| # | Title | Journal | Year | Citations |
|---|
| 1 | Randomised placebo-controlled trial of ritonavir in advanced HIV-1 disease | Lancet, The | 1998 | 508 |
| 2 | 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease | Gastroenterology | 2002 | 485 |
| 3 | Minimum important difference between patients with rheumatoid arthritis: the patient's perspective | Journal of Rheumatology | 1993 | 348 |
| 4 | How Accurate Is Spirometry at Predicting Restrictive Pulmonary Impairment? | Chest | 1999 | 206 |
| 5 | CONTROLLED TRIAL OF NIFEDIPINE IN THE TREATMENT OF RAYNAUD'S PHENOMENON | Lancet, The | 1982 | 160 |
| 6 | Methotrexate pneumonitis in rheumatoid arthritis: potential risk factors. Four case reports and a review of the literature | Journal of Rheumatology | 1987 | 152 |
| 7 | The Role of Ipratropium Bromide in the Emergency Management of Acute Asthma Exacerbation: A Metaanalysis of Randomized Clinical Trials | Annals of Emergency Medicine | 1999 | 133 |
| 8 | Normal hearing thresholds for clicks | Journal of the Acoustical Society of America | 1982 | 130 |
| 9 | Neurocysticercosis: Neglected but Not Forgotten | PLoS Neglected Tropical Diseases | 2012 | 128 |
| 10 | An Open-Label Pilot Study Using Thioguanine as a Therapeutic Alternative in Crohn's Disease Patients Resistant to 6-Mercaptopurine Therapy | Inflammatory Bowel Diseases | 2001 | 127 |
| 11 | Detection of HIV Type 1envSubtypes A, B, C, and E in Asia Using Dried Blood Spots: A New Surveillance Tool for Molecular Epidemiology | AIDS Research and Human Retroviruses | 1996 | 113 |
| 12 | Low-dose methotrexate compared with azathioprine in the treatment of rheumatoid arthritis. a twenty-four—week controlled clinical trial | Arthritis and Rheumatism | 1987 | 99 |
| 13 | Dynamic correlation of apoptosis and immune activation during treatment of HIV infection | Cell Death and Differentiation | 1999 | 94 |
| 14 | The History of Lupus Erythematosus | Rheumatic Disease Clinics of North America | 1988 | 86 |
| 15 | Boerhaave revisited: Spontaneous esophageal perforation as a diagnostic masquerader | American Journal of Medicine | 1989 | 83 |
| 16 | Induction of zidovudine glucuronidation and amination pathways by rifampicin in HIV-infected patients | British Journal of Clinical Pharmacology | 1999 | 83 |
| 17 | Adverse effects of low dose methotrexate therapy in rheumatoid arthritis | Journal of Rheumatology | 1993 | 76 |
| 18 | Isolation of a cell-detaching factor of Trichomonas vaginalis | Journal of Clinical Microbiology | 1989 | 65 |
| 19 | Comparative studies of the major histocompatibility complex in french canadian and non–french canadian caucasians with systemic lupus erythematosus | Arthritis and Rheumatism | 1993 | 55 |
| 20 | Primary thrombocythemia in pregnancy: A report of two cases | American Journal of Obstetrics and Gynecology | 1988 | 51 |
| 21 | Raised ESR in polymyalgia rheumatica no longer a sine qua non? | Lancet, The | 1996 | 50 |
| 22 | Management of steroid-dependent asthma with methotrexate: a meta-analysis of randomized clinical trials | Respiratory Medicine | 1998 | 49 |
| 23 | Downregulation of Neuronal Nitric Oxide Synthase in the Rat Remnant Kidney | Journal of the American Society of Nephrology: JASN | 1999 | 46 |
| 24 | Thrombotic thrombocytopenic purpura following hemorrhagic colitis due to Escherichia coli 0157:H7 | American Journal of Medicine | 1990 | 45 |
| 25 | Lamellar bone turnover system and its effector organ | Calcified Tissue International | 1984 | 43 |
| 26 | Structural disorders at the insertion of the supraspinatus tendon. Relation to tensile strength | Journal of Bone and Joint Surgery: British Volume | 1998 | 43 |
| 27 | Therapeutic value of colchicine in the treatment of patients with psoriatic arthritis. | Annals of the Rheumatic Diseases | 1993 | 42 |
| 28 | MHC studies of the primary antiphospholipid antibody syndrome and of antiphospholipid antibodies in systemic lupus erythematosus | Journal of Rheumatology | 1996 | 39 |
| 29 | The presence of delayed hypersensitivity reactions in patients toward cellular extracts of their malignant tumors.3. The frequency, duration, and cross reactivity of this phenomenon in patients with breast cancer, and its correlation with survival | Cancer | 1971 | 36 |
| 30 | Quantitative histological measurements of bone turnover in primary hyperparathyroidism | Calcified Tissue Research | 1973 | 36 |
| 31 | Gold sodium thiomalate compared to low dose methotrexate in the treatment of rheumatoid arthritis--a randomized, double blind 26-week trial | Journal of Rheumatology | 1989 | 36 |
| 32 | Clobazam in Long-Term Epilepsy Treatment: Sustained Responders Versus Those Developing Tolerance | Epilepsia | 1995 | 34 |
| 33 | The influence of chronic administration of calcium carbonate on the bioavailability of oral ciprofloxacin | British Journal of Clinical Pharmacology | 1993 | 34 |
| 34 | In vitro Cellular Immunity and in vivo Delayed Hypersensitivity in Uremic Patients Maintained on Hemodialysis | International Archives of Allergy and Immunology | 1974 | 33 |
| 35 | Immunological enhancement of breast cancer | Parasitology | 1997 | 33 |
| 36 | The possible role of stromal cell stimulation in worsening the prognosis of a subset of patients with breast cancer | Clinical and Experimental Metastasis | 1993 | 32 |
| 37 | Risk factors for acquiring ampicillin-resistant enterococci and clinical outcomes at a Canadian tertiary-care hospital | Journal of Clinical Microbiology | 1994 | 31 |
| 38 | THE USE OF CYCLOSPORIN A IN RHEUMATOID ARTHRITIS: CONCLUSIONS OF AN INTERNATIONAL REVIEW | Rheumatology | 1994 | 28 |
| 39 | The use of ozone-treated blood in the therapy of HIV infection and immune disease | Aids | 1991 | 27 |
| 40 | The effect of a protein meal on zidovudine pharmacokinetics in HIV‐ infected patients. | British Journal of Clinical Pharmacology | 1992 | 27 |
| 41 | Giant cell arteritis (temporal arteritis) affecting the breast: report of two cases and review of published reports. | Annals of the Rheumatic Diseases | 1990 | 26 |
| 42 | Canadian survey of antimicrobial resistance in Klebsiella spp. and Enterobacter spp | Journal of Antimicrobial Chemotherapy | 1993 | 26 |
| 43 | Analysis of the extracellular proteases ofTrichomonas vaginalis | Parasitology Research | 1994 | 26 |
| 44 | National Survey of Radionuclide Gastric Emptying Studies | Canadian Journal of Gastroenterology & Hepatology | 1997 | 24 |
| 45 | A Muscle-Specific Enhancer Within Intron 1 of the Human Dystrophin Gene is Functionally Dependent on Single MEF-1/E Box and MEF-2/AT-Rich Sequence Motifs | Nucleic Acids Research | 1997 | 23 |
| 46 | Characterization of reticulofibroblastoid colonies (CFU-RF) derived from bone marrow and long-term marrow culture monolayers | Journal of Cellular Physiology | 1986 | 22 |
| 47 | Clinical correlates, serum autoantibodies and the role of the major histocompatibility complex in French Canadian and non-French Canadian Caucasians with SLE | Lupus | 1998 | 22 |
| 48 | Inducible immunity with a pilus preparation booster vaccination in an animal model of Haemophilus ducreyi infection and disease | Infection and Immunity | 1995 | 22 |
| 49 | Assessing adaptive and maladaptive coping in the early phase of acute myocardial infarction | Journal of Behavioral Medicine | 1991 | 21 |
| 50 | Effect of Multivitamins on Plasma Homocysteine and Folate Levels in Patients on Hemodialysis | ASAIO Journal | 1999 | 21 |
