| # | Title | Journal | Year | Citations |
|---|
| 1 | Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria | Cell | 2009 | 3,818 |
| 2 | Acute Kidney Injury, Mortality, Length of Stay, and Costs in Hospitalized Patients | Journal of the American Society of Nephrology: JASN | 2005 | 2,887 |
| 3 | Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children | Clinical Infectious Diseases | 2011 | 2,673 |
| 4 | Signal transduction by lymphocyte antigen receptors | Cell | 1994 | 2,108 |
| 5 | The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor | Science | 1992 | 1,974 |
| 6 | Genetics of rheumatoid arthritis contributes to biology and drug discovery | Nature | 2014 | 1,974 |
| 7 | Requirement for IL-13 Independently of IL-4 in Experimental Asthma | Science | 1998 | 1,801 |
| 8 | Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network | Nature Medicine | 2019 | 1,633 |
| 9 | Current understanding of the human microbiome | Nature Medicine | 2018 | 1,593 |
| 10 | Innate Lymphoid Cells: 10 Years On | Cell | 2018 | 1,467 |
| 11 | Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children: Executive Summary | Clinical Infectious Diseases | 2011 | 1,448 |
| 12 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 13 | Clinical Course and Prediction of Survival in Idiopathic Pulmonary Fibrosis | American Journal of Respiratory and Critical Care Medicine | 2011 | 1,342 |
| 14 | New Cell Formation in Human Sebaceous Glands**From the Division of Dermatology, Department of Medicine, University of California School of Medicine, San Francisco, California. | Journal of Investigative Dermatology | 1966 | 1,319 |
| 15 | Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients | Kidney International | 2002 | 1,316 |
| 16 | Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly | Science | 1990 | 1,273 |
| 17 | Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin | Cell | 2014 | 1,242 |
| 18 | The Regulation of Immunity to Leishmania Major | Annual Review of Immunology | 1995 | 1,196 |
| 19 | Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma | Science | 2014 | 1,147 |
| 20 | Risk Factors for Lung Cancer and for Intervention Effects in CARET, the Beta-Carotene and Retinol Efficacy Trial | Journal of the National Cancer Institute | 1996 | 1,143 |
| 21 | Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci | Nature Genetics | 2010 | 1,132 |
| 22 | HIV Infection, Inflammation, Immunosenescence, and Aging | Annual Review of Medicine | 2011 | 1,109 |
| 23 | Leptin regulation of bone resorption by the sympathetic nervous system and CART | Nature | 2005 | 1,105 |
| 24 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 25 | In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes | Journal of Experimental Medicine | 2004 | 1,082 |
| 26 | Food Insecurity Is Associated with Chronic Disease among Low-Income NHANES Participants | Journal of Nutrition | 2010 | 1,081 |
| 27 | The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses | Nature Immunology | 2004 | 1,016 |
| 28 | Acute Exacerbation of Idiopathic Pulmonary Fibrosis. An International Working Group Report | American Journal of Respiratory and Critical Care Medicine | 2016 | 1,006 |
| 29 | Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse | Nature Genetics | 1999 | 971 |
| 30 | Closing the Loop | Archives of Internal Medicine | 2003 | 967 |
| 31 | Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas | Nature Genetics | 2016 | 933 |
| 32 | Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit | Nature | 2016 | 921 |
| 33 | Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry | Annals of the Rheumatic Diseases | 2020 | 908 |
| 34 | We Can Do Better — Improving the Health of the American People | New England Journal of Medicine | 2007 | 906 |
| 35 | Type 2 innate lymphoid cells control eosinophil homeostasis | Nature | 2013 | 861 |
| 36 | Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3 | Nature | 2007 | 853 |
| 37 | The Free Hormone Hypothesis: A Physiologically Based Mathematical Model* | Endocrine Reviews | 1989 | 848 |
| 38 | Clinical Presentation, Management, and In-Hospital Outcomes of Patients Admitted With Acute Decompensated Heart Failure With Preserved Systolic Function | Journal of the American College of Cardiology | 2006 | 848 |
| 39 | HPV Vaccine against Anal HPV Infection and Anal Intraepithelial Neoplasia | New England Journal of Medicine | 2011 | 810 |
| 40 | Hedgehog signalling in cancer formation and maintenance | Nature Reviews Cancer | 2003 | 785 |
| 41 | Nonalcoholic Steatohepatitis | JAMA - Journal of the American Medical Association | 2020 | 784 |
| 42 | 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus | Annals of the Rheumatic Diseases | 2019 | 759 |
| 43 | A New Risk Scheme to Predict Warfarin-Associated Hemorrhage | Journal of the American College of Cardiology | 2011 | 754 |
| 44 | Multiplexed droplet single-cell RNA-sequencing using natural genetic variation | Nature Biotechnology | 2018 | 745 |
| 45 | Cystatin C versus Creatinine in Determining Risk Based on Kidney Function | New England Journal of Medicine | 2013 | 729 |
| 46 | Tachycardia-Induced Cardiomyopathy: A Review of Animal Models and Clinical Studies | Journal of the American College of Cardiology | 1997 | 720 |
| 47 | Quasispecies Theory and the Behavior of RNA Viruses | PLoS Pathogens | 2010 | 717 |
| 48 | E-cigarettes and smoking cessation in real-world and clinical settings: a systematic review and meta-analysis | Lancet Respiratory Medicine,the | 2016 | 713 |
| 49 | A potential fusion peptide and an integrin ligand domain in a protein active in sperm–egg fusion | Nature | 1992 | 708 |
| 50 | Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. | Journal of Experimental Medicine | 1996 | 701 |
