| # | Title | Journal | Year | Citations |
|---|
| 1 | Multilineage Potential of Adult Human Mesenchymal Stem Cells | Science | 1999 | 18,830 |
| 2 | Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype | Nature Biotechnology | 2019 | 6,567 |
| 3 | Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors | Advances in Enzyme Regulation | 1984 | 6,213 |
| 4 | Whole-genome random sequencing and assembly of Haemophilus influenzae Rd | Science | 1995 | 5,619 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 6 | An Intervention to Decrease Catheter-Related Bloodstream Infections in the ICU | New England Journal of Medicine | 2006 | 4,369 |
| 7 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
| 8 | The Hopkins Symptom Checklist (HSCL): A self-report symptom inventory | Systems Research and Behavioral Science | 1974 | 3,952 |
| 9 | Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member | Nature | 1997 | 3,596 |
| 10 | The complete genome sequence of the gastric pathogen Helicobacter pylori | Nature | 1997 | 3,405 |
| 11 | Untangling the Concepts of Disability, Frailty, and Comorbidity: Implications for Improved Targeting and Care | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2004 | 3,002 |
| 12 | Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress | New England Journal of Medicine | 2005 | 2,766 |
| 13 | A model for p53-induced apoptosis | Nature | 1997 | 2,392 |
| 14 | Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions | Neuron | 2011 | 2,193 |
| 15 | Nitric Oxide: A Physiologic Messenger Molecule | Annual Review of Biochemistry | 1994 | 2,175 |
| 16 | The Development of Human Benign Prostatic Hyperplasia with Age | Journal of Urology | 1984 | 2,145 |
| 17 | Clinical Practice Guidelines and Quality of Care for Older Patients With Multiple Comorbid Diseases | JAMA - Journal of the American Medical Association | 2005 | 2,083 |
| 18 | Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU | Critical Care Medicine | 2018 | 2,074 |
| 19 | Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A | Science | 1991 | 2,042 |
| 20 | Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy | Nature Medicine | 1999 | 1,962 |
| 21 | Use of Carotid Ultrasound to Identify Subclinical Vascular Disease and Evaluate Cardiovascular Disease Risk: A Consensus Statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force Endorsed by the Society for Vascular Medicine | Journal of the American Society of Echocardiography | 2008 | 1,941 |
| 22 | TFOS DEWS II Definition and Classification Report | Ocular Surface | 2017 | 1,932 |
| 23 | Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection | Nature | 1997 | 1,921 |
| 24 | The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises | Pain | 2020 | 1,880 |
| 25 | Load Independence of the Instantaneous Pressure-Volume Ratio of the Canine Left Ventricle and Effects of Epinephrine and Heart Rate on the Ratio | Circulation Research | 1973 | 1,711 |
| 26 | Prevalence of Neuropsychiatric Symptoms in Dementia and Mild Cognitive Impairment | JAMA - Journal of the American Medical Association | 2002 | 1,676 |
| 27 | Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 1,650 |
| 28 | Clinical practice guidelines for antimicrobial prophylaxis in surgery | American Journal of Health-System Pharmacy | 2013 | 1,643 |
| 29 | HPV-associated head and neck cancer: a virus-related cancer epidemic | Lancet Oncology, The | 2010 | 1,533 |
| 30 | ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee | Journal of the American College of Radiology | 2017 | 1,473 |
| 31 | Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo | Neuron | 1996 | 1,471 |
| 32 | Principles of Diffusion Tensor Imaging and Its Applications to Basic Neuroscience Research | Neuron | 2006 | 1,467 |
| 33 | Reproducibility of quantitative tractography methods applied to cerebral white matter | NeuroImage | 2007 | 1,464 |
| 34 | Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase | Neuron | 1991 | 1,390 |
| 35 | RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs | Cell | 1994 | 1,355 |
| 36 | Organization of the retina of the mudpuppy, Necturus maculosus. II. Intracellular recording. | Journal of Neurophysiology | 1969 | 1,332 |
| 37 | Biomedical applications of polymer-composite materials: a review | Composites Science and Technology | 2001 | 1,260 |
| 38 | Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins | Nature | 2007 | 1,246 |
| 39 | Potential metal-binding domains in nucleic acid binding proteins | Science | 1986 | 1,219 |
| 40 | Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain | Cell | 2011 | 1,196 |
| 41 | Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores | Nature | 1989 | 1,176 |
| 42 | Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens | Science | 1994 | 1,127 |
| 43 | Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity | Nature Reviews Immunology | 2004 | 1,110 |
| 44 | Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease | Annual Review of Biochemistry | 2011 | 1,081 |
| 45 | The Molecular Basis of Turcot's Syndrome | New England Journal of Medicine | 1995 | 1,060 |
| 46 | Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. | American Journal of Respiratory Cell and Molecular Biology | 1996 | 1,060 |
| 47 | Human L1 Retrotransposon Encodes a Conserved Endonuclease Required for Retrotransposition | Cell | 1996 | 1,048 |
| 48 | Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer | Nature | 2003 | 1,026 |
| 49 | Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation | Nature | 1989 | 1,019 |
| 50 | Paraneoplastic Pemphigus | New England Journal of Medicine | 1990 | 1,018 |
