| # | Title | Journal | Year | Citations |
|---|
| 1 | Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis | Lancet Neurology, The | 2015 | 2,776 |
| 2 | A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease | Nature Medicine | 2005 | 979 |
| 3 | Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury | Cell | 2012 | 760 |
| 4 | Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition | Science | 1992 | 672 |
| 5 | Arterial Pressure–Based Cardiac Output Assessment | Journal of Cardiothoracic and Vascular Anesthesia | 2008 | 610 |
| 6 | Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury | Nature Medicine | 2010 | 487 |
| 7 | Biomimetic 3D-printed scaffolds for spinal cord injury repair | Nature Medicine | 2019 | 460 |
| 8 | Formalin-evoked activity in identified primary afferent fibers: systemic lidocaine suppresses phase-2 activity | Pain | 1996 | 429 |
| 9 | Endoneurial injection of TNF-α produces neuropathic pain behaviors | NeuroReport | 1996 | 414 |
| 10 | Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules | Annual Review of Pharmacology and Toxicology | 2008 | 399 |
| 11 | Pain after breast surgery: a survey of 282 women | Pain | 1996 | 374 |
| 12 | Injury Type-Specific Calcium Channel α2δ-1 Subunit Up-Regulation in Rat Neuropathic Pain Models Correlates with Antiallodynic Effects of Gabapentin | Journal of Pharmacology and Experimental Therapeutics | 2002 | 372 |
| 13 | ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43 | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 370 |
| 14 | Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats | Pain | 1993 | 359 |
| 15 | Comparison of the Antinociceptive Effects of Pre- and Posttreatment with Intrathecal Morphine and MK801, an NMDA Antagonist, on the Formalin Test in the Rat | Anesthesiology | 1992 | 339 |
| 16 | The Association Between Lower Extremity Continuous Peripheral Nerve Blocks and Patient Falls After Knee and Hip Arthroplasty | Anesthesia and Analgesia | 2010 | 331 |
| 17 | Cell-Surface Marker Signatures for the Isolation of Neural Stem Cells, Glia and Neurons Derived from Human Pluripotent Stem Cells | PLoS ONE | 2011 | 317 |
| 18 | Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats | Journal of Neuroscience | 1995 | 285 |
| 19 | Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists | Pain | 1992 | 280 |
| 20 | The Acute Antihyperalgesic Action of Nonsteroidal, Anti-Inflammatory Drugs and Release of Spinal Prostaglandin E2Is Mediated by the Inhibition of Constitutive Spinal Cyclooxygenase-2 (COX-2) but not COX-1 | Journal of Neuroscience | 2001 | 274 |
| 21 | The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat | Pain | 1997 | 240 |
| 22 | Effects of Propofol, Etomidate, Midazolam, and Fentanyl on Motor Evoked Responses to Transcranial Electrical or Magnetic Stimulation in Humans | Anesthesiology | 1992 | 232 |
| 23 | MAC of sevoflurane in humans and the New Zealand white rabbit | Canadian Journal of Anaesthesia | 1988 | 227 |
| 24 | Nociceptive and inflammatory effects of subcutaneous TNF α | Pain | 2000 | 211 |
| 25 | Changes in Extracellular Concentrations of Glutamate, Aspartate, Glycine, Dopamine, Serotonin, and Dopamine Metabolites After Transient Global Ischemia in the Rabbit Brain | Journal of Neurochemistry | 1991 | 209 |
| 26 | Continuous Peripheral Nerve Blocks: An Update of the Published Evidence and Comparison With Novel, Alternative Analgesic Modalities | Anesthesia and Analgesia | 2017 | 209 |
| 27 | Ambulatory Continuous Femoral Nerve Blocks Decrease Time to Discharge Readiness after Tricompartment Total Knee Arthroplasty | Anesthesiology | 2008 | 205 |
| 28 | Effect of continuous intrathecal infusion of ω-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats | Pain | 1995 | 203 |
| 29 | ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS | Neuron | 2018 | 185 |
| 30 | Magnetic targeting of nanoparticles across the intact blood–brain barrier | Journal of Controlled Release | 2012 | 183 |
| 31 | Rapid continuous 3D printing of customizable peripheral nerve guidance conduits | Materials Today | 2018 | 173 |
| 32 | Hydrogen Sulfide—Mechanisms of Toxicity and Development of an Antidote | Scientific Reports | 2016 | 170 |
| 33 | The effect of ethnicity on prescriptions for patient-controlled analgesia for post-operative pain | Pain | 1996 | 168 |
| 34 | Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model | Neuroscience Letters | 1995 | 166 |
| 35 | Concentration–Effect Relationship of Intravenous Lidocaine on the Allodynia of Complex Regional Pain Syndrome Types I and II | Anesthesiology | 2000 | 163 |
| 36 | Inflammatory Masses Associated with Intrathecal Drug Infusion: A Review of Preclinical Evidence and Human Data | Pain Medicine | 2002 | 163 |
| 37 | Chronically Infused Intrathecal Morphine in Dogs | Anesthesiology | 2003 | 163 |
| 38 | A brief comparison of the pathophysiology of inflammatory versus neuropathic pain | Current Opinion in Anaesthesiology | 2011 | 160 |
| 39 | Local Cerebral Blood Flow and Glucose Utilization during Isoflurane Anesthesia in the Rat | Anesthesiology | 1986 | 158 |
| 40 | Effect of subarachnoid gabapentin on tactile-evoked allodynia in a surgically induced neuropathic pain model in the ratठ| Regional Anesthesia and Pain Medicine | 1997 | 158 |
| 41 | A Comparison of the Cerebral Protective Effects of Isoflurane and Barbiturates during Temporary Focal Ischemia in Primates | Anesthesiology | 1987 | 157 |
| 42 | A Comparison of the Cerebral Protective Effects of Isoflurane and Mild Hypothermia in a Model of Incomplete Forebrain Ischemia in the Rat | Anesthesiology | 1992 | 156 |
| 43 | Loss of Caveolin-1 Accelerates Neurodegeneration and Aging | PLoS ONE | 2010 | 155 |
| 44 | Systemic Lidocaine Blocks Nerve Injury-induced Hyperalgesia and Nociceptor-driven Spinal Sensitization in the Rat | Anesthesiology | 1994 | 154 |
| 45 | Axonal transport of TNF-α in painful neuropathy: distribution of ligand tracer and TNF receptors | Journal of Neuroimmunology | 2001 | 152 |
| 46 | Hypothermia prevents ischemia-induced increases in hippocampal glycine concentrations in rabbits. | Stroke | 1991 | 150 |
| 47 | The spinal loop dialysis catheter: characterization of use in the unanesthetized rat | Journal of Neuroscience Methods | 1995 | 148 |
| 48 | Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior | Pain | 2010 | 140 |
| 49 | Endotracheal intubation versus supraglottic airway insertion in out-of-hospital cardiac arrest | Resuscitation | 2012 | 140 |
| 50 | Comparison of Conventional Surgical versus Seldinger Technique Emergency Cricothyrotomy Performed by Inexperienced Clinicians | Anesthesiology | 2000 | 139 |
