| # | Title | Journal | Year | Citations |
|---|
| 1 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study | Lancet Oncology, The | 2011 | 3,758 |
| 2 | ceRNA in cancer: possible functions and clinical implications | Journal of Medical Genetics | 2015 | 1,031 |
| 3 | Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer | Nature Communications | 2018 | 669 |
| 4 | TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment | Nucleic Acids Research | 2021 | 481 |
| 5 | Dual AO/EB Staining to Detect Apoptosis in Osteosarcoma Cells Compared with Flow Cytometry | Medical Science Monitor Basic Research | 2015 | 456 |
| 6 | Final overall survival results from a randomised, phase III study of erlotinib versus chemotherapy as first-line treatment of EGFR mutation-positive advanced non-small-cell lung cancer (OPTIMAL, CTONG-0802) | Annals of Oncology | 2015 | 406 |
| 7 | Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice | Nature Communications | 2019 | 404 |
| 8 | The role of ubiquitination in tumorigenesis and targeted drug discovery | Signal Transduction and Targeted Therapy | 2020 | 338 |
| 9 | Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli | Nature Microbiology | 2019 | 313 |
| 10 | BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis | Lancet Respiratory Medicine,the | 2016 | 307 |
| 11 | Predicting EGFR mutation status in lung adenocarcinoma on computed tomography image using deep learning | European Respiratory Journal | 2019 | 298 |
| 12 | Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer | Nature Communications | 2021 | 295 |
| 13 | Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial | Lancet Diabetes and Endocrinology,the | 2017 | 245 |
| 14 | Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells | Cell Death and Differentiation | 2013 | 242 |
| 15 | Overexpressed circPVT1, a potential new circular RNA biomarker, contributes to doxorubicin and cisplatin resistance of osteosarcoma cells by regulating ABCB1 | International Journal of Biological Sciences | 2018 | 223 |
| 16 | Short-term Exposure to Ambient Fine Particulate Matter Increases Hospitalizations and Mortality in COPD | Chest | 2016 | 222 |
| 17 | CSH guidelines for the diagnosis and treatment of drug-induced liver injury | Hepatology International | 2017 | 206 |
| 18 | Therapeutic effect of subcutaneous injection of low dose recombinant human granulocyte-macrophage colony-stimulating factor on pulmonary alveolar proteinosis | Respiratory Research | 2020 | 200 |
| 19 | Gefitinib or Erlotinib vs Chemotherapy for EGFR Mutation-Positive Lung Cancer: Individual Patient Data Meta-Analysis of Overall Survival | Journal of the National Cancer Institute | 2017 | 196 |
| 20 | Three-dimensional porous scaffold by self-assembly of reduced graphene oxide and nano-hydroxyapatite composites for bone tissue engineering | Carbon | 2017 | 191 |
| 21 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries | Cell Research | 2013 | 176 |
| 22 | Mesoporous Silica Nanoparticles Capped with Disulfide-Linked PEG Gatekeepers for Glutathione-Mediated Controlled Release | ACS Applied Materials & Interfaces | 2012 | 175 |
| 23 | Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a | Molecular Cancer | 2018 | 171 |
| 24 | Synthesis of reduced graphene oxide/magnetite composites and investigation of their adsorption performance of fluoroquinolone antibiotics | Colloids and Surfaces A: Physicochemical and Engineering Aspects | 2013 | 169 |
| 25 | 3D printed PCL/SrHA scaffold for enhanced bone regeneration | Chemical Engineering Journal | 2019 | 169 |
| 26 | A Deep Learning-Based Approach for Automated Yellow Rust Disease Detection from High-Resolution Hyperspectral UAV Images | Remote Sensing | 2019 | 168 |
| 27 | Stress recovery and restorative effects of viewing different urban park scenes in Shanghai, China | Urban Forestry and Urban Greening | 2016 | 160 |
| 28 | Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance | Molecular Therapy | 2019 | 157 |
| 29 | Dysbiosis Signatures of Gut Microbiota Along the Sequence from Healthy, Young Patients to Those with Overweight and Obesity | Obesity | 2018 | 155 |
| 30 | Computational approaches for microRNA studies: a review | Mammalian Genome | 2010 | 152 |
| 31 | 3D Deep Learning from CT Scans Predicts Tumor Invasiveness of Subcentimeter Pulmonary Adenocarcinomas | Cancer Research | 2018 | 150 |
| 32 | N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer | Molecular Cancer | 2021 | 150 |
| 33 | MiR-214 regulate gastric cancer cell proliferation, migration and invasion by targeting PTEN | Cancer Cell International | 2013 | 149 |
| 34 | The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis | BMC Cancer | 2013 | 146 |
| 35 | Wearable, ultrathin and transparent bacterial celluloses/MXene film with Janus structure and excellent mechanical property for electromagnetic interference shielding | Chemical Engineering Journal | 2021 | 145 |
| 36 | New insights into the evasion of host innate immunity by Mycobacterium tuberculosis | Cellular and Molecular Immunology | 2020 | 144 |
| 37 | Risk of bone fractures associated with glucagon-like peptide-1 receptor agonists’ treatment: a meta-analysis of randomized controlled trials | Endocrine | 2015 | 143 |
| 38 | Tenotomy or tenodesis for long head biceps lesions in shoulders with reparable rotator cuff tears: a prospective randomised trial | Knee Surgery, Sports Traumatology, Arthroscopy | 2015 | 143 |
| 39 | Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and Rejuvenation Strategies | Frontiers in Cell and Developmental Biology | 2020 | 142 |
| 40 | Consolidative Local Ablative Therapy Improves the Survival of Patients With Synchronous Oligometastatic NSCLC Harboring EGFR Activating Mutation Treated With First-Line EGFR-TKIs | Journal of Thoracic Oncology | 2018 | 140 |
| 41 | The therapeutic efficacy of CdTe and CdSe quantum dots for photothermal cancer therapy | Biomaterials | 2012 | 133 |
| 42 | All‐in‐One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed‐Release of Exosome and Fibroblast Growth Factor | Small | 2022 | 133 |
| 43 | Nanozymes-recent development and biomedical applications | Journal of Nanobiotechnology | 2022 | 133 |
| 44 | Tumor Spread through Air Spaces Affects the Recurrence and Overall Survival in Patients with Lung Adenocarcinoma >2 to 3 cm | Journal of Thoracic Oncology | 2017 | 132 |
| 45 | Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity | Cell Biology and Toxicology | 2020 | 131 |
| 46 | Self-healing, anti-freezing, adhesive and remoldable hydrogel sensor with ion-liquid metal dual conductivity for biomimetic skin | Composites Science and Technology | 2021 | 130 |
| 47 | Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy | Redox Biology | 2019 | 129 |
| 48 | Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1-mediated autophagy | American Journal of Physiology - Cell Physiology | 2020 | 126 |
| 49 | The circadian clock gene Bmal1 acts as a potential anti-oncogene in pancreatic cancer by activating the p53 tumor suppressor pathway | Cancer Letters | 2016 | 124 |
| 50 | Circular RNA circ_HIPK3 is down-regulated and suppresses cell proliferation, migration and invasion in osteosarcoma | Journal of Cancer | 2018 | 124 |
