| # | Title | Journal | Year | Citations |
|---|
| 1 | A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease | Nature Medicine | 2005 | 979 |
| 2 | Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain | Brain Research | 1996 | 834 |
| 3 | Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial | Lancet Neurology, The | 2007 | 610 |
| 4 | Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer's disease | Neurology | 1991 | 407 |
| 5 | The neurobiology of cognitive disorders in temporal lobe epilepsy | Nature Reviews Neurology | 2011 | 398 |
| 6 | Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan | Lancet, The | 2012 | 366 |
| 7 | Conformationally defined neurotransmitter analogs. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer | Journal of Medicinal Chemistry | 1991 | 304 |
| 8 | NMDA Receptor Activation Produces Concurrent Generation of Nitric Oxide and Reactive Oxygen Species: Implications for Cell Death | Journal of Neurochemistry | 1995 | 253 |
| 9 | Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism | European Journal of Pharmacology | 1995 | 231 |
| 10 | The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-λ, tumor necrosis factor α, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation | Journal of Neuroimmunology | 1989 | 223 |
| 11 | Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease | Neurobiology of Aging | 2011 | 223 |
| 12 | The Remarkable Coding Strategy of Borna Disease Virus: A New Member of the Nonsegmented Negative Strand RNA Viruses | Virology | 1995 | 206 |
| 13 | Prevalence of dementia after age 90 | Neurology | 2008 | 191 |
| 14 | Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease | JAMA Neurology | 2014 | 166 |
| 15 | Pathology and physiology of auditory neuropathy with a novel mutation in the MPZ gene (Tyr145->Ser) | Brain | 2003 | 158 |
| 16 | Generation of auditory brain stem responses (ABRs). III. Effects of lesions of the superior olive, lateral lemniscus and inferior colliculus on the ABR in guinea pig | Electroencephalography and Clinical Neurophysiology | 1983 | 151 |
| 17 | Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans | Nature Communications | 2019 | 149 |
| 18 | AMPA/kainate receptor-triggered Zn2+entry into cortical neurons induces mitochondrial Zn2+uptake and persistent mitochondrial dysfunction | European Journal of Neuroscience | 2000 | 140 |
| 19 | Magnetic resonance imaging analysis of age‐related changes in the brains of individuals with Down's syndrome | Neurology | 1994 | 132 |
| 20 | Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old | Brain | 2014 | 132 |
| 21 | Age of onset of hypertension and risk of dementia in the oldest‐old: The 90+ Study | Alzheimer's and Dementia | 2017 | 132 |
| 22 | Reduced risk of Alzheimer's disease with high folate intake: The Baltimore Longitudinal Study of Aging | Alzheimer's and Dementia | 2005 | 131 |
| 23 | A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals? | Hippocampus | 2017 | 130 |
| 24 | Familial Alzheimer’s Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-β Peptide | Journal of Biological Chemistry | 2017 | 123 |
| 25 | Dentition, Dental Health Habits, and Dementia: The Leisure World Cohort Study | Journal of the American Geriatrics Society | 2012 | 116 |
| 26 | Visuospatial function in the beagle dog: An early marker of cognitive decline in a model of human aging and dementia | Neurobiology of Learning and Memory | 2006 | 115 |
| 27 | Evoked potential correlates of human information processing | Biological Psychology | 1979 | 112 |
| 28 | Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo | Journal of Neuroscience | 1995 | 112 |
| 29 | Non-Alzheimer’s contributions to dementia and cognitive resilience in The 90+ Study | Acta Neuropathologica | 2018 | 112 |
| 30 | Improved understanding of cortical injury by incorporating measures of functional anatomy | Brain | 2003 | 111 |
| 31 | Caspase-Mediated Cleavage of Glial Fibrillary Acidic Protein within Degenerating Astrocytes of the Alzheimer's Disease Brain | American Journal of Pathology | 2006 | 111 |
| 32 | Generation of auditory brain stem responses (ABRs). I. Effects of injection of a local anesthetic (procaine HCl) into the trapezoid body of guinea pigs and cat | Electroencephalography and Clinical Neurophysiology | 1983 | 109 |
| 33 | Current management of spontaneous intracerebral haemorrhage | Stroke and Vascular Neurology | 2017 | 108 |
| 34 | Zn 2+ currents are mediated by calcium‐permeable AMPA/Kainate channels in cultured murine hippocampal neurones | Journal of Physiology | 2002 | 106 |
| 35 | Genetic Variation in the Human Brain Dopamine System Influences Motor Learning and Its Modulation by L-Dopa | PLoS ONE | 2013 | 106 |
| 36 | B Lymphocyte Autoimmunity in Rheumatoid Synovitis Is Independent of Ectopic Lymphoid Neogenesis | Journal of Immunology | 2008 | 102 |
| 37 | Generation of auditory brain stem responses (ABRs). II. Effects of surgical section of the trapezoid body on the ABR in guinea pigs and cat | Electroencephalography and Clinical Neurophysiology | 1983 | 101 |
| 38 | Intrathecal B-Cell Clonal Expansion, an Early Sign of Humoral Immunity, in the Cerebrospinal Fluid of Patients with Clinically Isolated Syndrome Suggestive of Multiple Sclerosis | Laboratory Investigation | 2003 | 100 |
| 39 | Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer’s Disease | Frontiers in Neurology | 2015 | 97 |
| 40 | Fibril Formation and Neurotoxicity by a Herpes Simplex Virus Glycoprotein B Fragment with Homology to the Alzheimer's Aβ Peptide | Biochemistry | 2000 | 94 |
| 41 | A Novel, Noninvasive, Predictive Epilepsy Biomarker with Clinical Potential | Journal of Neuroscience | 2014 | 92 |
| 42 | Safety and efficacy of intravenous bimagrumab in inclusion body myositis (RESILIENT): a randomised, double-blind, placebo-controlled phase 2b trial | Lancet Neurology, The | 2019 | 91 |
| 43 | Cognition and Event-Related Potentials. | Annals of the New York Academy of Sciences | 1984 | 90 |
| 44 | Histological and Functional Benefit Following Transplantation of Motor Neuron Progenitors to the Injured Rat Spinal Cord | PLoS ONE | 2010 | 90 |
| 45 | An Early Event-Related Cortical Potential | Psychophysiology | 1978 | 87 |
| 46 | Cauda Equina Syndrome in Patients Undergoing Manipulation of the Lumbar Spine | Spine | 1992 | 84 |
| 47 | Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old | Brain | 2011 | 82 |
| 48 | Low-doses of cisplatin injure hippocampal synapses: A mechanism for ‘chemo’ brain? | Experimental Neurology | 2014 | 81 |
| 49 | Concepts for brain aging: resistance, resilience, reserve, and compensation | Alzheimer's Research and Therapy | 2019 | 81 |
| 50 | Selectivity of attenuation (i.e., gating) of somatosensory potentials during voluntary movement in humans | Electroencephalography and Clinical Neurophysiology - Evoked Potentials | 1987 | 79 |
