| # | Title | Journal | Year | Citations |
|---|
| 1 | Pancreatic cancer | Lancet, The | 2011 | 2,155 |
| 2 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 3 | Pancreatic cancer | Lancet, The | 2016 | 1,826 |
| 4 | The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2006 | 1,795 |
| 5 | Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions | American Journal of Transplantation | 2008 | 1,710 |
| 6 | Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease | Nature Genetics | 2011 | 1,676 |
| 7 | Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma | Cancer Cell | 2014 | 1,616 |
| 8 | HPV-associated head and neck cancer: a virus-related cancer epidemic | Lancet Oncology, The | 2010 | 1,533 |
| 9 | Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo | Neuron | 1996 | 1,471 |
| 10 | The 2017 Bethesda System for Reporting Thyroid Cytopathology | Thyroid | 2017 | 1,319 |
| 11 | Resected adenocarcinoma of the pancreas?616 patients: results, outcomes, and prognostic indicators | Journal of Gastrointestinal Surgery | 2000 | 1,318 |
| 12 | The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints | Cancer Discovery | 2015 | 1,180 |
| 13 | Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma | Nature Genetics | 1994 | 1,063 |
| 14 | The Molecular Basis of Turcot's Syndrome | New England Journal of Medicine | 1995 | 1,060 |
| 15 | An Illustrated Consensus on the Classification of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms | American Journal of Surgical Pathology | 2004 | 964 |
| 16 | Multiple-laboratory comparison of microarray platforms | Nature Methods | 2005 | 814 |
| 17 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 18 | Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis | Nature Medicine | 2013 | 780 |
| 19 | C9orf72 nucleotide repeat structures initiate molecular cascades of disease | Nature | 2014 | 779 |
| 20 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation | Human Pathology | 2001 | 776 |
| 21 | Common genetic variants influence human subcortical brain structures | Nature | 2015 | 772 |
| 22 | Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability | Nature Genetics | 1995 | 759 |
| 23 | Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4 | Science | 1991 | 739 |
| 24 | Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria | Science | 2018 | 733 |
| 25 | Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms | Nature | 2002 | 724 |
| 26 | Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain | PLoS Genetics | 2010 | 722 |
| 27 | Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene | Science | 2009 | 713 |
| 28 | Banff ’09 Meeting Report: Antibody Mediated Graft Deterioration and Implementation of Banff Working Groups | American Journal of Transplantation | 2010 | 691 |
| 29 | Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin [published erratum appears in Hum Mol Genet 1999 May;8(5):943] | Human Molecular Genetics | 1999 | 687 |
| 30 | Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer | Cancer Discovery | 2018 | 676 |
| 31 | Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program | Cell | 2013 | 652 |
| 32 | Biological Properties of Curcumin-Cellular and Molecular Mechanisms of Action | Critical Reviews in Food Science and Nutrition | 2004 | 634 |
| 33 | Progression model for pancreatic cancer | Clinical Cancer Research | 2000 | 630 |
| 34 | Control of PD-L1 Expression by Oncogenic Activation of the AKT–mTOR Pathway in Non–Small Cell Lung Cancer | Cancer Research | 2016 | 595 |
| 35 | Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas | Nature Genetics | 2013 | 564 |
| 36 | COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 562 |
| 37 | NOTCH Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts | Stem Cells | 2010 | 553 |
| 38 | Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements | Nature Genetics | 2010 | 539 |
| 39 | Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice | Journal of Experimental Medicine | 2005 | 529 |
| 40 | Pituitary Expression of CTLA-4 Mediates Hypophysitis Secondary to Administration of CTLA-4 Blocking Antibody | Science Translational Medicine | 2014 | 526 |
| 41 | Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems | Acta Neuropathologica | 2012 | 525 |
| 42 | Tumor-suppressive pathways in pancreatic carcinoma | Cancer Research | 1997 | 525 |
| 43 | Factors influencing survival after pancreaticoduodenectomy for pancreatic cancer | American Journal of Surgery | 1991 | 519 |
| 44 | Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity | Science | 2020 | 511 |
| 45 | Combinatorial chemoprevention of intestinal neoplasia | Nature Medicine | 2000 | 495 |
| 46 | Screening for Early Pancreatic Neoplasia in High-Risk Individuals: A Prospective Controlled Study | Clinical Gastroenterology and Hepatology | 2006 | 493 |
| 47 | Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway | PLoS Genetics | 2012 | 489 |
| 48 | Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas | Cancer Research | 1996 | 484 |
| 49 | Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice | Nature Medicine | 2005 | 471 |
| 50 | Male Circumcision for the Prevention of HSV-2 and HPV Infections and Syphilis | New England Journal of Medicine | 2009 | 461 |
