| # | Title | Journal | Year | Citations |
|---|
| 1 | SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls | Nature | 2020 | 1,744 |
| 2 | A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID-19 outbreak | Brain, Behavior, and Immunity | 2020 | 1,165 |
| 3 | The genetic architecture of type 2 diabetes | Nature | 2016 | 952 |
| 4 | Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study | Gastroenterology | 2021 | 913 |
| 5 | Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression | Journal of Affective Disorders | 2012 | 759 |
| 6 | Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity | Nature | 2017 | 743 |
| 7 | Big data and machine learning algorithms for health-care delivery | Lancet Oncology, The | 2019 | 733 |
| 8 | Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches | Science | 2019 | 676 |
| 9 | An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element | Science | 2014 | 665 |
| 10 | Epidemiology of COVID‐19: A systematic review and meta‐analysis of clinical characteristics, risk factors, and outcomes | Journal of Medical Virology | 2021 | 450 |
| 11 | Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children | PLoS Medicine | 2011 | 446 |
| 12 | The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease | Hepatology International | 2020 | 422 |
| 13 | Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men | Diabetologia | 2010 | 405 |
| 14 | Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency | Immunity | 2017 | 380 |
| 15 | A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci | Nature Genetics | 2010 | 374 |
| 16 | The global prevalence of IBS in adults remains elusive due to the heterogeneity of studies: a Rome Foundation working team literature review | Gut | 2017 | 368 |
| 17 | Asia–Pacific Working Party on Non‐alcoholic Fatty Liver Disease guidelines 2017—Part 1: Definition, risk factors and assessment | Journal of Gastroenterology and Hepatology (Australia) | 2018 | 358 |
| 18 | Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer | PLoS Genetics | 2009 | 354 |
| 19 | A global scientific strategy to cure hepatitis B | The Lancet Gastroenterology and Hepatology | 2019 | 342 |
| 20 | Fast and sensitive mapping of nanopore sequencing reads with GraphMap | Nature Communications | 2016 | 331 |
| 21 | Asia Pacific consensus recommendations for colorectal cancer screening | Gut | 2008 | 307 |
| 22 | Residual Embryonic Cells as Precursors of a Barrett's-like Metaplasia | Cell | 2011 | 292 |
| 23 | Serum autoantibodies as biomarkers for early cancer detection | FEBS Journal | 2009 | 272 |
| 24 | Practice of endoscopy during COVID-19 pandemic: position statements of the Asian Pacific Society for Digestive Endoscopy (APSDE-COVID statements) | Gut | 2020 | 264 |
| 25 | Role of the miR‐106b‐25 microRNA cluster in hepatocellular carcinoma | Cancer Science | 2009 | 262 |
| 26 | 2019 Global NAFLD Prevalence: A Systematic Review and Meta-analysis | Clinical Gastroenterology and Hepatology | 2022 | 255 |
| 27 | Efficacy of covid-19 vaccines in immunocompromised patients: systematic review and meta-analysis | BMJ, The | 2022 | 253 |
| 28 | Characteristics and outcomes of culture-negative versus culture-positive severe sepsis | Critical Care | 2013 | 250 |
| 29 | Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls | Nature | 2019 | 248 |
| 30 | A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B | Nature Genetics | 2010 | 245 |
| 31 | Mutations in Potassium Channel Kir2.6 Cause Susceptibility to Thyrotoxic Hypokalemic Periodic Paralysis | Cell | 2010 | 245 |
| 32 | Axonal Guillain-Barré syndrome: concepts and controversies | Lancet Neurology, The | 2013 | 244 |
| 33 | Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus | Gut | 2020 | 239 |
| 34 | GFR Estimating Equations in a Multiethnic Asian Population | American Journal of Kidney Diseases | 2011 | 225 |
| 35 | Right ventricular dysfunction in left‐sided heart failure with preserved versus reduced ejection fraction | European Journal of Heart Failure | 2017 | 224 |
| 36 | Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: a meta-analysis of randomized controlled trials and meta-regression | Rheumatology | 2010 | 221 |
| 37 | The rise of chronic non-communicable diseases in southeast Asia: time for action | Lancet, The | 2011 | 220 |
| 38 | Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease | Nature Genetics | 2017 | 218 |
| 39 | Determinants of burnout and other aspects of psychological well-being in healthcare workers during the Covid-19 pandemic: A multinational cross-sectional study | PLoS ONE | 2021 | 215 |
| 40 | COVID-19 and ischemic stroke: a systematic review and meta-summary of the literature | Journal of Thrombosis and Thrombolysis | 2020 | 214 |
| 41 | Prevalence of Burnout in Medical and Surgical Residents: A Meta-Analysis | International Journal of Environmental Research and Public Health | 2019 | 210 |
| 42 | The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML | Blood | 2011 | 205 |
| 43 | Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination | Nature Communications | 2018 | 205 |
| 44 | Bickerstaff brainstem encephalitis and Fisher syndrome: anti-GQ1b antibody syndrome | Journal of Neurology, Neurosurgery and Psychiatry | 2013 | 199 |
| 45 | Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets | Nature | 2017 | 189 |
| 46 | Differential Targeting of Viral Components by CD4+versus CD8+T Lymphocytes in Dengue Virus Infection | Journal of Virology | 2013 | 188 |
| 47 | Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism | Cell Metabolism | 2016 | 186 |
| 48 | NTM drug discovery: status, gaps and the way forward | Drug Discovery Today | 2018 | 186 |
| 49 | A Fully Fabric-Based Bidirectional Soft Robotic Glove for Assistance and Rehabilitation of Hand Impaired Patients | IEEE Robotics and Automation Letters | 2017 | 178 |
| 50 | Asian-Pacific Association for the Study of the Liver (APASL) consensus guidelines on invasive and non-invasive assessment of hepatic fibrosis: a 2016 update | Hepatology International | 2017 | 178 |
