| # | Title | Journal | Year | Citations |
|---|
| 1 | Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning | Cell | 2018 | 2,822 |
| 2 | Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding | Nature Medicine | 2020 | 1,238 |
| 3 | Exosomes: biogenesis, biologic function and clinical potential | Cell and Bioscience | 2019 | 1,197 |
| 4 | In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration | Nature | 2016 | 906 |
| 5 | Severe Food Protein-Induced Enterocolitis Syndrome to Cow’s Milk in Infants | Nutrients | 2016 | 638 |
| 6 | Single-cell landscape of immunological responses in patients with COVID-19 | Nature Immunology | 2020 | 508 |
| 7 | Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence | Nature Medicine | 2019 | 386 |
| 8 | A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer | Cell Death Discovery | 2021 | 284 |
| 9 | Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition) | Annals of Translational Medicine | 2020 | 252 |
| 10 | Connections between the human gut microbiome and gestational diabetes mellitus | GigaScience | 2017 | 204 |
| 11 | Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19 | Acta Pharmaceutica Sinica B | 2020 | 193 |
| 12 | Contact Settings and Risk for Transmission in 3410 Close Contacts of Patients With COVID-19 in Guangzhou, China | Annals of Internal Medicine | 2020 | 191 |
| 13 | Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs | Proceedings of the National Academy of Sciences of the United States of America | 2020 | 174 |
| 14 | Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4 | Cardiovascular Research | 2020 | 170 |
| 15 | Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways | Cell | 2019 | 163 |
| 16 | Silver Nanoparticle Based Codelivery of Oseltamivir to Inhibit the Activity of the H1N1 Influenza Virus through ROS-Mediated Signaling Pathways | ACS Applied Materials & Interfaces | 2016 | 140 |
| 17 | METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition | Gynecologic Oncology | 2018 | 139 |
| 18 | Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups | Nature Communications | 2021 | 128 |
| 19 | Ambient Temperature and the Risk of Preterm Birth in Guangzhou, China (2001–2011) | Environmental Health Perspectives | 2016 | 124 |
| 20 | MALAT1 is a prognostic factor in glioblastoma multiforme and induces chemoresistance to temozolomide through suppressing miR-203 and promoting thymidylate synthase expression | Oncotarget | 2017 | 122 |
| 21 | Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus | International Journal of Nanomedicine | 2017 | 121 |
| 22 | Deep-learning models for the detection and incidence prediction of chronic kidney disease and type 2 diabetes from retinal fundus images | Nature Biomedical Engineering | 2021 | 121 |
| 23 | Altered Gut Microbiota in Chinese Children With Autism Spectrum Disorders | Frontiers in Cellular and Infection Microbiology | 2019 | 114 |
| 24 | Whole exome sequencing as a diagnostic adjunct to clinical testing in fetuses with structural abnormalities | Ultrasound in Obstetrics and Gynecology | 2018 | 113 |
| 25 | Noninvasive prenatal diagnosis of common aneuploidies by semiconductor sequencing | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 110 |
| 26 | Recent advances of oncolytic virus in cancer therapy | Human Vaccines and Immunotherapeutics | 2020 | 109 |
| 27 | Association of potentially functional variants in the XPG gene with neuroblastoma risk in a Chinese population | Journal of Cellular and Molecular Medicine | 2016 | 105 |
| 28 | Maternal dietary patterns and gestational diabetes mellitus: a large prospective cohort study in China | British Journal of Nutrition | 2015 | 104 |
| 29 | The Effect of Hexavalent Chromium on the Incidence and Mortality of Human Cancers: A Meta-Analysis Based on Published Epidemiological Cohort Studies | Frontiers in Oncology | 2019 | 104 |
| 30 | MiR-454-3p-Mediated Wnt/β-catenin Signaling Antagonists Suppression Promotes Breast Cancer Metastasis | Theranostics | 2019 | 103 |
| 31 | Lactose intolerance and gastrointestinal cow’s milk allergy in infants and children – common misconceptions revisited | World Allergy Organization Journal | 2017 | 101 |
| 32 | Inhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways | International Journal of Nanomedicine | 2018 | 101 |
| 33 | H3 K27M–mutant diffuse midline gliomas in different anatomical locations | Human Pathology | 2018 | 98 |
| 34 | Association of Common Genetic Variants in Pre-microRNAs and Neuroblastoma Susceptibility: A Two-Center Study in Chinese Children | Molecular Therapy - Nucleic Acids | 2018 | 98 |
| 35 | Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains | Genome Research | 2020 | 97 |
| 36 | miR-134: A Human Cancer Suppressor? | Molecular Therapy - Nucleic Acids | 2017 | 96 |
| 37 | Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129 | Molecular Neurodegeneration | 2017 | 94 |
| 38 | MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis | Cell Death and Disease | 2017 | 94 |
| 39 | Identification of candidate diagnostic and prognostic biomarkers for pancreatic carcinoma | EBioMedicine | 2019 | 93 |
| 40 | miR-200c suppresses endometriosis by targeting MALAT1 in vitro and in vivo | Stem Cell Research and Therapy | 2017 | 91 |
| 41 | PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway | Molecular Cancer | 2018 | 90 |
| 42 | Polyethylenimine-functionalized silver nanoparticle-based co-delivery of paclitaxel to induce HepG2 cell apoptosis | International Journal of Nanomedicine | 2016 | 88 |
| 43 | microRNA-96 promotes occurrence and progression of colorectal cancer via regulation of the AMPKα2-FTO-m6A/MYC axis | Journal of Experimental and Clinical Cancer Research | 2020 | 88 |
| 44 | PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway | Cell Death and Differentiation | 2022 | 88 |
| 45 | Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration | Theranostics | 2019 | 87 |
| 46 | Galactose-modified selenium nanoparticles for targeted delivery of doxorubicin to hepatocellular carcinoma | Drug Delivery | 2019 | 86 |
| 47 | Functional Polymorphisms at ERCC1/XPF Genes Confer Neuroblastoma Risk in Chinese Children | EBioMedicine | 2018 | 85 |
| 48 | Evaluation of antibody level against Fusobacterium nucleatum in the serological diagnosis of colorectal cancer | Scientific Reports | 2016 | 84 |
| 49 | Causal relationship between physical activity, leisure sedentary behaviors and COVID-19 risk: a Mendelian randomization study | Journal of Translational Medicine | 2022 | 84 |
| 50 | Platelet-derived miR-223 promotes a phenotypic switch in arterial injury repair | Journal of Clinical Investigation | 2019 | 83 |
