| # | Title | Journal | Year | Citations |
|---|
| 1 | Frequent pathway mutations of splicing machinery in myelodysplasia | Nature | 2011 | 1,764 |
| 2 | Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 1,749 |
| 3 | Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial | Lancet Oncology, The | 2014 | 849 |
| 4 | Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib | JAMA Oncology | 2020 | 746 |
| 5 | A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells | Blood | 2008 | 431 |
| 6 | Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms | Nature | 2009 | 380 |
| 7 | Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms | Nature Genetics | 2013 | 334 |
| 8 | Tenofovir disoproxil fumarate (TDF), emtricitabine/TDF, and entecavir in patients with decompensated chronic hepatitis B liver disease | Hepatology | 2011 | 274 |
| 9 | Angiographic Morphologic Features of Infarct-Related Arteries and Timely Reperfusion in Acute Myocardial Infarction | Chest | 2002 | 271 |
| 10 | Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: a comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse | Blood | 2002 | 268 |
| 11 | Nivolumab plus chemotherapy versus placebo plus chemotherapy in patients with HER2-negative, untreated, unresectable advanced or recurrent gastric or gastro-oesophageal junction cancer (ATTRACTION-4): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial | Lancet Oncology, The | 2022 | 268 |
| 12 | Liver Biochemical Tests and Dengue Fever | American Journal of Tropical Medicine and Hygiene | 1992 | 256 |
| 13 | Intraductal papillary neoplasia of the liver associated with hepatolithiasis | Hepatology | 2001 | 252 |
| 14 | Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool | Science Translational Medicine | 2013 | 233 |
| 15 | Somatic SETBP1 mutations in myeloid malignancies | Nature Genetics | 2013 | 229 |
| 16 | Pan-Asian adapted Clinical Practice Guidelines for the management of patients with metastatic non-small-cell lung cancer: a CSCO–ESMO initiative endorsed by JSMO, KSMO, MOS, SSO and TOS | Annals of Oncology | 2019 | 214 |
| 17 | An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia | Cancer Cell | 2012 | 213 |
| 18 | Incidence and prevalence rates of diabetes mellitus in Taiwan: Analysis of the 2000–2009 Nationwide Health Insurance database | Journal of the Formosan Medical Association | 2012 | 205 |
| 19 | Triglyceride Glucose-Body Mass Index Is a Simple and Clinically Useful Surrogate Marker for Insulin Resistance in Nondiabetic Individuals | PLoS ONE | 2016 | 197 |
| 20 | Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells | Oncogene | 2008 | 195 |
| 21 | Fracture liaison services improve outcomes of patients with osteoporosis-related fractures: A systematic literature review and meta-analysis | Bone | 2018 | 189 |
| 22 | High-purity and label-free isolation of circulating tumor cells (CTCs) in a microfluidic platform by using optically-induced-dielectrophoretic (ODEP) force | Lab on A Chip | 2013 | 187 |
| 23 | Aerobic interval training improves oxygen uptake efficiency by enhancing cerebral and muscular hemodynamics in patients with heart failure | International Journal of Cardiology | 2013 | 184 |
| 24 | Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse | Blood | 2015 | 180 |
| 25 | Correlation between ultrasonographic and pathologic diagnoses of hepatitis B and C virus-related cirrhosis | Journal of Gastroenterology | 2003 | 179 |
| 26 | Association of Psoriasis With Inflammatory Bowel Disease | JAMA Dermatology | 2018 | 174 |
| 27 | Clinical characteristics and prognostic factors of splenic abscess: A review of 67 cases in a single medical center of Taiwan | World Journal of Gastroenterology | 2006 | 169 |
| 28 | BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders | Blood | 2013 | 169 |
| 29 | Adriamycin-induced Cardiomyocyte and Endothelial Cell Apoptosis: In Vitro and In Vivo Studies | Journal of Molecular and Cellular Cardiology | 2002 | 165 |
| 30 | Hand-foot skin reaction in patients treated with sorafenib: a clinicopathological study of cutaneous manifestations due to multitargeted kinase inhibitor therapy | British Journal of Dermatology | 2008 | 165 |
| 31 | Thyroid Cancer in the Thyroid Nodules Evaluated by Ultrasonography and Fine-Needle Aspiration Cytology | Thyroid | 2005 | 160 |
| 32 | A phase 3 study of nivolumab in previously treated advanced gastric or gastroesophageal junction cancer (ATTRACTION-2): 2-year update data | Gastric Cancer | 2020 | 155 |
| 33 | Localised plasmacytomas in Taiwan: comparison between extramedullary plasmacytoma and solitary plasmacytoma of bone | British Journal of Cancer | 1995 | 154 |
| 34 | RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation | Leukemia | 2009 | 143 |
| 35 | Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia | Leukemia | 2004 | 141 |
| 36 | A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients | British Journal of Cancer | 2010 | 138 |
| 37 | Phase II study of gemcitabine in patients with advanced hepatocellular carcinoma | Cancer | 2000 | 135 |
| 38 | Prospective Study of Warfarin Dosage Requirements Based on CYP2C9 and VKORC1 Genotypes | Clinical Pharmacology and Therapeutics | 2008 | 135 |
| 39 | Endotoxemia contributes to the immune paralysis in patients with cirrhosis | Journal of Hepatology | 2007 | 132 |
| 40 | Hepatic androgen receptor suppresses hepatocellular carcinoma metastasis through modulation of cell migration and anoikis | Hepatology | 2012 | 130 |
| 41 | A KRAS mutation status-stratified randomized phase II trial of gemcitabine and oxaliplatin alone or in combination with cetuximab in advanced biliary tract cancer | Annals of Oncology | 2015 | 130 |
| 42 | Refractures in cemented vertebrae after percutaneous vertebroplasty: a retrospective analysis | European Spine Journal | 2008 | 128 |
| 43 | Oral inoculation of probioticsLactobacillus acidophilusNCFM suppresses tumour growth both in segmental orthotopic colon cancer and extra-intestinal tissue | British Journal of Nutrition | 2012 | 128 |
| 44 | Plantar fasciitis treated with local steroid injection: comparison between sonographic and palpation guidance | Journal of Clinical Ultrasound | 2006 | 121 |
| 45 | Lactococcus garvieae infections in humans: possible association with aquaculture outbreaks | International Journal of Clinical Practice | 2006 | 120 |
| 46 | Factors Related to the Survival of Papillary and Follicular Thyroid Carcinoma Patients with Distant Metastases | Thyroid | 1999 | 119 |
| 47 | Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement | Leukemia | 2006 | 119 |
| 48 | Hyperoxia increases ventilator-induced lung injury via mitogen-activated protein kinases: a prospective, controlled animal experiment | Critical Care | 2007 | 117 |
| 49 | Cabozantinib in hepatocellular carcinoma: results of a phase 2 placebo-controlled randomized discontinuation study | Annals of Oncology | 2017 | 116 |
| 50 | Clinical and Pathological Characteristics of Secondary Thyroid Cancer | Thyroid | 1998 | 114 |
