| # | Title | Journal | Year | Citations |
|---|
| 1 | Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis | New England Journal of Medicine | 2008 | 1,793 |
| 2 | Primary open-angle glaucoma | Lancet, The | 2004 | 1,728 |
| 3 | Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line | FASEB Journal | 2005 | 1,155 |
| 4 | The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis | Cell | 2009 | 914 |
| 5 | The epidemiology of age-related macular degeneration | American Journal of Ophthalmology | 2004 | 794 |
| 6 | Circuits for Local and Global Signal Integration in Primary Visual Cortex | Journal of Neuroscience | 2002 | 787 |
| 7 | Signalling to and from tight junctions | Nature Reviews Molecular Cell Biology | 2003 | 780 |
| 8 | Wnt/β-catenin signaling controls development of the blood–brain barrier | Journal of Cell Biology | 2008 | 680 |
| 9 | Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay | Lancet, The | 2001 | 666 |
| 10 | Vagaries of Visual Perception in Autism | Neuron | 2005 | 606 |
| 11 | Statin therapy and autoimmune disease: from protein prenylation to immunomodulation | Nature Reviews Immunology | 2006 | 581 |
| 12 | Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates | Nature Genetics | 2005 | 536 |
| 13 | Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function | Cell Stress and Chaperones | 1998 | 528 |
| 14 | Contrast dependence of contextual effects in primate visual cortex | Nature | 1997 | 524 |
| 15 | Unexpected low‐dose toxicity of the universal solvent DMSO | FASEB Journal | 2014 | 515 |
| 16 | A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP | EMBO Journal | 2003 | 512 |
| 17 | Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration | Nature Biotechnology | 2018 | 507 |
| 18 | Glaucoma in China: how big is the problem? | British Journal of Ophthalmology | 2001 | 497 |
| 19 | Consensus Definition for Atrophy Associated with Age-Related Macular Degeneration on OCT | Ophthalmology | 2018 | 485 |
| 20 | Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration | Nature | 2008 | 459 |
| 21 | Targeting of Golgi-Specific Pleckstrin Homology Domains Involves Both PtdIns 4-Kinase-Dependent and -Independent Components | Current Biology | 2002 | 453 |
| 22 | Distributed coding of choice, action and engagement across the mouse brain | Nature | 2019 | 452 |
| 23 | Visual pigments and oil droplets from six classes of photoreceptor in the retinas of birds | Vision Research | 1997 | 440 |
| 24 | Consensus guidelines for the use and interpretation of angiogenesis assays | Angiogenesis | 2018 | 429 |
| 25 | Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12) | Nature Genetics | 1999 | 427 |
| 26 | Consensus Nomenclature for Reporting Neovascular Age-Related Macular Degeneration Data | Ophthalmology | 2020 | 417 |
| 27 | Effective gene therapy with nonintegrating lentiviral vectors | Nature Medicine | 2006 | 416 |
| 28 | Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2 | Nature Genetics | 2005 | 388 |
| 29 | Protective Effects of Human iPS-Derived Retinal Pigment Epithelium Cell Transplantation in the Retinal Dystrophic Rat | PLoS ONE | 2009 | 382 |
| 30 | Surround Suppression in Primate V1 | Journal of Neurophysiology | 2001 | 360 |
| 31 | The ZO-1–associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density | Journal of Cell Biology | 2003 | 342 |
| 32 | Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy | Trends in Molecular Medicine | 2005 | 339 |
| 33 | Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial | Lancet, The | 2019 | 338 |
| 34 | Prevalence and Clinical Characteristics of Glaucoma in Adult Chinese: A Population-Based Study in Liwan District, Guangzhou | | 2006 | 334 |
| 35 | Risk Factors for Microbial Keratitis with Contemporary Contact Lenses | Ophthalmology | 2008 | 321 |
| 36 | Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes | Nature Reviews Molecular Cell Biology | 2019 | 318 |
| 37 | A Human Homolog of Yeast Pre-mRNA Splicing Gene, PRP31, Underlies Autosomal Dominant Retinitis Pigmentosa on Chromosome 19q13.4 (RP11) | Molecular Cell | 2001 | 305 |
| 38 | Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy | Nature Genetics | 2000 | 295 |
| 39 | The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation | Journal of Cell Science | 2002 | 295 |
| 40 | Recurrent turnover of senescent cells during regeneration of a complex structure | ELife | 2015 | 286 |
| 41 | Membrane contacts between endosomes and ER provide sites for PTP1B–epidermal growth factor receptor interaction | Nature Cell Biology | 2010 | 284 |
| 42 | Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial | Lancet, The | 2017 | 279 |
| 43 | ICAM-1-Coupled Cytoskeletal Rearrangements and Transendothelial Lymphocyte Migration Involve Intracellular Calcium Signaling in Brain Endothelial Cell Lines | Journal of Immunology | 2000 | 278 |
| 44 | Mammalian tight junctions in the regulation of epithelial differentiation and proliferation | Current Opinion in Cell Biology | 2005 | 274 |
| 45 | VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling | Nature Cell Biology | 2011 | 272 |
| 46 | Tight Junctions: Molecular Architecture and Function | International Review of Cytology | 2006 | 267 |
| 47 | Not all J domains are created equal: Implications for the specificity of Hsp40-Hsp70 interactions | Protein Science | 2005 | 265 |
| 48 | The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation | Journal of Cell Science | 2002 | 262 |
| 49 | Tight junctions and the regulation of gene expression | Biochimica Et Biophysica Acta - Biomembranes | 2009 | 261 |
| 50 | Characterizing microglia activation: a spatial statistics approach to maximize information extraction | Scientific Reports | 2017 | 261 |
