| # | Title | Journal | Year | Citations |
|---|
| 1 | The aetiology and molecular landscape of insulin resistance | Nature Reviews Molecular Cell Biology | 2021 | 221 |
| 2 | Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis | Gut | 2022 | 195 |
| 3 | Image-based profiling for drug discovery: due for a machine-learning upgrade? | Nature Reviews Drug Discovery | 2021 | 194 |
| 4 | Enhanced liver fibrosis test for the non-invasive diagnosis of fibrosis in patients with NAFLD: A systematic review and meta-analysis | Journal of Hepatology | 2020 | 170 |
| 5 | Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis | Journal of Hepatology | 2021 | 149 |
| 6 | Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models | EBioMedicine | 2018 | 99 |
| 7 | ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials | Nature Medicine | 2021 | 97 |
| 8 | Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell–derived cortical interneurons from subjects with schizophrenia | Nature Neuroscience | 2019 | 84 |
| 9 | GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates | Cell Metabolism | 2020 | 70 |
| 10 | Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils | Blood | 2017 | 68 |
| 11 | Improving the generation and selection of virtual populations in quantitative systems pharmacology models | Progress in Biophysics and Molecular Biology | 2018 | 64 |
| 12 | Free Water in White Matter Differentiates MCI and AD From Control Subjects | Frontiers in Aging Neuroscience | 2019 | 57 |
| 13 | Accuracy of cytokeratin 18 (M30 and M65) in detecting non-alcoholic steatohepatitis and fibrosis: A systematic review and meta-analysis | PLoS ONE | 2020 | 40 |
| 14 | Activation of the hypothalamic–pituitary–adrenal axis by exogenous and endogenous GDF15 | Proceedings of the National Academy of Sciences of the United States of America | 2021 | 40 |
| 15 | Abnormal clotting of the intrinsic/contact pathway in Alzheimer disease patients is related to cognitive ability | Blood Advances | 2018 | 33 |
| 16 | Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension | ELife | 2020 | 33 |
| 17 | Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition | PLoS ONE | 2019 | 30 |
| 18 | FGF21 increases water intake, urine output and blood pressure in rats | PLoS ONE | 2018 | 26 |
| 19 | The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging | Journal of Medicinal Chemistry | 2017 | 24 |
| 20 | FibroTest for Evaluating Fibrosis in Non-Alcoholic Fatty Liver Disease Patients: A Systematic Review and Meta-Analysis | Journal of Clinical Medicine | 2021 | 24 |
| 21 | Systematic Review with Meta-Analyses: Diagnostic Accuracy of FibroMeter Tests in Patients with Non-Alcoholic Fatty Liver Disease | Journal of Clinical Medicine | 2021 | 23 |
| 22 | Systematic Review with Meta-Analysis: Diagnostic Accuracy of Pro-C3 for Hepatic Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease | Biomedicines | 2021 | 21 |
| 23 | Efficacy and safety of the glucagon receptor antagonist PF‐06291874: A 12‐week, randomized, dose‐response study in patients with type 2 diabetes mellitus on background metformin therapy | Diabetes, Obesity and Metabolism | 2018 | 20 |
| 24 | Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance | JHEP Reports | 2022 | 20 |
| 25 | The reverse translation of a quantitative neuropsychiatric framework into preclinical studies: Focus on social interaction and behavior | Neuroscience and Biobehavioral Reviews | 2019 | 19 |
| 26 | Addressing unmet needs for people with cancer cachexia: recommendations from a multistakeholder workshop | Journal of Cachexia, Sarcopenia and Muscle | 2022 | 19 |
| 27 | Multiple long-range inputs evoke NMDA currents in prefrontal cortex fast-spiking interneurons | Neuropsychopharmacology | 2018 | 16 |
| 28 | Hippocampal place cell dysfunction and the effects of muscarinic M1 receptor agonism in a rat model of Alzheimer's disease | Hippocampus | 2018 | 13 |
| 29 | Characterization of cachexia in the human fibrosarcoma HT‐1080 mouse tumour model | Journal of Cachexia, Sarcopenia and Muscle | 2020 | 13 |
| 30 | Predicting critical drug concentrations and torsadogenic risk using a multiscale exposure-response simulator | Progress in Biophysics and Molecular Biology | 2019 | 11 |
| 31 | Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation | Scientific Reports | 2021 | 11 |
| 32 | Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation | IScience | 2021 | 11 |
| 33 | A mathematical analysis of adaptations to the metabolic fate of fructose in essential fructosuria subjects | American Journal of Physiology - Endocrinology and Metabolism | 2018 | 10 |
| 34 | What Can Mathematics Do for Drug Development? | Bulletin of Mathematical Biology | 2019 | 9 |
| 35 | Perspectives on the Role of Mathematics in Drug Discovery and Development | Bulletin of Mathematical Biology | 2019 | 9 |
| 36 | Inhibition of Diacylglycerol Acyltransferase 2 Versus Diacylglycerol Acyltransferase 1: Potential Therapeutic Implications of Pharmacology | Clinical Therapeutics | 2023 | 9 |
| 37 | Development and validation of a quantitative ultra performance LC® hydrophilic interaction liquid chromatography MS/MS method to measure fructose and sorbitol in human plasma | Bioanalysis | 2019 | 7 |
| 38 | Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH | Journal of Visualized Experiments | 2021 | 7 |
| 39 | Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres | ACS Medicinal Chemistry Letters | 2019 | 6 |
| 40 | Changes in calpain-2 expression during glioblastoma progression predisposes tumor cells to temozolomide resistance by minimizing DNA damage and p53-dependent apoptosis | Cancer Cell International | 2023 | 6 |
| 41 | Analysis of compartments-in-series models of liver metabolism as partial differential equations: the effect of dispersion and number of compartments | Mathematical Biosciences and Engineering | 2019 | 5 |
| 42 | An assessment of thermoneutral housing conditions on murine cardiometabolic function | American Journal of Physiology - Heart and Circulatory Physiology | 2022 | 5 |
| 43 | AMPK activation is sufficient to increase skeletal muscle glucose uptake and glycogen synthesis but is not required for contraction-mediated increases in glucose metabolism | Heliyon | 2022 | 4 |
| 44 | Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors | Journal of Biological Chemistry | 2023 | 4 |
| 45 | A quantitative analysis of statistical power identifies obesity end points for improved in vivo preclinical study design | International Journal of Obesity | 2017 | 3 |
| 46 | Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH | Journal of Visualized Experiments | 2021 | 2 |
| 47 | Quantitative Systems Pharmacology: Modelling and simulating drug action in health and disease | Progress in Biophysics and Molecular Biology | 2018 | 1 |
| 48 | Structural basis of the acyl-transfer mechanism of human GPAT1 | Nature Structural and Molecular Biology | 2023 | 1 |
| 49 | The Role of Pool Size Measurements in Improving Flux Estimations in Non-Stationary Metabolic Flux Analysis | Biophysical Journal | 2019 | 0 |
| 50 | Combined Exercise Training and Sodium‐glucose Cotransporter 2 Inhibition Improves Glycemic Control and Exercise Tolerance When Compared to Pharmacotherapy Alone in a Model of Type 2 Diabetes | FASEB Journal | 2018 | 0 |
