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Top Articles

#TitleJournalYearCitations
1AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Nature Cell Biology20115,447
2Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy20164,701
3Mammalian MAP kinase signalling cascadesNature20014,686
4Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent proteinNature Biotechnology20044,135
5Nuclear factor-κB in cancer development and progressionNature20063,219
6Guidelines for the use and interpretation of assays for monitoring autophagyAutophagy20123,122
7The two NF-κB activation pathways and their role in innate and adaptive immunityTrends in Immunology20042,823
8A guide to choosing fluorescent proteinsNature Methods20052,642
9Molecular dynamics simulations of biomoleculesNature Structural Biology20022,473
10AP-1 as a regulator of cell life and deathNature Cell Biology20022,448
11NF-κB in cancer: from innocent bystander to major culpritNature Reviews Cancer20022,341
12A monomeric red fluorescent proteinProceedings of the National Academy of Sciences of the United States of America20022,238
13A cytokine-responsive IκB kinase that activates the transcription factor NF-κBNature19972,056
14TEAD mediates YAP-dependent gene induction and growth controlGenes and Development20081,943
15Creating new fluorescent probes for cell biologyNature Reviews Molecular Cell Biology20021,874
16Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.Genes and Development19931,776
17The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB ActivationCell19971,723
18Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interactionCell19901,618
19AP-1 in cell proliferation and survivalOncogene20011,485
20Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1Autophagy20211,430
21Protein Kinase C: Structure, Function, and RegulationJournal of Biological Chemistry19951,388
22Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor SignalingCell20121,310
23NF‐κB and the link between inflammation and cancerImmunological Reviews20121,287
24Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinaseNature20001,283
25ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinaseNature Cell Biology20131,255
26Mechanisms of Hippo pathway regulationGenes and Development20161,224
27Regulation of TORC1 by Rag GTPases in nutrient responseNature Cell Biology20081,143
28A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCFβ-TRCPGenes and Development20101,100
29Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKKScience19941,090
30Intracellular pattern recognition receptors in the host responseNature20061,051
31The Hippo pathway: regulators and regulationsGenes and Development20131,034
32Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteinsProceedings of the National Academy of Sciences of the United States of America19981,012
33Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine ReceptorsScience19961,010
34The Hippo–YAP pathway in organ size control and tumorigenesis: an updated versionGenes and Development2010978
35The emerging roles of YAP and TAZ in cancerNature Reviews Cancer2015928
36IKK-γ is an essential regulatory subunit of the IκB kinase complexNature1998915
37Improving the photostability of bright monomeric orange and red fluorescent proteinsNature Methods2008915
38Regulation of protein kinase CCurrent Opinion in Cell Biology1997900
39The mammalian ultraviolet response is triggered by activation of src tyrosine kinasesCell1992893
40Protein Kinase C:  Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular InteractionsChemical Reviews2001884
41The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signallingSeminars in Immunology2000877
42Circular permutation and receptor insertion within green fluorescent proteinsProceedings of the National Academy of Sciences of the United States of America1999859
43NF-κB Restricts Inflammasome Activation via Elimination of Damaged MitochondriaCell2016859
44The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB PathwaysImmunity2002842
45Positive and Negative Regulation of IB Kinase Activity Through IKK Subunit PhosphorylationScience1999823
46Engineering a memory with LTD and LTPNature2014822
47TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo PathwayMolecular and Cellular Biology2008805
48Mass spectral molecular networking of living microbial coloniesProceedings of the National Academy of Sciences of the United States of America2012804
49Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73Nature1991801
50Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKK Subunit of IB KinaseScience1999799