| # | Title | Journal | Year | Citations |
|---|
| 1 | Nrf2 signaling pathway: Pivotal roles in inflammation | Biochimica Et Biophysica Acta - Molecular Basis of Disease | 2017 | 1,223 |
| 2 | Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex | Nature | 2016 | 807 |
| 3 | Viscoelastic properties of individual glial cells and neurons in the CNS | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 473 |
| 4 | Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance | Autophagy | 2013 | 416 |
| 5 | Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs | Free Radical Biology and Medicine | 2011 | 270 |
| 6 | Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury | Autophagy | 2014 | 204 |
| 7 | Osteogenic fate of hypertrophic chondrocytes | Cell Research | 2014 | 151 |
| 8 | Reactive glial cells: increased stiffness correlates with increased intermediate filament expression | FASEB Journal | 2011 | 148 |
| 9 | Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke | Carcinogenesis | 2005 | 140 |
| 10 | Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo | Biochemical and Biophysical Research Communications | 2014 | 115 |
| 11 | Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin | Oncotarget | 2016 | 113 |
| 12 | Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives | European Journal of Medicinal Chemistry | 2009 | 103 |
| 13 | Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia | Neuroscience Letters | 2005 | 102 |
| 14 | An update for epilepsy research and antiepileptic drug development: Toward precise circuit therapy | Neuroscience Letters | 2019 | 102 |
| 15 | Angiopep‐Conjugated Electro‐Responsive Hydrogel Nanoparticles: Therapeutic Potential for Epilepsy | Angewandte Chemie - International Edition | 2014 | 101 |
| 16 | Montelukast, a Cysteinyl Leukotriene Receptor-1 Antagonist, Dose- and Time-Dependently Protects against Focal Cerebral Ischemia in Mice | Pharmacology | 2005 | 99 |
| 17 | Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy | Neuron | 2017 | 97 |
| 18 | The roles of histamine and its receptor ligands in central nervous system disorders: An update | Neuron | 2017 | 93 |
| 19 | Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate | Nature Communications | 2019 | 92 |
| 20 | Therapeutic potential of an anti-high mobility group box-1 monoclonal antibody in epilepsy | Brain, Behavior, and Immunity | 2017 | 90 |
| 21 | Increased expression of cysteinyl leukotriene receptor-1 in the brain mediates neuronal damage and astrogliosis after focal cerebral ischemia in rats | Neuroscience | 2006 | 86 |
| 22 | A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain | Nature Nanotechnology | 2020 | 83 |
| 23 | Noncovalent Dimerization of Ubiquitin | Angewandte Chemie - International Edition | 2012 | 80 |
| 24 | The Oxidation States of DJ-1 Dictate the Cell Fate in Response to Oxidative Stress Triggered by 4-HPR: Autophagy or Apoptosis? | Antioxidants and Redox Signaling | 2014 | 79 |
| 25 | Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population | European Journal of Clinical Pharmacology | 2006 | 75 |
| 26 | Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors | Bioorganic and Medicinal Chemistry | 2009 | 75 |
| 27 | Activation of CysLT receptors induces astrocyte proliferation and death after oxygen–glucose deprivation | Glia | 2008 | 74 |
| 28 | Expression of cysteinyl leukotriene receptor 1 in human traumatic brain injury and brain tumors | Neuroscience Letters | 2004 | 73 |
| 29 | Epirubicin-Loaded Superparamagnetic Iron-Oxide Nanoparticles for Transdermal Delivery: Cancer Therapy by Circumventing the Skin Barrier | Small | 2015 | 73 |
| 30 | A nuclear targeted Dox-aptamer loaded liposome delivery platform for the circumvention of drug resistance in breast cancer | Biomedicine and Pharmacotherapy | 2019 | 71 |
| 31 | AKT-ions with a TWIST between EMT and MET | Oncotarget | 2016 | 71 |
| 32 | The modulatory effects of the volatile oil of ginger on the cellular immune response in vitro and in vivo in mice | Journal of Ethnopharmacology | 2006 | 70 |
| 33 | PD-1 inhibitors increase the incidence and risk of pneumonitis in cancer patients in a dose-independent manner: a meta-analysis | Scientific Reports | 2017 | 70 |
| 34 | Role of Histamine and Its Receptors in Cerebral Ischemia | ACS Chemical Neuroscience | 2012 | 68 |
| 35 | Pranlukast, a cysteinyl leukotriene receptor-1 antagonist, protects against chronic ischemic brain injury and inhibits the glial scar formation in mice | Brain Research | 2005 | 67 |
| 36 | TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury | Free Radical Biology and Medicine | 2019 | 67 |
| 37 | Central Nervous System Involvement in ANCA-Associated Vasculitis: What Neurologists Need to Know | Frontiers in Neurology | 2018 | 67 |
| 38 | A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy | Nature Communications | 2020 | 67 |
| 39 | Minocycline protects PC12 cells from ischemic-like injury and inhibits 5-lipoxygenase activation | NeuroReport | 2004 | 66 |
| 40 | Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats | Acta Pharmacologica Sinica | 2006 | 66 |
| 41 | ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells | Free Radical Biology and Medicine | 2009 | 66 |
| 42 | Beneficial effects of the extract from Corydalis yanhusuo in rats with heart failure following myocardial infarction† | Journal of Pharmacy and Pharmacology | 2010 | 65 |
| 43 | Inhibition of G Protein‐Coupled Receptor 81 (GPR81) Protects Against Ischemic Brain Injury | CNS Neuroscience and Therapeutics | 2015 | 65 |
| 44 | Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking | Toxicology | 2004 | 64 |
| 45 | Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats | Acta Pharmacologica Sinica | 2007 | 64 |
| 46 | Dihydroartemisinin exerts cytotoxic effects and inhibits hypoxia inducible factor-1α activation in C6 glioma cells | Journal of Pharmacy and Pharmacology | 2010 | 63 |
| 47 | Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols | Chemico-Biological Interactions | 2011 | 63 |
| 48 | Macrophage‐Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention | Advanced Functional Materials | 2021 | 63 |
| 49 | Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms | Nature Communications | 2014 | 62 |
| 50 | Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs | Free Radical Biology and Medicine | 2014 | 62 |
