| # | Title | Journal | Year | Citations |
|---|
| 1 | Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council | Journal of Pain | 2016 | 2,040 |
| 2 | The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises | Pain | 2020 | 1,880 |
| 3 | Efficacy of Postoperative Epidural Analgesia | JAMA - Journal of the American Medical Association | 2003 | 860 |
| 4 | Peripheral and central mechanisms of cutaneous hyperalgesia | Progress in Neurobiology | 1992 | 819 |
| 5 | Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids | Science | 2000 | 767 |
| 6 | Gender-Linked Brain Injury in Experimental Stroke | Stroke | 1998 | 697 |
| 7 | Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus | Cell | 2009 | 681 |
| 8 | Does Continuous Peripheral Nerve Block Provide Superior Pain Control to Opioids? A Meta-Analysis | Anesthesia and Analgesia | 2006 | 641 |
| 9 | Efficacy of Continuous Wound Catheters Delivering Local Anesthetic for Postoperative Analgesia: A Quantitative and Qualitative Systematic Review of Randomized Controlled Trials | Journal of the American College of Surgeons | 2006 | 481 |
| 10 | A subpopulation of nociceptors specifically linked to itch | Nature Neuroscience | 2013 | 477 |
| 11 | Efficacy of Postoperative Patient-controlled and Continuous Infusion Epidural Analgesia versus Intravenous Patient-controlled Analgesia with Opioids | Anesthesiology | 2005 | 438 |
| 12 | Sustaining reductions in catheter related bloodstream infections in Michigan intensive care units: observational study | BMJ: British Medical Journal | 2010 | 432 |
| 13 | Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors | Nature | 2009 | 392 |
| 14 | Astrocytes and the regulation of cerebral blood flow | Trends in Neurosciences | 2009 | 392 |
| 15 | Leptin Prevents Respiratory Depression in Obesity | American Journal of Respiratory and Critical Care Medicine | 1999 | 366 |
| 16 | Placebo‐Controlled Pilot Study of Centromedian Thalamic Stimulation in Treatment of Intractable Seizures | Epilepsia | 1992 | 344 |
| 17 | Effects of Perioperative Central Neuraxial Analgesia on Outcome after Coronary Artery Bypass Surgery | Anesthesiology | 2004 | 339 |
| 18 | Local analgesic effect of endogenous opioid peptides | Lancet, The | 1993 | 334 |
| 19 | Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41 | Physiological Genomics | 2016 | 299 |
| 20 | Peripheral Mechanisms of Somatic Pain | Anesthesiology | 1988 | 287 |
| 21 | Immune cell-derived beta-endorphin. Production, release, and control of inflammatory pain in rats. | Journal of Clinical Investigation | 1997 | 274 |
| 22 | The impact of obesity on outcomes after critical illness: a meta-analysis | Intensive Care Medicine | 2009 | 272 |
| 23 | Teamwork in the Operating Room | Anesthesiology | 2006 | 270 |
| 24 | Relative contribution of core and cutaneous temperatures to thermal comfort and autonomic responses in humans | Journal of Applied Physiology | 1999 | 266 |
| 25 | Role of astrocytes in cerebrovascular regulation | Journal of Applied Physiology | 2006 | 257 |
| 26 | Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages | | 1997 | 248 |
| 27 | Annual Incidence of Adult and Pediatric In-Hospital Cardiac Arrest in the United States | Circulation: Cardiovascular Quality and Outcomes | 2019 | 243 |
| 28 | Frailty for Surgeons: Review of a National Institute on Aging Conference on Frailty for Specialists | Journal of the American College of Surgeons | 2015 | 229 |
| 29 | Spinal Cord Stimulation: Clinical Efficacy and Potential Mechanisms | Pain Practice | 2018 | 225 |
| 30 | Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors | Journal of Experimental Medicine | 2012 | 224 |
| 31 | Intensive care unit safety culture and outcomes: a US multicenter study | International Journal for Quality in Health Care | 2010 | 221 |
| 32 | Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery | JAMA Surgery | 2017 | 217 |
| 33 | Sex, Gender, and Pain: An Overview of a Complex Field | Anesthesia and Analgesia | 2008 | 207 |
| 34 | Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage | Molecular Neurobiology | 2017 | 207 |
| 35 | The Flavanol (−)-Epicatechin Prevents Stroke Damage through the Nrf2/HO1 Pathway | Journal of Cerebral Blood Flow and Metabolism | 2010 | 206 |
| 36 | Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat | Neuroscience | 1996 | 197 |
| 37 | Systematic review identifies number of strategies important for retaining study participants | Journal of Clinical Epidemiology | 2007 | 192 |
| 38 | Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates | Cell Metabolism | 2014 | 186 |
| 39 | Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage | Progress in Neurobiology | 2019 | 185 |
| 40 | Preventing chronic pain following acute pain: Risk factors, preventive strategies, and their efficacy | European Journal of Pain Supplements | 2011 | 180 |
| 41 | No tolerance to peripheral morphine analgesia in presence of opioid expression in inflamed synovia. | Journal of Clinical Investigation | 1996 | 177 |
| 42 | Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage | Free Radical Biology and Medicine | 2012 | 172 |
| 43 | Potential Mechanism by Which Resveratrol, a Red Wine Constituent, Protects Neurons | Annals of the New York Academy of Sciences | 2003 | 170 |
| 44 | Development and validation of outcome prediction models for aneurysmal subarachnoid haemorrhage: the SAHIT multinational cohort study | BMJ: British Medical Journal | 2018 | 166 |
| 45 | Pain control in inflammation governed by selectins | Nature Medicine | 1998 | 164 |
| 46 | In Situ Simulation in Continuing Education for the Health Care Professions: A Systematic Review | Journal of Continuing Education in the Health Professions | 2012 | 163 |
| 47 | Risk Factors for Physical Impairment after Acute Lung Injury in a National, Multicenter Study | American Journal of Respiratory and Critical Care Medicine | 2014 | 162 |
| 48 | Variation in caregiver perceptions of teamwork climate in labor and delivery units | Journal of Perinatology | 2006 | 160 |
| 49 | Conventional and Kilohertz-frequency Spinal Cord Stimulation Produces Intensity- and Frequency-dependent Inhibition of Mechanical Hypersensitivity in a Rat Model of Neuropathic Pain | Anesthesiology | 2013 | 160 |
| 50 | Knockdown of Arginase I Restores NO Signaling in the Vasculature of Old Rats | Hypertension | 2006 | 157 |
