| # | Title | Journal | Year | Citations |
|---|
| 1 | The McGill Pain Questionnaire: Major properties and scoring methods | Pain | 1975 | 5,648 |
| 2 | Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat | Science | 1999 | 1,741 |
| 3 | Cortisol levels during human aging predict hippocampal atrophy and memory deficits | Nature Neuroscience | 1998 | 1,425 |
| 4 | Suicide and suicidal behaviour | Lancet, The | 2016 | 1,291 |
| 5 | Apolipoprotein E polymorphism and Alzheimer's disease | Lancet, The | 1993 | 1,216 |
| 6 | Genome-wide association study identifies 30 loci associated with bipolar disorder | Nature Genetics | 2019 | 1,191 |
| 7 | Epidemiological surveys of autism and other pervasive developmental disorders: an update | Journal of Autism and Developmental Disorders | 2003 | 1,176 |
| 8 | Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism | Neuron | 2011 | 1,146 |
| 9 | Risk Factors for Depression Among Elderly Community Subjects: A Systematic Review and Meta-Analysis | American Journal of Psychiatry | 2003 | 1,092 |
| 10 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 11 | Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder | Bipolar Disorders | 2018 | 1,079 |
| 12 | Current advances and trends in the treatment of depression | Trends in Pharmacological Sciences | 1994 | 1,040 |
| 13 | Effect of neonatal handling on age-related impairments associated with the hippocampus | Science | 1988 | 1,027 |
| 14 | Regulation of firing of dopaminergic neurons and control of goal-directed behaviors | Trends in Neurosciences | 2007 | 883 |
| 15 | The Value and Challenges of Participatory Research: Strengthening Its Practice | Annual Review of Public Health | 2008 | 823 |
| 16 | Physical Aggression During Early Childhood: Trajectories and Predictors | Pediatrics | 2004 | 817 |
| 17 | Early Environmental Regulation of Forebrain Glucocorticoid Receptor Gene Expression: Implications for Adrenocortical Responses to Stress; pp. 49–60 | Developmental Neuroscience | 1996 | 804 |
| 18 | Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder | Canadian Journal of Psychiatry | 2016 | 746 |
| 19 | Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013 | Bipolar Disorders | 2013 | 740 |
| 20 | Assessment of the cortisol awakening response: Expert consensus guidelines | Psychoneuroendocrinology | 2016 | 727 |
| 21 | Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder | Nature Neuroscience | 2017 | 691 |
| 22 | Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy | Neuroscience and Biobehavioral Reviews | 2020 | 681 |
| 23 | Tryptophan depletion causes a rapid lowering of mood in normal males | Psychopharmacology | 1985 | 678 |
| 24 | Five-Year Risk of Cardiac Mortality in Relation to Initial Severity and One-Year Changes in Depression Symptoms After Myocardial Infarction | Circulation | 2002 | 651 |
| 25 | Psychiatric Status of Hyperactives as Adults: A Controlled Prospective 15-Year Follow-up of 63 Hyperactive Children | Journal of the American Academy of Child Psychiatry | 1985 | 632 |
| 26 | Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology | Nature Genetics | 2021 | 629 |
| 27 | Variations in the Hypothalamic-Pituitary-Adrenal Response to Stress during the Estrous Cycle in the Rat | Endocrinology | 1991 | 624 |
| 28 | Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 615 |
| 29 | Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 608 |
| 30 | Neural correlates of the LSD experience revealed by multimodal neuroimaging | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 586 |
| 31 | Effects of the Social Environment and Stress on Glucocorticoid Receptor Gene Methylation: A Systematic Review | Biological Psychiatry | 2016 | 582 |
| 32 | Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders | BMC Psychiatry | 2014 | 569 |
| 33 | Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity | Journal of Neuroscience | 2002 | 563 |
| 34 | Sex-specific transcriptional signatures in human depression | Nature Medicine | 2017 | 532 |
| 35 | Effects of prenatal infection on brain development and behavior: A review of findings from animal models | Brain, Behavior, and Immunity | 2010 | 521 |
| 36 | Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood | JAMA Psychiatry | 2019 | 519 |
| 37 | Brain charts for the human lifespan | Nature | 2022 | 518 |
| 38 | Deactivation of the Limbic System During Acute Psychosocial Stress: Evidence from Positron Emission Tomography and Functional Magnetic Resonance Imaging Studies | Biological Psychiatry | 2008 | 516 |
| 39 | The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making | Brain Structure and Function | 2010 | 506 |
| 40 | The Effects of Early Rearing Environment on the Development of GABAA and Central Benzodiazepine Receptor Levels and Novelty-Induced Fearfulness in the Rat | Neuropsychopharmacology | 2000 | 499 |
| 41 | Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation | Science | 2016 | 490 |
| 42 | The sexual desire inventory: Development, factor structure, and evidence of reliability | Journal of Sex and Marital Therapy | 1996 | 482 |
| 43 | Alcohol promotes dopamine release in the human nucleus accumbens | Synapse | 2003 | 482 |
| 44 | Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats | Journal of Neuroscience | 1995 | 474 |
| 45 | Prenatal stress and brain development | Brain Research Reviews | 2010 | 467 |
| 46 | The Bank of Standardized Stimuli (BOSS), a New Set of 480 Normative Photos of Objects to Be Used as Visual Stimuli in Cognitive Research | PLoS ONE | 2010 | 466 |
| 47 | Randomised trial of home-based psychosocial nursing intervention for patients recovering from myocardial infarction | Lancet, The | 1997 | 461 |
| 48 | The social environment and the epigenome | Environmental and Molecular Mutagenesis | 2008 | 454 |
| 49 | Stress hormones and human memory function across the lifespan | Psychoneuroendocrinology | 2005 | 452 |
| 50 | Stress, memory, and the hippocampus: can't live with it, can't live without it | Behavioural Brain Research | 2001 | 450 |
