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Department of Biochemistry and Molecular Biology
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top-articles
Department of Biochemistry and Molecular Biology
210
(top 1%)
papers
7.2K
(top 1%)
citations
47
(top 1%)
h
-index
77
(top 1%)
g
-index
212
all documents
7.4K
doc citations
1.6K
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
cAMP Analog Mapping of Epac1 and cAMP Kinase
Journal of Biological Chemistry
2003
367
2
Recessively inherited L-DOPA-responsive dystonia caused by a point mutation (Q381K) in the tyrosine hydroxylase gene
Human Molecular Genetics
1995
216
3
Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain
Neuron
1994
215
4
Tyrosine hydroxylase and Parkinson's disease
Molecular Neurobiology
1998
211
5
Significance of testing platelet functions
in vitro
European Journal of Clinical Investigation
1994
180
6
Expression of recombinant human phenylalanine hydroxylase as fusion protein in
Escherichia coli
circumvents proteolytic degradation by host cell proteases. Isolation and characterization of the wild-type enzyme
Biochemical Journal
1995
180
7
Recessively inherited L-DOPA-responsive parkinsonism in infancy caused by a point mutation (L205P) in the tyrosine hydroxylase gene
Human Molecular Genetics
1996
175
8
Identification of tryptophan hydroxylase as an intestinal autoantigen
Lancet, The
1998
168
9
Structural Insight into the Aromatic Amino Acid Hydroxylases and Their Disease-Related Mutant Forms
Chemical Reviews
1999
167
10
Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2
FEBS Journal
1993
164
11
Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria
Nature Structural Biology
1997
162
12
Neurokinin-3 receptor distribution in rat and human brain: an immunohistochemical study
Neuroscience
1999
132
13
Catecholamine biosynthesis and physiological regulation in neuroendocrine cells
Acta Physiologica Scandinavica
2000
120
14
Crystal Structure of the Ternary Complex of the Catalytic Domain of Human Phenylalanine Hydroxylase with Tetrahydrobiopterin and 3-(2-Thienyl)-l-alanine, and its Implications for the Mechanism of Catalysis and Substrate Activation
Journal of Molecular Biology
2002
115
15
Fine Mapping of 28S rRNA Sites Specifically Cleaved in Cells Undergoing Apoptosis
Molecular and Cellular Biology
1995
112
16
Localization of the small GTP-binding protein rab1p to early compartments of the secretory pathway
Journal of Cell Science
1995
107
17
High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin
Journal of Molecular Biology
2001
104
18
Retrograde Transport from the Pre-Golgi Intermediate Compartment and the Golgi Complex Is Affected by the Vacuolar H
+
-ATPase Inhibitor Bafilomycin A1
Molecular Biology of the Cell
1998
101
19
l
-Phenylalanine Binding and Domain Organization in Human Phenylalanine Hydroxylase: A Differential Scanning Calorimetry Study
Biochemistry
2002
99
20
Molecular Cloning and Expression of a 58-kDa cis-Golgi and Intermediate Compartment Protein
Journal of Biological Chemistry
1996
96
21
Regulation of tyrosine hydroxylase by stress-activated protein kinases
Journal of Neurochemistry
2002
94
22
Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line
Journal of Cellular Physiology
1994
93
23
Expression of the zebrafish gene
hlx-1
in the prechordal plate and during CNS development
Development (Cambridge)
1994
90
24
Structure/Function Relationships in Human Phenylalanine Hydroxylase. Effect of Terminal Deletions on the Oligomerization, Activation and Cooperativity of Substrate Binding to the Enzyme
FEBS Journal
1996
84
25
Identification of Tyrosine Hydroxylase as an Autoantigen in Autoimmune Polyendocrine Syndrome Type I
Biochemical and Biophysical Research Communications
2000
80
26
Conformational Properties and Stability of Tyrosine Hydroxylase Studied by Infrared Spectroscopy
Journal of Biological Chemistry
1996
79
27
Stimulation of extracellular matrix components in the normal brain by invading glioma cells
International Journal of Cancer
1998
78
28
The Membrane-bound Conformation of α-Lactalbumin Studied by NMR-monitored 1H Exchange
Journal of Molecular Biology
2002
71
29
Demonstration of a TGF-α-EGF-receptor autocrine loop and c-myc protein over-expression in papillary thyroid carcinomas
International Journal of Cancer
1993
69
30
Generation of Reactive Oxygen Species by Tyrosine Hydroxylase: A Possible Contribution to the Degeneration of Dopaminergic Neurons?
Journal of Neurochemistry
1997
69
31
Partial characterization and three-dimensional-structural localization of eight mutations in exon 7 of the human phenylalanine hydroxylase gene associated with phenylketonuria
FEBS Journal
1998
62
32
Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association
Journal of Neurochemistry
2001
62
33
The structural basis of the recognition of phenylalanine and pterin cofactors by phenylalanine hydroxylase: implications for the catalytic mechanism 1 1Edited by D. C. Rees
Journal of Molecular Biology
1999
61
34
Chorpromazine-induced increase in dipalmitoylphosphatidylserine surface area in monolayers at room temperature
Biochemical Pharmacology
2001
61
35
Conformation of the Substrate and Pterin Cofactor Bound to Human Tryptophan Hydroxylase. Important Role of Phe313 in Substrate Specificity
Biochemistry
2001
60
36
Phosphorylation of recombinant human phenylalanine hydroxylase: effect on catalytic activity, substrate activation and protection against non-specific cleavage of the fusion protein by restriction protease
Biochemical Journal
1996
59
37
The Interaction of Peripheral Proteins and Membranes Studied with α-Lactalbumin and Phospholipid Bilayers of Various Compositions
Journal of Biological Chemistry
2003
59
38
The compartmentalization of protein synthesis: Importance of cytoskeleton and role in mRNA targeting
International Journal of Biochemistry and Cell Biology
1996
58
39
Endoplasmic Reticulum to Golgi Trafficking in Multinucleated Skeletal Muscle Fibers
Experimental Cell Research
1997
58
40
Expression of c-erbB-3 and c-erbB-4 proteins in papillary thyroid carcinomas
Cancer Research
1996
56
41
Pancreatic Carboxylester Lipase from Atlantic Salmon (Salmo salar). cDNA Sequence and Computer-Assisted Modelling of Tertiary Structure
FEBS Journal
1994
53
42
Participation of a Stress-Activated Protein Kinase Cascade in the Activation of Tyrosine Hydroxylase in Chromaffin Cells
FEBS Journal
1997
53
43
Annexin II is associated with mRNAs which may constitute a distinct subpopulation
Biochemical Journal
2000
53
44
PKU mutation G46S is associated with increased aggregation and degradation of the phenylalanine hydroxylase enzyme
Human Mutation
1996
51
45
Drug-induced parkinsonism: cinnarizine and flunarizine are potent uncouplers of the vacuolar H+-ATPase in catecholamine storage vesicles
Neuropharmacology
1999
50
46
Ubiquitination of soluble and membrane-bound tyrosine hydroxylase and degradation of the soluble form
FEBS Journal
2002
50
47
Microheterogeneity of recombinant human phenylalanine hydroxylase as a result of nonenzymatic deamidations of labile amide containing amino acids
FEBS Journal
2000
48
48
Localization of the small GTP-binding protein rab1p to early compartments of the secretory pathway
Journal of Cell Science
1995
48
49
Dopamine Oxidation Generates an Oxidative Stress Mediated by Dopamine Semiquinone and Unrelated to Reactive Oxygen Species
Journal of Molecular and Cellular Cardiology
1997
46
50
Acyl-CoA Esters Antagonize the Effects of Ligands on Peroxisome Proliferator-activated Receptor α Conformation, DNA Binding, and Interaction with Co-factors
Journal of Biological Chemistry
2001
46
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