| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data | Neuroscience Letters | 2003 | 3,295 |
| 3 | Clonogenic assay of cells in vitro | Nature Protocols | 2006 | 3,193 |
| 4 | Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria | Nature | 1994 | 3,138 |
| 5 | Histone deacetylases (HDACs): characterization of the classical HDAC family | Biochemical Journal | 2003 | 2,671 |
| 6 | ESMO consensus guidelines for the management of patients with metastatic colorectal cancer | Annals of Oncology | 2016 | 2,545 |
| 7 | Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica | Science | 2008 | 2,289 |
| 8 | STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies | BMJ, The | 2015 | 1,914 |
| 9 | Glucose tolerance in adults after prenatal exposure to famine | Lancet, The | 1998 | 1,427 |
| 10 | Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies | Lancet, The | 2002 | 1,415 |
| 11 | STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration | BMJ Open | 2016 | 1,324 |
| 12 | The incidence and nature of in-hospital adverse events: a systematic review | Quality and Safety in Health Care | 2008 | 1,319 |
| 13 | Dendritic-cell control of pathogen-driven T-cell polarization | Nature Reviews Immunology | 2003 | 1,235 |
| 14 | Grading quality of evidence and strength of recommendations for diagnostic tests and strategies | BMJ: British Medical Journal | 2008 | 1,119 |
| 15 | Treatment of Venous Thrombosis with Intravenous Unfractionated Heparin Administered in the Hospital as Compared with Subcutaneous Low-Molecular-Weight Heparin Administered at Home | New England Journal of Medicine | 1996 | 1,108 |
| 16 | Prediction of poor outcome within the first 3 days of postanoxic coma | Neurology | 2006 | 1,055 |
| 17 | Obesity at the age of 50 y in men and women exposed to famine prenatally | American Journal of Clinical Nutrition | 1999 | 1,034 |
| 18 | Randomised trial of self-expanding metal stents versus polyethylene stents for distal malignant biliary obstruction | Lancet, The | 1992 | 1,016 |
| 19 | Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas | Lancet Oncology, The | 2008 | 990 |
| 20 | The Development and Validation of an Endoscopic Grading System for Barrett’s Esophagus: The Prague C & M Criteria | Gastroenterology | 2006 | 931 |
| 21 | Mapping genomic loci implicates genes and synaptic biology in schizophrenia | Nature | 2022 | 929 |
| 22 | Panethnic Differences in Blood Pressure in Europe: A Systematic Review and Meta-Analysis | PLoS ONE | 2016 | 882 |
| 23 | Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects | Nature Genetics | 2017 | 838 |
| 24 | T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal | Trends in Immunology | 1999 | 830 |
| 25 | Sepsis: a roadmap for future research | Lancet Infectious Diseases, The | 2015 | 827 |
| 26 | Chronic rhinosinusitis in Europe - an underestimated disease. A GA2LEN study | Allergy: European Journal of Allergy and Clinical Immunology | 2011 | 778 |
| 27 | The Phosphatidylinositol 3-Kinase Inhibitors Wortmannin and LY294002 Inhibit Autophagy in Isolated Rat Hepatocytes | FEBS Journal | 1997 | 762 |
| 28 | Treatable traits: toward precision medicine of chronic airway diseases | European Respiratory Journal | 2016 | 746 |
| 29 | SOCS3 negatively regulates IL-6 signaling in vivo | Nature Immunology | 2003 | 743 |
| 30 | Borderline resectable pancreatic cancer: A consensus statement by the International Study Group of Pancreatic Surgery (ISGPS) | Surgery | 2014 | 736 |
| 31 | Definition of treatment goals for moderate to severe psoriasis: a European consensus | Archives of Dermatological Research | 2011 | 690 |
| 32 | Prenatal exposure to the Dutch famine and disease in later life: An overview | Reproductive Toxicology | 2005 | 686 |
| 33 | Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy | Neuroscience and Biobehavioral Reviews | 2020 | 681 |
| 34 | Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial | Lancet, The | 2003 | 655 |
| 35 | Venous thromboembolism in childhood: A prospective two-year registry in The Netherlands | Journal of Pediatrics | 2001 | 640 |
| 36 | Corticosteroid injections, physiotherapy, or a wait-and-see policy for lateral epicondylitis: a randomised controlled trial | Lancet, The | 2002 | 640 |
| 37 | Guidelines on management (diagnosis and treatment) of syncope | European Heart Journal | 2001 | 638 |
| 38 | Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma | Lancet, The | 1998 | 632 |
| 39 | Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions | Journal of Antimicrobial Chemotherapy | 2000 | 617 |
| 40 | Pathogenesis, treatment, and prevention of pneumococcal pneumonia | Lancet, The | 2009 | 611 |
| 41 | The prevalence of severe refractory asthma | Journal of Allergy and Clinical Immunology | 2015 | 582 |
| 42 | Changes in the volume status of haemodialysis patients are reflected in sublingual microvascular perfusion | Nephrology Dialysis Transplantation | 2009 | 569 |
| 43 | Chronic Granulomatous Disease: The European Experience | PLoS ONE | 2009 | 567 |
| 44 | Coronary heart disease after prenatal exposure to the Dutch famine, 1944-45 | British Heart Journal | 2000 | 563 |
| 45 | Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury | PLoS Pathogens | 2015 | 532 |
| 46 | The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study | Lancet Psychiatry,the | 2019 | 528 |
| 47 | Pharmacological strategies to decrease excessive blood loss in cardiac surgery: a meta-analysis of clinically relevant endpoints | Lancet, The | 1999 | 527 |
| 48 | Carnitine biosynthesis in mammals | Biochemical Journal | 2002 | 527 |
| 49 | The immunology of acute stroke | Nature Reviews Neurology | 2012 | 527 |
| 50 | Treatment of osteochondral lesions of the talus: a systematic review | Knee Surgery, Sports Traumatology, Arthroscopy | 2010 | 512 |
