Department of Medicine and Pathology

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#	Title	Journal	Year	Citations
1	The multilayered complexity of ceRNA crosstalk and competition	Nature	2014	3,223
2	The functions and regulation of the PTEN tumour suppressor: new modes and prospects	Nature Reviews Molecular Cell Biology	2018	566
3	Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity	Cell	2015	504
4	mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide	Nature	2017	503
5	The BRAF Pseudogene Functions as a Competitive Endogenous RNA and Induces Lymphoma In Vivo	Cell	2015	293
6	Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function	Cell	2014	235
7	An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer	Nature Genetics	2018	229
8	Acute Promyelocytic Leukemia: A Paradigm for Oncoprotein-Targeted Cure	Cancer Cell	2017	219
9	Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance	Cell Stem Cell	2014	172
10	SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression	Molecular Cell	2015	172
11	PTEN ceRNA networks in human cancer	Methods	2015	121
12	PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2	Molecular Cell	2016	120
13	Mouse hospital and co-clinical trial project—from bench to bedside	Nature Reviews Clinical Oncology	2015	109
14	Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program	Acta Neuropathologica	2019	106
15	Vulnerabilities of PTEN–TP53-Deficient Prostate Cancers to Compound PARP–PI3K Inhibition	Cancer Discovery	2014	88
16	PTEN mediates Notch-dependent stalk cell arrest in angiogenesis	Nature Communications	2015	86
17	Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita	Nature Genetics	2019	84
18	G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L	ELife	2015	80
19	Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs	Genome Biology	2021	75
20	Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma	Molecular Cell	2016	71
21	BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP	Leukemia	2014	67
22	The Tug1 lncRNA locus is essential for male fertility	Genome Biology	2020	61
23	Distinct germline progenitor subsets defined through Tsc2– mTORC 1 signaling	EMBO Reports	2015	58
24	The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function	Cancer Discovery	2017	57
25	LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control	Nature Cell Biology	2020	56
26	miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells	Journal of Experimental and Clinical Cancer Research	2019	55
27	PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression	Nature Communications	2019	53
28	SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression	Developmental Cell	2019	53
29	Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle	Cell Research	2021	51
30	A Unified Nomenclature and Amino Acid Numbering for Human PTEN	Science Signaling	2014	50
31	Characterization of Dual PTEN and p53-Targeting MicroRNAs Identifies MicroRNA-638/Dnm2 as a Two-Hit Oncogenic Locus	Cell Reports	2014	49
32	Role of aberrant PI3K pathway activation in gallbladder tumorigenesis	Oncotarget	2014	47
33	A circular twist on microRNA regulation	Cell Research	2017	46
34	Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling	Cell Communication and Signaling	2019	43
35	Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion	Biochimica Et Biophysica Acta: Reviews on Cancer	2018	42
36	Aberrant ceRNA activity drives lung cancer	Cell Research	2014	41
37	The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis	Nucleic Acids Research	2020	40
38	Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism	Nature Communications	2018	39
39	TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFβ signaling activation	Cell Death and Differentiation	2015	36
40	A co-clinical platform to accelerate cancer treatment optimization	Trends in Molecular Medicine	2015	34
41	The PTEN Tumor Suppressor Forms Homodimers in Solution	Structure	2015	30
42	The Tumor Suppressor PML Specifically Accumulates at RPA/Rad51-Containing DNA Damage Repair Foci but Is Nonessential for DNA Damage-Induced Fibroblast Senescence	Molecular and Cellular Biology	2014	26
43	BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation	Cell Cycle	2015	26
44	The Interplay Between the Genetic and Immune Landscapes of AML: Mechanisms and Implications for Risk Stratification and Therapy	Frontiers in Oncology	2019	25
45	Therapeutic Potential of Targeting the SUMO Pathway in Cancer	Cancers	2021	25
46	Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis	Cancer Discovery	2015	24
47	The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer	Molecular Cancer Research	2018	24
48	Bone Marrow Endosteal Mesenchymal Progenitors Depend on HIF Factors for Maintenance and Regulation of Hematopoiesis	Stem Cell Reports	2014	23
49	SPAR, a lncRNA encoded mTORC1 inhibitor	Cell Cycle	2017	22
50	The Mouse Hospital and Its Integration in Ultra-Precision Approaches to Cancer Care	Frontiers in Oncology	2018	20

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