 | 687 |
| 36 | Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study | Lancet, The | 2018 | 684 |
| 37 | The Neurobiology of Multiple Sclerosis: Genes, Inflammation, and Neurodegeneration | Neuron | 2006 | 666 |
| 38 | Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy | Movement Disorders | 2017 | 608 |
| 39 | Episodic memory loss is related to hippocampal-mediated -amyloid deposition in elderly subjects | Brain | 2009 | 596 |
| 40 | Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial | Lancet Neurology, The | 2010 | 589 |
| 41 | Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory | Nature Neuroscience | 2011 | 564 |
| 42 | Are amyotrophic lateral sclerosis patients cognitively normal? | Neurology | 2003 | 563 |
| 43 | New insights into the regulation of protein kinase C and novel phorbol ester receptors | FASEB Journal | 1999 | 561 |
| 44 | Cytokine gene polymorphism in human disease: on-line databases | Genes and Immunity | 1999 | 560 |
| 45 | Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities | Nature Genetics | 2008 | 535 |
| 46 | Reward-Predictive Cues Enhance Excitatory Synaptic Strength onto Midbrain Dopamine Neurons | Science | 2008 | 532 |
| 47 | Acute and Chronic Cocaine-Induced Potentiation of Synaptic Strength in the Ventral Tegmental Area: Electrophysiological and Behavioral Correlates in Individual Rats | Journal of Neuroscience | 2004 | 523 |
| 48 | Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson's disease | Nature Neuroscience | 2015 | 520 |
| 49 | Incidental MRI anomalies suggestive of multiple sclerosis | Neurology | 2009 | 509 |
| 50 | Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis | Lancet Neurology, The | 2010 | 503 |
