| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | A SARS-CoV-2 protein interaction map reveals targets for drug repurposing | Nature | 2020 | 3,542 |
| 3 | Macrophages, Inflammation, and Insulin Resistance | Annual Review of Physiology | 2010 | 2,279 |
| 4 | Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study | Intensive Care Medicine | 2015 | 1,838 |
| 5 | Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ | Nature | 1998 | 1,818 |
| 6 | Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers | Molecular Cancer Therapeutics | 2017 | 1,779 |
| 7 | Crohn's disease | Lancet, The | 2012 | 1,722 |
| 8 | MicroRNA-133 controls cardiac hypertrophy | Nature Medicine | 2007 | 1,652 |
| 9 | IKK-β links inflammation to obesity-induced insulin resistance | Nature Medicine | 2005 | 1,591 |
| 10 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes | Nature | 2007 | 1,565 |
| 11 | Detecting Individual Sites Subject to Episodic Diversifying Selection | PLoS Genetics | 2012 | 1,455 |
| 12 | Normalization and microbial differential abundance strategies depend upon data characteristics | Microbiome | 2017 | 1,434 |
| 13 | Isl1 Identifies a Cardiac Progenitor Population that Proliferates Prior to Differentiation and Contributes a Majority of Cells to the Heart | Developmental Cell | 2003 | 1,433 |
| 14 | Low density lipoprotein undergoes oxidative modification in vivo. | Proceedings of the National Academy of Sciences of the United States of America | 1989 | 1,406 |
| 15 | The cellular and signaling networks linking the immune system and metabolism in disease | Nature Medicine | 2012 | 1,321 |
| 16 | The oxidation hypothesis of atherosclerosis | Lancet, The | 1994 | 1,274 |
| 17 | From charcot to lou gehrig: deciphering selective motor neuron death in als | Nature Reviews Neuroscience | 2001 | 1,264 |
| 18 | Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030 | Journal of Hepatology | 2018 | 1,157 |
| 19 | A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ | Nature | 2005 | 1,125 |
| 20 | Antiretroviral-Drug Resistance among Patients Recently Infected with HIV | New England Journal of Medicine | 2002 | 1,104 |
| 21 | Chemical Diversity in the Sialic Acids and Related α-Keto Acids: An Evolutionary Perspective | Chemical Reviews | 2002 | 1,102 |
| 22 | A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. | Journal of Clinical Investigation | 1995 | 1,098 |
| 23 | Treatment of Atrial Fibrillation by the Ablation of Localized Sources | Journal of the American College of Cardiology | 2012 | 1,033 |
| 24 | Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. | Proceedings of the National Academy of Sciences of the United States of America | 1987 | 981 |
| 25 | Insulin sensitivity: modulation by nutrients and inflammation | Journal of Clinical Investigation | 2008 | 980 |
| 26 | Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia | Journal of Experimental Medicine | 2001 | 978 |
| 27 | Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury | Critical Care | 2013 | 969 |
| 28 | Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup | Nature Reviews Nephrology | 2017 | 946 |
| 29 | Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics | Nature Cell Biology | 1999 | 937 |
| 30 | Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients | Nature | 1990 | 921 |
| 31 | Microglial cell origin and phenotypes in health and disease | Nature Reviews Immunology | 2011 | 897 |
| 32 | Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury | Kidney International | 2009 | 888 |
| 33 | The final steps of integrin activation: the end game | Nature Reviews Molecular Cell Biology | 2010 | 888 |
| 34 | Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants | Nature Medicine | 1997 | 884 |
| 35 | Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease | Gastroenterology | 2019 | 882 |
| 36 | Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 859 |
| 37 | NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria | Cell | 2016 | 859 |
| 38 | Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity | Cell | 2017 | 858 |
| 39 | Small Interfering RNA-Induced Transcriptional Gene Silencing in Human Cells | Science | 2004 | 857 |
| 40 | Immunomodulatory functions of type I interferons | Nature Reviews Immunology | 2012 | 843 |
| 41 | Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 822 |
| 42 | Interactions Between the Intestinal Microbiome and Liver Diseases | Gastroenterology | 2014 | 806 |
| 43 | MLP-Deficient Mice Exhibit a Disruption of Cardiac Cytoarchitectural Organization, Dilated Cardiomyopathy, and Heart Failure | Cell | 1997 | 790 |
| 44 | Biological Network Exploration with Cytoscape 3 | Current Protocols in Bioinformatics | 2014 | 780 |
| 45 | International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology | Lancet, The | 2015 | 780 |
| 46 | Epithelial antimicrobial defence of the skin and intestine | Nature Reviews Immunology | 2012 | 779 |
| 47 | Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury. | Journal of Clinical Investigation | 1995 | 777 |
| 48 | Tuberculosis in Patients with Human Immunodeficiency Virus Infection | New England Journal of Medicine | 1999 | 770 |
| 49 | The Chromogranin–Secretogranin Family | New England Journal of Medicine | 2003 | 770 |
| 50 | Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family | Journal of Biological Chemistry | 1998 | 766 |
