| Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays | Journal of Molecular Endocrinology | 2000 | 3K |
| Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease | American Journal of Respiratory and Critical Care Medicine | 2000 | 866 |
| The EPICure study: outcomes to discharge from hospital for infants born at the threshold of viability | Pediatrics | 2000 | 673 |
| Adrenomedullin, a multifunctional regulatory peptide | Endocrine Reviews | 2000 | 575 |
| Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma | Human Molecular Genetics | 2000 | 560 |
| Functional regeneration of sensory axons into the adult spinal cord | Nature | 2000 | 448 |
| Heat related mortality in warm and cold regions of Europe: observational study | BMJ: British Medical Journal | 2000 | 241 |
| Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism | British Journal of Pharmacology | 2000 | 227 |
| One-year treatment of obesity: a randomized, double-blind, placebo-controlled, multicentre study of orlistat, a gastrointestinal lipase inhibitor | International Journal of Obesity | 2000 | 217 |
| Guidelines for the prevention of falls in people over 65. The Guidelines' Development Group | BMJ: British Medical Journal | 2000 | 188 |
| Linear discriminant analysis of symptoms in patients with chronic constipation: validation of a new scoring system (KESS) | Diseases of the Colon and Rectum | 2000 | 161 |
| Polymorphisms in the IL-1A gene are correlated with levels of interleukin-1alpha protein in gingival crevicular fluid of teeth with severe periodontal disease | Journal of Dental Research | 2000 | 155 |
| Noise and health in the urban environment | Reviews on Environmental Health | 2000 | 150 |
| Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding | Diabetes | 2000 | 146 |
| Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels | Thrombosis and Haemostasis | 2000 | 145 |
| Saliva tannin interactions | Journal of Oral Rehabilitation | 2000 | 135 |
| Early-life programming of susceptibility to dysregulation of glucose metabolism and the development of Type 2 diabetes mellitus | Biochemical Journal | 2000 | 114 |
| Quality of life in first-admitted schizophrenia patients: a follow-up study | Psychological Medicine | 2000 | 104 |
| Evidence-based medicine as Bayesian decision-making | Statistics in Medicine | 2000 | 97 |
| Imipramine and phenelzine decrease glutamate overflow in the prefrontal cortex--a possible mechanism of neuroprotection in major depression? | Neuroscience | 2000 | 97 |
| Regular inhaled salbutamol and asthma control: the TRUST randomised trial. Therapy Working Group of the National Asthma Task Force and the MRC General Practice Research Framework | Lancet, The | 2000 | 91 |
| Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression | Biochemical Journal | 2000 | 87 |
| Registration of ovarian cancer in England and Wales | British Journal of Cancer | 2000 | 78 |
| Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin | Diabetologia | 2000 | 71 |
| The ALS Health Profile Study: quality of life of amyotrophic lateral sclerosis patients and carers in Europe | Journal of Neurology | 2000 | 66 |
