| # | Title | Journal | Year | Citations |
|---|
| 1 | CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer | Nature Genetics | 2006 | 1,715 |
| 2 | Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension | New England Journal of Medicine | 1993 | 1,698 |
| 3 | Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial | Lancet Oncology, The | 2005 | 1,400 |
| 4 | Classification of colorectal cancer based on correlation of clinical, morphological and molecular features | Histopathology | 2007 | 1,200 |
| 5 | PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest | Nature Medicine | 2002 | 880 |
| 6 | Subgroup-specific structural variation across 1,000 medulloblastoma genomes | Nature | 2012 | 761 |
| 7 | Anomalous Origin of the Left Coronary Artery from the Pulmonary Trunk | Circulation | 1968 | 574 |
| 8 | Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition | Human Molecular Genetics | 2001 | 539 |
| 9 | High Prevalence of Sessile Serrated Adenomas With BRAF Mutations: A Prospective Study of Patients Undergoing Colonoscopy | Gastroenterology | 2006 | 512 |
| 10 | Cutaneous melanoma | Lancet, The | 2014 | 465 |
| 11 | TNM residual tumor classification revisited | Cancer | 2002 | 423 |
| 12 | Application of the Cavalieri principle and vertical sections method to lung: estimation of volume and pleural surface area | Journal of Microscopy | 1988 | 397 |
| 13 | Comparison of polarization properties of human adult microglia and blood‐derived macrophages | Glia | 2012 | 393 |
| 14 | Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type | Nature Genetics | 2014 | 383 |
| 15 | High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints | International Journal of Molecular Sciences | 2019 | 381 |
| 16 | Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18 | Vaccine | 2006 | 380 |
| 17 | CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer | Breast Cancer Research | 2012 | 376 |
| 18 | Impaired Bone Marrow Microenvironment and Immune Function in T Cell Protein Tyrosine Phosphatase–deficient Mice | Journal of Experimental Medicine | 1997 | 339 |
| 19 | Colorectal Carcinoma: Diagnostic, Prognostic, and Molecular Features | Modern Pathology | 2003 | 323 |
| 20 | Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16–26 years: a randomised, double-blind trial | Lancet, The | 2017 | 314 |
| 21 | The developmental biology of annual fishes. III. Pre-embryonic and embryonic diapause of variable duration in the eggs of annual fishes | The Journal of Experimental Zoology | 1972 | 298 |
| 22 | Upper Airway Muscle Inflammation and Denervation Changes in Obstructive Sleep Apnea | American Journal of Respiratory and Critical Care Medicine | 2004 | 292 |
| 23 | Pathology and physiopathology of adenomyosis | Best Practice and Research in Clinical Obstetrics and Gynaecology | 2006 | 283 |
| 24 | Trained immunity, tolerance, priming and differentiation: distinct immunological processes | Nature Immunology | 2021 | 274 |
| 25 | Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis | Lancet, The | 1993 | 270 |
| 26 | Angiogenesis and growth factor expression in a model of transmyocardial revascularization | Annals of Thoracic Surgery | 1998 | 270 |
| 27 | The CpG Island Methylator Phenotype and Chromosomal Instability Are Inversely Correlated in Sporadic Colorectal Cancer | Gastroenterology | 2007 | 264 |
| 28 | A combined analysis of outcome following breast cancer: differences in survival based on BRCA1/BRCA2 mutation status and administration of adjuvant treatment | Breast Cancer Research | 2003 | 262 |
| 29 | The Inhibitory Effects of Transforming Growth Factor-Beta-1 (TGF-β1) in Autoimmune Diseases | Journal of Autoimmunity | 2000 | 258 |
| 30 | Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy. | American Journal of Respiratory and Critical Care Medicine | 1997 | 256 |
| 31 | Failure pattern following complete resection plus radiotherapy and temozolomide is at the resection margin in patients with glioblastoma | Journal of Neuro-Oncology | 2013 | 246 |
| 32 | Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16 | American Journal of Pathology | 1996 | 244 |
| 33 | THE EFFECT OF ALLOXAN DIABETES ON EXPERIMENTAL CHOLESTEROL ATHEROSCLEROSIS IN THE RABBIT | Journal of Experimental Medicine | 1949 | 235 |
| 34 | Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer | Histopathology | 2006 | 230 |
| 35 | Increased Endothelin-1 in Bleomycin-induced Pulmonary Fibrosis and the Effect of an Endothelin Receptor Antagonist | American Journal of Respiratory and Critical Care Medicine | 1997 | 227 |
| 36 | Treatment of intracranial ependymomas of children: review of a 15-year experience | International Journal of Radiation Oncology Biology Physics | 1994 | 212 |
| 37 | Prospective analysis of sensitivity and specificity of urinary cytology and other urinary biomarkers for bladder cancer | Urologic Oncology: Seminars and Original Investigations | 2015 | 212 |
| 38 | Demographic and pathological characteristics of serrated polyps of colorectum | Histopathology | 2005 | 207 |
| 39 | Selecting immunohistochemical cut-off scores for novel biomarkers of progression and survival in colorectal cancer | Journal of Clinical Pathology | 2007 | 197 |
| 40 | Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma | Nature Communications | 2016 | 197 |
| 41 | Developmental biology of annual fishes. I. Stages in the normal development ofAustrofundulus myersi Dahl | The Journal of Experimental Zoology | 1972 | 195 |
| 42 | Meta-analysis of Outcome of Cytomegalovirus Colitis in Immunocompetent Hosts | Digestive Diseases and Sciences | 2005 | 195 |
| 43 | Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas | Nature Genetics | 2017 | 195 |
| 44 | Epstein-barr virus related lymphoepithelioma-like carcinoma of lung | Journal of Surgical Oncology | 1987 | 192 |
| 45 | Analysis of PALB2/FANCN-associated breast cancer families | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 192 |
| 46 | H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas | Cancer Cell | 2017 | 192 |
| 47 | Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors | Cancer Cell | 2016 | 191 |
| 48 | Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 188 |
| 49 | Hyperplastic Polyposis Syndrome: Phenotypic Presentations and the Role of MBD4 and MYH | Gastroenterology | 2006 | 186 |
| 50 | Serrated adenoma of the colorectum and the DNA-methylator phenotype | Nature Clinical Practice Oncology | 2005 | 178 |
