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Top Articles

#TitleJournalYearCitations
1Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6Cell20061,399
2Toward a unified nomenclature for mammalian ADP-ribosyltransferasesTrends in Biochemical Sciences2010724
3Eukaryotic DNA PolymerasesAnnual Review of Biochemistry2002625
4Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?Microbiology and Molecular Biology Reviews2006593
5Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)Nature Communications2015463
6The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-κB in inflammatory disordersCellular and Molecular Life Sciences2002388
7A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activationNature Structural and Molecular Biology2009382
8γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomesDNA Repair2006371
9SIRT2 regulates NF-κB-dependent gene expression through deacetylation of p65 Lys310Journal of Cell Science2010319
10Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress ResponsesMolecular Cell2013315
11Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to FeedingCell2010309
12Substrate-Assisted Catalysis by PARP10 Limits Its Activity to Mono-ADP-RibosylationMolecular Cell2008299
13Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sitesNucleic Acids Research2009295
14The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressorsNature Communications2015281
15Acetylation of Poly(ADP-ribose) Polymerase-1 by p300/CREB-binding Protein Regulates Coactivation of NF-κB-dependent TranscriptionJournal of Biological Chemistry2005279
16Macrodomain-containing proteins are new mono-ADP-ribosylhydrolasesNature Structural and Molecular Biology2013276
17The Enzymatic and DNA Binding Activity of PARP-1 Are Not Required for NF-κB Coactivator FunctionJournal of Biological Chemistry2001275
18Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanineDNA Repair2010272
19SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1Molecular and Cellular Biology2009269
20Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cellsProceedings of the National Academy of Sciences of the United States of America2011262
21The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaksNature Cell Biology2011229
22PARP1 ADP-ribosylates lysine residues of the core histone tailsNucleic Acids Research2010226
23PARP-1 and gene regulation: Progress and puzzlesMolecular Aspects of Medicine2013217
24A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial FunctionCell Metabolism2014214
25Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal MuscleCell Metabolism2014211
26Transcriptional Coactivation of Nuclear Factor-κB-dependent Gene Expression by p300 Is Regulated by Poly(ADP)-ribose Polymerase-1Journal of Biological Chemistry2003208
27Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatinJournal of Cell Biology2008206
28Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and EpigeneticsAnnual Review of Biochemistry2015200
29Readers of poly(ADP-ribose): designed to be fit for purposeNucleic Acids Research2016198
30Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-κB-dependent gene expressionEMBO Journal2005195
31The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeatsEMBO Journal2010170
32HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelinationNature Neuroscience2011165
33Arginine Methylation Regulates DNA Polymerase βMolecular Cell2006161
34Histone ADP-ribosylation in DNA repair, replication and transcriptionTrends in Cell Biology2011161
35A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cellsNature Communications2016149
36BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrenceNature Genetics2015141
37Inheritance of Silent rDNA Chromatin Is Mediated by PARP1 via Noncoding RNAMolecular Cell2012136
38Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive reviewMolecular Cancer2015135
39Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhance the Expression of a Subset of NF-κB Target GenesMolecular Cell2012128
40The NBS1–Treacle complex controls ribosomal RNA transcription in response to DNA damageNature Cell Biology2014127
41lncRNA Maturation to Initiate Heterochromatin Formation in the Nucleolus Is Required for Exit from Pluripotency in ESCsCell Stem Cell2014124
42An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase  Proceedings of the National Academy of Sciences of the United States of America2009115
43Acetylation Regulates the DNA End-Trimming Activity of DNA Polymerase βMolecular Cell2002110
44Enhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic fieldNucleic Acids Research2006106
45Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1Nucleic Acids Research2001102
46Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulationOncogene200399
47PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phaseOncogene200398
48Characterization of PEI-coated superparamagnetic iron oxide nanoparticles for transfection: Size distribution, colloidal properties and DNA interactionJournal of Magnetism and Magnetic Materials200790
49Protein Arginine Methyltransferase 1 Coactivates NF-κB-Dependent Gene Expression Synergistically with CARM1 and PARP1Journal of Molecular Biology200887
50Antagonistic Cross-Regulation between Sox9 and Sox10 Controls an Anti-tumorigenic Program in MelanomaPLoS Genetics201585