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exaly
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Department of Pharmacology
›
top-articles
Department of Pharmacology
282
(top 1%)
papers
10.2K
(top 1%)
citations
54
(top 1%)
h
-index
91
(top 1%)
g
-index
315
all documents
11.3K
doc citations
1.9K
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells
Cell Stem Cell
2013
584
2
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation
Nature
2013
495
3
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases
Nature Biotechnology
2007
492
4
β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
Science
2017
341
5
The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart
Cell Reports
2015
284
6
CaMKII binding to GluN2B is critical during memory consolidation
EMBO Journal
2012
207
7
CaMKII in the Cardiovascular System: Sensing Redox States
Physiological Reviews
2011
192
8
A comprehensive ChIP–chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members
Genome Research
2007
190
9
The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction
Journal of Molecular and Cellular Cardiology
2016
181
10
Transmembrane Traffic in the Cytochromeb6fComplex
Annual Review of Biochemistry
2006
177
11
Genome-Wide Analysis of KAP1 Binding Suggests Autoregulation of KRAB-ZNFs
PLoS Genetics
2007
166
12
FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility
Nature Communications
2017
166
13
Ca
2+
spark-dependent and -independent sarcoplasmic reticulum Ca
2+
leak in normal and failing rabbit ventricular myocytes
Journal of Physiology
2010
155
14
Activity-Dependent Growth of New Dendritic Spines Is Regulated by the Proteasome
Neuron
2012
147
15
Epac2 Mediates Cardiac β1-Adrenergic–Dependent Sarcoplasmic Reticulum Ca
2+
Leak and Arrhythmia
Circulation
2013
145
16
Ion Channels in the Heart
2015
135
17
Empagliflozin Ameliorates Obesity-Related Cardiac Dysfunction by Regulating Sestrin2-Mediated AMPK-mTOR Signaling and Redox Homeostasis in High-Fat Diet–Induced Obese Mice
Diabetes
2020
121
18
Antibodies and venom peptides: new modalities for ion channels
Nature Reviews Drug Discovery
2019
119
19
Hyperamylinemia Contributes to Cardiac Dysfunction in Obesity and Diabetes
Circulation Research
2012
113
20
Fentanyl-Related Deaths: Demographics, Circumstances, and Toxicology of 112 Cases
Journal of Forensic Sciences
1991
110
21
Arrhythmogenic Effects of β
2
-Adrenergic Stimulation in the Failing Heart Are Attributable to Enhanced Sarcoplasmic Reticulum Ca Load
Circulation Research
2008
98
22
Inhibiting Insulin-Mediated β
2
-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction
Circulation
2017
98
23
Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels
ELife
2015
97
24
A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na
+
loading and CaMKII
Journal of Physiology
2014
96
25
GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells
ELife
2018
96
26
Chemokine Receptor Antagonists
Journal of Medicinal Chemistry
2012
92
27
CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy
Journal of Molecular and Cellular Cardiology
2019
92
28
Dynamic Calcium Movement Inside Cardiac Sarcoplasmic Reticulum During Release
Circulation Research
2011
91
29
The lymphocyte potassium channels Kv1.3 and KCa3.1 as targets for immunosuppression
Drug Development Research
2011
88
30
KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis
Nature Communications
2015
83
31
Fluorescence Resonance Energy Transfer–Based Sensor Camui Provides New Insight Into Mechanisms of Calcium/Calmodulin-Dependent Protein Kinase II Activation in Intact Cardiomyocytes
Circulation Research
2011
82
32
β2 Adrenergic Receptor, Protein Kinase A (PKA) and c-Jun N-terminal Kinase (JNK) Signaling Pathways Mediate Tau Pathology in Alzheimer Disease Models
Journal of Biological Chemistry
2013
81
33
Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy
Journal of Medicinal Chemistry
2014
81
34
Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias
American Journal of Physiology - Heart and Circulatory Physiology
2013
80
35
Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS)
PLoS ONE
2015
79
36
Mechanisms Restricting Diffusion of Intracellular cAMP
Scientific Reports
2016
79
37
Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer’s disease: preclinical proof of concept
Brain
2018
79
38
Chasing cardiac physiology and pathology down the CaMKII cascade
American Journal of Physiology - Heart and Circulatory Physiology
2015
78
39
Na+/K+-ATPase 2-isoform preferentially modulates Ca2+ transients and sarcoplasmic reticulum Ca2+ release in cardiac myocytes
Cardiovascular Research
2012
77
40
Cardiac Stem Cell Hybrids Enhance Myocardial Repair
Circulation Research
2015
77
41
Size Matters: Ryanodine Receptor Cluster Size Affects Arrhythmogenic Sarcoplasmic Reticulum Calcium Release
Journal of the American Heart Association
2018
76
42
Mutations in AKAP5 Disrupt Dendritic Signaling Complexes and Lead to Electrophysiological and Behavioral Phenotypes in Mice
PLoS ONE
2010
75
43
Role of Membrane Microdomains in Compartmentation of cAMP Signaling
PLoS ONE
2014
75
44
Mitochondrial free calcium regulation during sarcoplasmic reticulum calcium release in rat cardiac myocytes
Journal of Molecular and Cellular Cardiology
2009
74
45
Why CCR2 and CCR5 Blockade Failed and Why CCR1 Blockade Might Still Be Effective in the Treatment of Rheumatoid Arthritis
PLoS ONE
2011
72
46
The Class II Phosphatidylinositol 3 kinase C2β Is Required for the Activation of the K
+
Channel KCa3.1 and CD4 T-Cells
Molecular Biology of the Cell
2009
68
47
General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA
In Silico
Strategy
Clinical Pharmacology and Therapeutics
2020
67
48
β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets
Journal of Molecular and Cellular Cardiology
2013
66
49
Epac enhances excitation–transcription coupling in cardiac myocytes
Journal of Molecular and Cellular Cardiology
2012
64
50
Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation
Science Signaling
2019
63
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