| # | Title | Journal | Year | Citations |
|---|
| 1 | The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary | Acta Neuropathologica | 2016 | 12,144 |
| 2 | Design and validation of a histological scoring system for nonalcoholic fatty liver disease | Hepatology | 2005 | 8,518 |
| 3 | Integrative analysis of 111 reference human epigenomes | Nature | 2015 | 5,653 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 5 | The 2021 WHO Classification of Tumors of the Central Nervous System: a summary | Neuro-Oncology | 2021 | 4,534 |
| 6 | The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma | American Journal of Surgical Pathology | 2005 | 2,334 |
| 7 | DNA methylation-based classification of central nervous system tumours | Nature | 2018 | 1,872 |
| 8 | Conserved role of intragenic DNA methylation in regulating alternative promoters | Nature | 2010 | 1,568 |
| 9 | Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy | Nature Medicine | 2011 | 1,460 |
| 10 | Molecular definitions of autophagy and related processes | EMBO Journal | 2017 | 1,230 |
| 11 | Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma | JAMA Oncology | 2016 | 1,192 |
| 12 | CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages | Cancer Cell | 2009 | 1,135 |
| 13 | Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults | Nature | 2018 | 1,074 |
| 14 | Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity | Cancer Cell | 2014 | 911 |
| 15 | Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease | PLoS ONE | 2010 | 875 |
| 16 | Type 2 innate lymphoid cells control eosinophil homeostasis | Nature | 2013 | 861 |
| 17 | miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells | BMC Medicine | 2008 | 819 |
| 18 | Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration | Integrative Biology (United Kingdom) | 2015 | 772 |
| 19 | Corridors of migrating neurons in the human brain and their decline during infancy | Nature | 2011 | 741 |
| 20 | Critical Role for CD103+/CD141+ Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma | Cancer Cell | 2016 | 717 |
| 21 | Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice | Cell | 1988 | 708 |
| 22 | A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments | Nature Medicine | 2018 | 679 |
| 23 | cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV” | Acta Neuropathologica | 2018 | 599 |
| 24 | Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis | Cancer Cell | 2004 | 582 |
| 25 | Carcinoma-associated fibroblasts: orchestrating the composition of malignancy | Genes and Development | 2016 | 579 |
| 26 | IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2 | Science | 2012 | 550 |
| 27 | Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo | Journal of Experimental Medicine | 2003 | 549 |
| 28 | Regulatory T cells: recommendations to simplify the nomenclature | Nature Immunology | 2013 | 537 |
| 29 | Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity | Nature | 2017 | 530 |
| 30 | The six hyaluronidase-like genes in the human and mouse genomes | Matrix Biology | 2001 | 524 |
| 31 | Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells | Nature | 2014 | 519 |
| 32 | Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205 | Cancer Research | 2015 | 508 |
| 33 | The enemy within: keeping self-reactive T cells at bay in the periphery | Nature Reviews Immunology | 2002 | 503 |
| 34 | Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival | Molecular Biology of the Cell | 2008 | 499 |
| 35 | International Society of Neuropathology‐Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading | Brain Pathology | 2014 | 499 |
| 36 | Increased production of IL-7 accompanies HIV-1–mediated T-cell depletion: implications for T-cell homeostasis | Nature Medicine | 2001 | 498 |
| 37 | The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases | Nature Reviews Immunology | 2015 | 488 |
| 38 | Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation | Cell | 2017 | 477 |
| 39 | Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups | Acta Neuropathologica | 2011 | 474 |
| 40 | Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease | Annual Review of Pathology: Mechanisms of Disease | 2013 | 461 |
| 41 | Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility | Nature Genetics | 2009 | 456 |
| 42 | Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells | Science | 2008 | 421 |
| 43 | Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation | Molecular Biology of the Cell | 2011 | 419 |
| 44 | Does Autophagy Contribute To Cell Death? | Autophagy | 2005 | 405 |
| 45 | Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity | Cell | 2019 | 405 |
| 46 | Revisiting IL-2: Biology and therapeutic prospects | Science Immunology | 2018 | 398 |
| 47 | The behavioural/dysexecutive variant of Alzheimer’s disease: clinical, neuroimaging and pathological features | Brain | 2015 | 397 |
| 48 | Interferon γ Is Required for Activation-induced Death of T Lymphocytes | Journal of Experimental Medicine | 2002 | 392 |
| 49 | Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress | Cell | 2014 | 384 |
| 50 | Gastroesophageal Reflux Therapy Is Associated with Longer Survival in Patients with Idiopathic Pulmonary Fibrosis | American Journal of Respiratory and Critical Care Medicine | 2011 | 382 |
