| # | Title | Journal | Year | Citations |
|---|
| 1 | Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors | Science | 1992 | 3,065 |
| 2 | CRISPR–Cas12-based detection of SARS-CoV-2 | Nature Biotechnology | 2020 | 1,884 |
| 3 | RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia | Nature | 2011 | 1,656 |
| 4 | Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin | Nature Genetics | 1996 | 1,387 |
| 5 | Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin | Cell | 2014 | 1,242 |
| 6 | Lytic growth of Kaposi's sarcoma–associated herpesvirus (human herpesvirus 8) in culture | Nature Medicine | 1996 | 1,024 |
| 7 | Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity | Cancer Cell | 2014 | 911 |
| 8 | Type 2 innate lymphoid cells control eosinophil homeostasis | Nature | 2013 | 861 |
| 9 | Global epidemiology of HTLV-I infection and associated diseases | Oncogene | 2005 | 839 |
| 10 | Critical Role for CD103+/CD141+ Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma | Cancer Cell | 2016 | 717 |
| 11 | Chromosome aberrations in solid tumors | Nature Genetics | 2003 | 702 |
| 12 | A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments | Nature Medicine | 2018 | 679 |
| 13 | Reprogramming human T cell function and specificity with non-viral genome targeting | Nature | 2018 | 630 |
| 14 | CD28 Costimulation: From Mechanism to Therapy | Immunity | 2016 | 607 |
| 15 | Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis | Cell | 2015 | 565 |
| 16 | Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells | Nature Cell Biology | 2011 | 529 |
| 17 | ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 493 |
| 18 | Transfusion-related acute lung injury: incidence and risk factors | Blood | 2012 | 493 |
| 19 | Understanding the Promises and Hurdles of Metagenomic Next-Generation Sequencing as a Diagnostic Tool for Infectious Diseases | Clinical Infectious Diseases | 2018 | 488 |
| 20 | ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency | Science | 1994 | 483 |
| 21 | A genetic linkage map of the laboratory rat, Rattus norvegicus | Nature Genetics | 1995 | 477 |
| 22 | The immunomodulatory adapter proteins DAP12 and Fc receptor -chain (FcR ) regulate development of functional osteoclasts through the Syk tyrosine kinase | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 441 |
| 23 | American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer | Blood Advances | 2021 | 431 |
| 24 | A cloud-compatible bioinformatics pipeline for ultrarapid pathogen identification from next-generation sequencing of clinical samples | Genome Research | 2014 | 421 |
| 25 | Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton | Journal of Cell Biology | 2002 | 382 |
| 26 | A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen | PLoS ONE | 2010 | 356 |
| 27 | High incidence of anal high-grade squamous intra-epithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men | Aids | 1998 | 346 |
| 28 | Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway | Nature | 2020 | 343 |
| 29 | Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. | Journal of Cell Biology | 1996 | 339 |
| 30 | Tissue signals imprint ILC2 identity with anticipatory function | Nature Immunology | 2018 | 329 |
| 31 | Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids | Nature Medicine | 2021 | 329 |
| 32 | Genomic microarrays in human genetic disease and cancer | Human Molecular Genetics | 2003 | 327 |
| 33 | Human Bocaviruses Are Highly Diverse, Dispersed, Recombination Prone, and Prevalent in Enteric Infections | Journal of Infectious Diseases | 2010 | 320 |
| 34 | Pharmacokinetic/Pharmacodynamic Modeling in Drug Development | Annual Review of Pharmacology and Toxicology | 2000 | 316 |
| 35 | Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 302 |
| 36 | The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles | Nature Cell Biology | 2020 | 300 |
| 37 | Anal Cytology as a Screening Tool for Anal Squamous Intraepithelial Lesions | Journal of Acquired Immune Deficiency Syndromes | 1997 | 298 |
| 38 | Simultaneous vs. Sequential Analysis for Population PK/PD Data I: Best-Case Performance | Journal of Pharmacokinetics and Pharmacodynamics | 2003 | 297 |
| 39 | Population Pharmacokinetics/Dynamics* | Annual Review of Pharmacology and Toxicology | 1992 | 294 |
| 40 | Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12 | Nature Immunology | 2005 | 292 |
| 41 | The Fecal Virome of Pigs on a High-Density Farm | Journal of Virology | 2011 | 289 |
| 42 | Antibodies to a scrapie prion protein | Nature | 1984 | 284 |
| 43 | Comparative chromosome painting discloses homologous segments in distantly related mammals | Nature Genetics | 1994 | 284 |
| 44 | Intention-to-treat analysis and the goals of clinical trials* | Clinical Pharmacology and Therapeutics | 1995 | 284 |
| 45 | Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein | Biochimica Et Biophysica Acta Gene Regulatory Mechanisms | 2000 | 284 |
| 46 | Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development | Nature Immunology | 2003 | 277 |
| 47 | Kinase Pathways in Chemoattractant-Induced Degranulation of Neutrophils: The Role of p38 Mitogen-Activated Protein Kinase Activated by Src Family Kinases | Journal of Immunology | 2000 | 268 |
| 48 | Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas | Nature Genetics | 2001 | 268 |
| 49 | Nanopore DNA Sequencing and Genome Assembly on the International Space Station | Scientific Reports | 2017 | 264 |
| 50 | Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. | Genes and Development | 1996 | 263 |
