| # | Title | Journal | Year | Citations |
|---|
| 1 | Widespread Alterations of α-Synuclein in Multiple System Atrophy | American Journal of Pathology | 1999 | 305 |
| 2 | Genetic Classification of Primary Neurodegenerative Disease | Science | 1998 | 297 |
| 3 | Three‐dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors | Protein Science | 2000 | 282 |
| 4 | Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer’s disease | Biochimica Et Biophysica Acta - Molecular Basis of Disease | 2000 | 272 |
| 5 | Accelerated filament formation from tau protein with specific FTDP-17 missense mutations | FEBS Letters | 1999 | 263 |
| 6 | Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1β or IL-1RA but increases in the associated acute phase proteins IL-6, α2-macroglobulin and C-reactive protein | Brain Research | 1993 | 258 |
| 7 | Multiple System Atrophy: A Sporadic Synucleinopathy | Brain Pathology | 1999 | 176 |
| 8 | Distinctive neuropathology revealed by α-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p | Acta Neuropathologica | 2000 | 164 |
| 9 | Substrate Binding to the Peripheral Site of Acetylcholinesterase Initiates Enzymatic Catalysis. Substrate Inhibition Arises as a Secondary Effect | Biochemistry | 1999 | 150 |
| 10 | γ-Secretase, Evidence for Multiple Proteolytic Activities and Influence of Membrane Positioning of Substrate on Generation of Amyloid β Peptides of Varying Length | Journal of Biological Chemistry | 1999 | 146 |
| 11 | Androgens modulate β-amyloid levels in male rat brain | Journal of Neurochemistry | 2004 | 123 |
| 12 | Acetylthiocholine Binds to Asp74 at the Peripheral Site of Human Acetylcholinesterase as the First Step in the Catalytic Pathway | Biochemistry | 2000 | 121 |
| 13 | Cell‐free assays for γ‐secretase activity | FASEB Journal | 2000 | 108 |
| 14 | Molecular Indices of Neuronal and Glial Plasticity in the Hippocampal Formation in a Rodent Model of Age-Induced Spatial Learning Impairment | Journal of Neuroscience | 1996 | 102 |
| 15 | Nonequilibrium Analysis Alters the Mechanistic Interpretation of Inhibition of Acetylcholinesterase by Peripheral Site Ligands† | Biochemistry | 1998 | 100 |
| 16 | Presenilin 1 Regulates Pharmacologically Distinct γ-Secretase Activities | Journal of Biological Chemistry | 2000 | 93 |
| 17 | Presence of the N-Methyl-D-Aspartate-Associated Glycine Receptor Agonist, D-Seine, in Human Temporal Cortex: Comparison of Normal, Parkinson, and Alzheimer Tissues | Journal of Neurochemistry | 1993 | 89 |
| 18 | Selective increase in cellular Aβ42 is related to apoptosis but not necrosis | NeuroReport | 2000 | 78 |
| 19 | Septo-hippocampal cholinergic and neurotrophin markers in age-induced cognitive decline | Neurobiology of Aging | 1998 | 74 |
| 20 | Relationship of the extended tau haplotype to tau biochemistry and neuropathology in progressive supranuclear palsy | Annals of Neurology | 2001 | 73 |
| 21 | Unmasking Tandem Site Interaction in Human Acetylcholinesterase. Substrate Activation with a Cationic Acetanilide Substrate† | Biochemistry | 2003 | 69 |
| 22 | Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes | NeuroReport | 2001 | 65 |
| 23 | Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus | Neurochemistry International | 1997 | 57 |
| 24 | Indicators of glial activation and brain oxidative stress after intraventricular infusion of endotoxin | Molecular Brain Research | 1998 | 54 |
| 25 | Brain Aβ amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau | Journal of Pathology | 2001 | 51 |
| 26 | Aging Blunts Ischemic-Preconditioning-Induced Neuroprotection Following Transient Global Ischemia in Rats | Current Neurovascular Research | 2005 | 51 |
| 27 | Antisense-Induced Reduction of Presenilin 1 Expression Selectively Increases the Production of Amyloid beta42 in Transfected Cells | Journal of Neurochemistry | 1999 | 47 |
| 28 | A steric blockade model for inhibition of acetylcholinesterase by peripheral site ligands and substrate | Chemico-Biological Interactions | 1999 | 46 |
| 29 | Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors | Journal of Pharmacology and Experimental Therapeutics | 1991 | 46 |
| 30 | Organophosphorylation of Acetylcholinesterase in the Presence of Peripheral Site Ligands | Journal of Biological Chemistry | 1999 | 45 |
| 31 | FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion | FEBS Letters | 1999 | 45 |
| 32 | Pharmacological characterization of the rat hippocampal muscarinic autoreceptor | Journal of Pharmacology and Experimental Therapeutics | 1993 | 45 |
| 33 | Chapter 40: Muscarinic receptor subtype-specific coupling to second messengers in neuronal systems | Progress in Brain Research | 1993 | 43 |
| 34 | Fibrillogenesis of Tau: Insights from Tau Missense Mutations in FTDP‐17 | Brain Pathology | 1999 | 43 |
| 35 | Binding and functional selectivity of himbacine for cloned and neuronal muscarinic receptors | Journal of Pharmacology and Experimental Therapeutics | 1992 | 43 |
| 36 | Differential vulnerability of primary cultured cholinergic neurons to nitric oxide excess | NeuroReport | 2000 | 41 |
| 37 | Regulation of Amyloid Precursor Protein Processing by Presenilin 1 (PS1) and PS2 in PS1 Knockout Cells | Journal of Biological Chemistry | 2000 | 41 |
| 38 | Interactions of agonists with M2 and M4 muscarinic receptor subtypes mediating cyclic AMP inhibition | Molecular Pharmacology | 1991 | 41 |
| 39 | Chronic atropine administration up-regulates rat cortical muscarinic m1 receptor mRNA molecules: assessment with the RT/PCR | Molecular Brain Research | 1992 | 39 |
| 40 | X‐linked dystonia (“Lubag”) presenting predominantly with parkinsonism: A more benign phenotype? | Movement Disorders | 2002 | 37 |
| 41 | Retinoic Acid-Mediated Enhancement of the Cholinergic/Neuronal Nitric Oxide Synthase Phenotype of the Medial Septal SN56 Clone | Journal of Neurochemistry | 2002 | 35 |
| 42 | Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer’s Disease Mouse Models | Journal of Proteome Research | 2021 | 34 |
| 43 | 1,10-Phenanthroline Inhibits Glycosylphosphatidylinositol Anchoring by Preventing Phosphoethanolamine Addition to Glycosylphosphatidylinositol Anchor Precursors† | Biochemistry | 2001 | 31 |
| 44 | Characterization of Recombinant, Soluble β-Secretase from an Insect Cell Expression System | Molecular Pharmacology | 2001 | 29 |
| 45 | mRNA for the m4 muscarinic receptor subtype is expressed in adult rat brain cholinergic neurons | Molecular Brain Research | 1997 | 25 |
| 46 | Induction of manganese superoxide dismutase in BV-2 microglial cells | NeuroReport | 1997 | 24 |
| 47 | Immunostimulation protects microglial cells from nitric oxide-mediated apoptosis | NeuroReport | 1997 | 22 |
| 48 | Selective blockade of receptor-mediated cyclic GMP formation in NIE-115 neuroblastoma cells by an inhibitor of nitric oxide synthesis | European Journal of Pharmacology | 1990 | 21 |
| 49 | The role of glutathione in nitric oxide donor toxicity to SN56 cholinergic neuron-like cells | Brain Research | 2004 | 18 |
| 50 | Aging is Neuroprotective During Global Ischemia but Leads to Increased Caspase-3 and Apoptotic Activity in Hippocampal Neurons | Current Neurovascular Research | 2006 | 17 |
