| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 2 | Worldwide prevalence and risk factors for myopia | Ophthalmic and Physiological Optics | 2012 | 624 |
| 3 | Risk Factors for Severe Outcomes following 2009 Influenza A (H1N1) Infection: A Global Pooled Analysis | PLoS Medicine | 2011 | 581 |
| 4 | Efficacy Comparison of 16 Interventions for Myopia Control in Children | Ophthalmology | 2016 | 521 |
| 5 | Autologous Bone Marrow–Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation | American Journal of Sports Medicine | 2010 | 510 |
| 6 | A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma | Nature Genetics | 2010 | 453 |
| 7 | Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children | PLoS Medicine | 2011 | 446 |
| 8 | Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men | Diabetologia | 2010 | 405 |
| 9 | Autophagic cell death: Loch Ness monster or endangered species? | Autophagy | 2011 | 298 |
| 10 | A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B | Nature Genetics | 2010 | 245 |
| 11 | Myopia-Related Optic Disc and Retinal Changes in Adolescent Children from Singapore | Ophthalmology | 2011 | 217 |
| 12 | Revisiting Mendelian disorders through exome sequencing | Human Genetics | 2011 | 206 |
| 13 | Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy | Autophagy | 2009 | 200 |
| 14 | Identification of New Genetic Risk Variants for Type 2 Diabetes | PLoS Genetics | 2010 | 193 |
| 15 | The pursuit of genome-wide association studies: where are we now? | Journal of Human Genetics | 2010 | 191 |
| 16 | Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1 | Nature Genetics | 2011 | 181 |
| 17 | Application of Advanced Statistics in Ophthalmology | | 2011 | 181 |
| 18 | A study on Singaporean women's acceptance of using mobile phones to seek health information | International Journal of Medical Informatics | 2011 | 179 |
| 19 | zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC–MAPKs–AP-1 pathway | Cell Death and Differentiation | 2011 | 160 |
| 20 | Exome sequencing: Dual role as a discovery and diagnostic tool | Annals of Neurology | 2012 | 157 |
| 21 | Body Mass Index and Diabetes in Asia: A Cross-Sectional Pooled Analysis of 900,000 Individuals in the Asia Cohort Consortium | PLoS ONE | 2011 | 154 |
| 22 | Using Instrument-Defined Health State Transitions to Estimate Minimally Important Differences for Four Preference-Based Health-Related Quality of Life Instruments | Medical Care | 2010 | 150 |
| 23 | Family history, near work, outdoor activity, and myopia in Singapore Chinese preschool children | British Journal of Ophthalmology | 2010 | 132 |
| 24 | Breast cancer in a multi-ethnic Asian setting: Results from the Singapore–Malaysia hospital-based breast cancer registry | Breast | 2011 | 115 |
| 25 | Statistical Analysis of Illness–Death Processes and Semicompeting Risks Data | Biometrics | 2010 | 110 |
| 26 | Studying the epigenome using next generation sequencing | Journal of Medical Genetics | 2011 | 108 |
| 27 | Smoking as an independent risk factor for hepatocellular carcinoma: the Singapore Chinese Health Study | British Journal of Cancer | 2011 | 107 |
| 28 | Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis | Autophagy | 2012 | 107 |
| 29 | Building Caries Risk Assessment Models for Children | Journal of Dental Research | 2010 | 104 |
| 30 | Ethnicity Modifies the Relationships of Insulin Resistance, Inflammation, and Adiponectin With Obesity in a Multiethnic Asian Population | Diabetes Care | 2011 | 104 |
| 31 | Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin | Biochemical Pharmacology | 2010 | 103 |
| 32 | Differences in Prevalence of Refractive Errors in Young Asian Males in Singapore between 1996–1997 and 2009–2010 | Ophthalmic Epidemiology | 2014 | 101 |
| 33 | Skin cancer trends among Asians living in Singapore from 1968 to 2006 | Journal of the American Academy of Dermatology | 2009 | 99 |
| 34 | Dietary Patterns and Incident Type 2 Diabetes in Chinese Men and Women | Diabetes Care | 2011 | 99 |
| 35 | Regions of homozygosity and their impact on complex diseases and traits | Human Genetics | 2011 | 98 |
| 36 | Diabetes and Risk of Hip Fracture in the Singapore Chinese Health Study | Diabetes Care | 2010 | 92 |
| 37 | Prevalence and Risk Factors for Refractive Errors in Indians: The Singapore Indian Eye Study (SINDI) | | 2011 | 91 |
| 38 | Gender-specific Associations Between Soy and Risk of Hip Fracture in the Singapore Chinese Health Study | American Journal of Epidemiology | 2009 | 90 |
| 39 | The discovery of human genetic variations and their use as disease markers: past, present and future | Journal of Human Genetics | 2010 | 89 |
| 40 | Chrysin sensitizes tumor necrosis factor-α-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB | Cancer Letters | 2010 | 89 |
| 41 | Soy intake and risk of type 2 diabetes mellitus in Chinese Singaporeans | European Journal of Nutrition | 2012 | 87 |
| 42 | MSblender: A Probabilistic Approach for Integrating Peptide Identifications from Multiple Database Search Engines | Journal of Proteome Research | 2011 | 86 |
| 43 | Human genetics and genomics a decade after the release of the draft sequence of the human genome | Human Genomics | 2011 | 86 |
| 44 | Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation | Cell Death and Differentiation | 2010 | 84 |
| 45 | Enhanced Autophagy from Chronic Toxicity of Iron and Mutant A53T α-Synuclein | Journal of Biological Chemistry | 2011 | 82 |
| 46 | Bariatric Surgery in Asia in the Last 5 Years (2005–2009) | Obesity Surgery | 2012 | 82 |
| 47 | Coffee consumption and reduced risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study | Cancer Causes and Control | 2011 | 79 |
| 48 | Polymorphisms Identified through Genome-Wide Association Studies and Their Associations with Type 2 Diabetes in Chinese, Malays, and Asian-Indians in Singapore | Journal of Clinical Endocrinology and Metabolism | 2010 | 77 |
| 49 | Are Myopic Eyes Less Likely to Have Diabetic Retinopathy? | Ophthalmology | 2010 | 76 |
| 50 | Clinicopathological significance of calreticulin in breast invasive ductal carcinoma | Modern Pathology | 2010 | 75 |
