| # | Title | Journal | Year | Citations |
|---|
| 1 | Design and validation of a histological scoring system for nonalcoholic fatty liver disease | Hepatology | 2005 | 8,518 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Dopaminergic Loss and Inclusion Body Formation in -Synuclein Mice: Implications for Neurodegenerative Disorders | Science | 2000 | 1,691 |
| 4 | Tumor angiogenesis: molecular pathways and therapeutic targets | Nature Medicine | 2011 | 1,518 |
| 5 | Detecting Individual Sites Subject to Episodic Diversifying Selection | PLoS Genetics | 2012 | 1,455 |
| 6 | The many faces of α-synuclein: from structure and toxicity to therapeutic target | Nature Reviews Neuroscience | 2013 | 1,322 |
| 7 | Rapid evolution of the neutralizing antibody response to HIV type 1 infection | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 1,113 |
| 8 | Automated Phylogenetic Detection of Recombination Using a Genetic Algorithm | Molecular Biology and Evolution | 2006 | 866 |
| 9 | Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73 | Nature | 1991 | 801 |
| 10 | GARD: a genetic algorithm for recombination detection | Bioinformatics | 2006 | 750 |
| 11 | New mitochondrial DNA synthesis enables NLRP3 inflammasome activation | Nature | 2018 | 722 |
| 12 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers | Cell | 2020 | 691 |
| 13 | The Genetic Landscape of the Childhood Cancer Medulloblastoma | Science | 2011 | 652 |
| 14 | α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress | American Journal of Pathology | 2000 | 641 |
| 15 | The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity | Nature | 1987 | 638 |
| 16 | Traumatic Brain Injury and Intestinal Dysfunction: Uncovering the Neuro-Enteric Axis | Journal of Neurotrauma | 2009 | 597 |
| 17 | Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene | Science | 1990 | 591 |
| 18 | Inactivation of the retinoblastoma susceptibility gene in human breast cancers | Science | 1988 | 572 |
| 19 | Reversed‐phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells | Proteomics | 2011 | 564 |
| 20 | Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma | Nature | 2014 | 520 |
| 21 | Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease | Gastroenterology | 2017 | 510 |
| 22 | Tumor Necrosis Factor-α Induces Mechanical Allodynia after Spinal Nerve Ligation by Activation of p38 MAPK in Primary Sensory Neurons | Journal of Neuroscience | 2003 | 497 |
| 23 | Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease | Nature | 2019 | 493 |
| 24 | Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy | Nature | 2015 | 451 |
| 25 | Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease | Journal of Pediatrics | 2003 | 446 |
| 26 | Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours | European Journal of Cancer | 2002 | 442 |
| 27 | Differential neuropathological alterations in transgenic mice expressing ?-synuclein from the platelet-derived growth factor and Thy-1 promoters | Journal of Neuroscience Research | 2002 | 441 |
| 28 | The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. | Journal of Experimental Medicine | 1994 | 437 |
| 29 | Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 429 |
| 30 | Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 427 |
| 31 | Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue | Nature Communications | 2019 | 411 |
| 32 | Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases | NeuroMolecular Medicine | 2003 | 410 |
| 33 | Ligand-induced transformation by a noninternalizing epidermal growth factor receptor | Science | 1990 | 405 |
| 34 | NUP98–NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis | Nature Cell Biology | 2007 | 395 |
| 35 | Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer | Cell | 2015 | 394 |
| 36 | Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease | PLoS ONE | 2011 | 375 |
| 37 | p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells | Cancer Cell | 2016 | 353 |
| 38 | Differences Between Vascular and Plaque Core Amyloid in Alzheimer's Disease | Journal of Neurochemistry | 1988 | 347 |
| 39 | Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines | Nature Immunology | 2010 | 343 |
| 40 | Monoclonal antibodies to murine hepatitis virus-4 (strain JHM) define the viral glycoprotein responsible for attachment and cell-cell fusion | Virology | 1982 | 338 |
| 41 | Pathophysiology of Placenta Creta: The Role of Decidua and Extravillous Trophoblast | Placenta | 2008 | 335 |
| 42 | Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy | PLoS ONE | 2010 | 327 |
| 43 | Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 313 |
| 44 | Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells | Nature Cell Biology | 2018 | 306 |
| 45 | Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma | Nature Reviews Cancer | 2015 | 305 |
| 46 | The Biomechanical and Biochemical Properties of Swine Tendons — Long Term Effects of Exercise on the Digital Extensors | Connective Tissue Research | 1980 | 301 |
| 47 | Ezetimibe for the treatment of nonalcoholic steatohepatitis: Assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial) | Hepatology | 2015 | 296 |
| 48 | Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation | Nature Cell Biology | 2016 | 291 |
| 49 | A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target | Nature Medicine | 2012 | 290 |
| 50 | The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis | Cancer Immunology Research | 2016 | 290 |
