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#	Title	Journal	Year	Citations
1	Microbial Hub Taxa Link Host and Abiotic Factors to Plant Microbiome Variation	PLoS Biology	2016	1,065
2	A guide to genome engineering with programmable nucleases	Nature Reviews Genetics	2014	990
3	DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins	Nature Biotechnology	2015	975
4	Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells	Nature Methods	2015	850
5	Correction of a pathogenic gene mutation in human embryos	Nature	2017	781
6	CRISPR/Cpf1-mediated DNA-free plant genome editing	Nature Communications	2017	386
7	Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy	Nature Biotechnology	2018	345
8	Microhomology-based choice of Cas9 nuclease target sites	Nature Methods	2014	336
9	Highly efficient RNA-guided base editing in mouse embryos	Nature Biotechnology	2017	330
10	Cas-analyzer: an online tool for assessing genome editing results using NGS data	Bioinformatics	2017	313
11	DNA-free two-gene knockout in Chlamydomonas reinhardtii via CRISPR-Cas9 ribonucleoproteins	Scientific Reports	2016	253
12	Precision genome engineering through adenine base editing in plants	Nature Plants	2018	227
13	Targeted mutagenesis in mice by electroporation of Cpf1 ribonucleoproteins	Nature Biotechnology	2016	191
14	Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq	Genome Research	2016	184
15	Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9	Molecules and Cells	2015	181
16	CRISPR RNAs trigger innate immune responses in human cells	Genome Research	2018	177
17	Genome-wide target specificity of CRISPR RNA-guided adenine base editors	Nature Biotechnology	2019	151
18	Direct observation of DNA target searching and cleavage by CRISPR-Cas12a	Nature Communications	2018	148
19	Stem-piped light activates phytochrome B to trigger light responses in Arabidopsis thaliana roots	Science Signaling	2016	145
20	Genome surgery using Cas9 ribonucleoproteins for the treatment of age-related macular degeneration	Genome Research	2017	136
21	Web-based design and analysis tools for CRISPR base editing	BMC Bioinformatics	2018	127
22	Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases	Annual Review of Biochemistry	2019	120
23	The road ahead in genetics and genomics	Nature Reviews Genetics	2020	118
24	Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells	Nature Protocols	2015	113
25	Systemic Immunity Requires SnRK2.8-Mediated Nuclear Import of NPR1 in Arabidopsis	Plant Cell	2015	104
26	Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases	Cell	2022	102
27	Adenine base editors catalyze cytosine conversions in human cells	Nature Biotechnology	2019	95
28	Structural roles of guide RNAs in the nuclease activity of Cas9 endonuclease	Nature Communications	2016	94
29	Chloroplast and mitochondrial DNA editing in plants	Nature Plants	2021	91
30	CRISPR/Cas9‐mediated editing of 1‐aminocyclopropane‐1‐carboxylate oxidase1 enhances Petunia flower longevity	Plant Biotechnology Journal	2020	90
31	Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases	Nature Communications	2021	86
32	Genome editing comes of age	Nature Protocols	2016	85
33	CUT-PCR: CRISPR-mediated, ultrasensitive detection of target DNA using PCR	Oncogene	2017	84
34	Transcriptional regulatory framework for vascular cambium development in Arabidopsis roots	Nature Plants	2019	81
35	CRISPR /Cas9 searches for a protospacer adjacent motif by lateral diffusion	EMBO Journal	2019	80
36	Rescue of high-specificity Cas9 variants using sgRNAs with matched 5’ nucleotides	Genome Biology	2017	73
37	Silencing Nicotiana attenuata LHY and ZTL alters circadian rhythms in flowers	New Phytologist	2016	71
38	CRISPR-LbCpf1 prevents choroidal neovascularization in a mouse model of age-related macular degeneration	Nature Communications	2018	71
39	Precision genome engineering through adenine and cytosine base editing	Nature Plants	2018	69
40	Targeted mutagenesis in mouse cells and embryos using an enhanced prime editor	Genome Biology	2021	66
41	A simple, flexible and high‐throughput cloning system for plant genome editing via CRISPR‐Cas system	Journal of Integrative Plant Biology	2016	61
42	PE-Designer and PE-Analyzer: web-based design and analysis tools for CRISPR prime editing	Nucleic Acids Research	2021	57
43	N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis	Proceedings of the National Academy of Sciences of the United States of America	2018	56
44	Generation of cloned adult muscular pigs with myostatin gene mutation by genetic engineering	RSC Advances	2017	55
45	Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia	Science Translational Medicine	2022	52
46	dCas9-mediated Nanoelectrokinetic Direct Detection of Target Gene for Liquid Biopsy	Nano Letters	2018	50
47	Adenine base editor engineering reduces editing of bystander cytosines	Nature Biotechnology	2021	50
48	Arrayed CRISPR screen with image-based assay reliably uncovers host genes required for coxsackievirus infection	Genome Research	2018	45
49	Nuclear and mitochondrial DNA editing in human cells with zinc finger deaminases	Nature Communications	2022	43
50	Synaptotagmin 1 Negatively Controls the Two Distinct Immune Secretory Pathways to Powdery Mildew Fungi in Arabidopsis	Plant and Cell Physiology	2016	39

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