| # | Title | Journal | Year | Citations |
|---|
| 1 | Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | Nature Genetics | 2008 | 2,422 |
| 2 | A reference panel of 64,976 haplotypes for genotype imputation | Nature Genetics | 2016 | 2,421 |
| 3 | Prevention of VTE in Nonsurgical Patients | Chest | 2012 | 1,780 |
| 4 | Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13 | Science | 1994 | 1,725 |
| 5 | Competency-based medical education: theory to practice | Medical Teacher | 2010 | 1,649 |
| 6 | Clinical classification of pulmonary hypertension | Journal of the American College of Cardiology | 2004 | 1,542 |
| 7 | Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4) | Journal of Experimental Medicine | 1999 | 1,473 |
| 8 | Immortal Time Bias in Pharmacoepidemiology | American Journal of Epidemiology | 2008 | 1,306 |
| 9 | Chronic Kidney Disease | Circulation | 2007 | 1,278 |
| 10 | PTH/PTHrP Receptor in Early Development and Indian Hedgehog--Regulated Bone Growth | Science | 1996 | 1,244 |
| 11 | Targeting potential drivers of COVID-19: Neutrophil extracellular traps | Journal of Experimental Medicine | 2020 | 1,193 |
| 12 | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture | Nature Genetics | 2012 | 1,100 |
| 13 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 14 | The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men | Nature Reviews Molecular Cell Biology | 2008 | 1,092 |
| 15 | An atlas of genetic influences on human blood metabolites | Nature Genetics | 2014 | 1,084 |
| 16 | Atrial Fibrosis: Mechanisms and Clinical Relevance in Atrial Fibrillation | Journal of the American College of Cardiology | 2008 | 1,044 |
| 17 | The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women | Osteoporosis International | 2007 | 1,017 |
| 18 | The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase | Science | 1999 | 963 |
| 19 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk | Nature Genetics | 2013 | 960 |
| 20 | Follicular Depletion During the Menopausal Transition: Evidence for Accelerated Loss and Ultimate Exhaustion* | Journal of Clinical Endocrinology and Metabolism | 1987 | 928 |
| 21 | Incidence, risk factors and consequences of ICU delirium | Intensive Care Medicine | 2007 | 869 |
| 22 | Clinical Practice Guidelines for the Management of Hypertension in the Community | Journal of Clinical Hypertension | 2014 | 768 |
| 23 | Immunologic Aspects of Chronic Obstructive Pulmonary Disease | New England Journal of Medicine | 2009 | 684 |
| 24 | Gait Speed as an Incremental Predictor of Mortality and Major Morbidity in Elderly Patients Undergoing Cardiac Surgery | Journal of the American College of Cardiology | 2010 | 645 |
| 25 | Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica | Prostaglandins | 1980 | 644 |
| 26 | Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer | Annals of Oncology | 2018 | 615 |
| 27 | ING Tumor Suppressor Proteins Are Critical Regulators of Chromatin Acetylation Required for Genome Expression and Perpetuation | Molecular Cell | 2006 | 589 |
| 28 | RNA-binding proteins in human genetic disease | Trends in Genetics | 2008 | 583 |
| 29 | Early Detection and Prediction of Cardiotoxicity in Chemotherapy-Treated Patients | American Journal of Cardiology | 2011 | 577 |
| 30 | Familial Adenomatous Polyposis | American Journal of Gastroenterology | 2006 | 575 |
| 31 | Neural control of mechanical ventilation in respiratory failure | Nature Medicine | 1999 | 573 |
| 32 | An atlas of genetic influences on osteoporosis in humans and mice | Nature Genetics | 2019 | 557 |
| 33 | Innate immunity to malaria | Nature Reviews Immunology | 2004 | 555 |
| 34 | Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition | Human Molecular Genetics | 2001 | 539 |
| 35 | The Quebec Back Pain Disability Scale | Spine | 1995 | 527 |
| 36 | Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer | Nature Genetics | 2015 | 513 |
| 37 | Completeness of reporting of trials published in languages other than English: implications for conduct and reporting of systematic reviews | Lancet, The | 1996 | 511 |
| 38 | A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX | Journal of Bone and Mineral Research | 2016 | 508 |
| 39 | Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. | Journal of Biological Chemistry | 1994 | 495 |
| 40 | The use of prescription claims databases in pharmacoepidemiological research: The accuracy and comprehensiveness of the prescription claims database in Québec | Journal of Clinical Epidemiology | 1995 | 494 |
| 41 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 42 | Risk of Nonaccidental and Cardiovascular Mortality in Relation to Long-term Exposure to Low Concentrations of Fine Particulate Matter: A Canadian National-Level Cohort Study | Environmental Health Perspectives | 2012 | 484 |
| 43 | Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture | Nature | 2015 | 483 |
| 44 | Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2018 | 474 |
| 45 | Mechanisms of Mammalian Iron Homeostasis | Biochemistry | 2012 | 465 |
| 46 | Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases | Immunity | 2010 | 461 |
| 47 | Is Breast Cancer the Same Disease in Asian and Western Countries? | World Journal of Surgery | 2010 | 460 |
| 48 | 2019 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer | Lancet Oncology, The | 2019 | 458 |
| 49 | Point-of-Care Testing for Infectious Diseases: Diversity, Complexity, and Barriers in Low- And Middle-Income Countries | PLoS Medicine | 2012 | 447 |
| 50 | Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation. | Journal of Cell Biology | 1994 | 443 |
