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Top Articles

#TitleJournalYearCitations
1The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identityNature2021187
2Chromatin Accessibility Dynamics during iPSC ReprogrammingCell Stem Cell2017180
3Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cellsNature Communications2019104
4PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCsNature Communications201787
5PCGF5 is required for neural differentiation of embryonic stem cellsNature Communications201860
6Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2Nature Communications201960
7Biomarkers of agingScience China Life Sciences202360
8Diversity among POU transcription factors in chromatin recognition and cell fate reprogrammingCellular and Molecular Life Sciences201855
9Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editingGenome Research201754
10XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear TransferStem Cell Reports201854
11MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiationNucleic Acids Research201751
12The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activityBritish Journal of Pharmacology201844
13YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation PathwaysCell Reports202044
14JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cellsNature Communications202043
15Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironmentLeukemia202038
16R-loops coordinate with SOX2 in regulating reprogramming to pluripotencyScience Advances202036
17Visualization and Quantification of Browning Using a Ucp1-2A-Luciferase Knock-in Mouse ModelDiabetes201735
18Vitamin C–dependent lysine demethylase 6 (KDM6)-mediated demethylation promotes a chromatin state that supports the endothelial-to-hematopoietic transitionJournal of Biological Chemistry201935
19CG14906 (mettl4) mediates m6A methylation of U2 snRNA in DrosophilaCell Discovery202035
20Engineering CRISPR/Cpf1 with tRNA promotes genome editing capability in mammalian systemsCellular and Molecular Life Sciences201833
21Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactionsNucleic Acids Research202030
22Automatic cell type identification methods for single-cell RNA sequencingComputational and Structural Biotechnology Journal202130
23Metabolic switch and epithelial–mesenchymal transition cooperate to regulate pluripotencyEMBO Journal202027
24Popularity and performance of bioinformatics software: the case of gene set analysisBMC Bioinformatics202126
25Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulationNature Structural and Molecular Biology202124
26Relaxed 3D genome conformation facilitates the pluripotent to totipotent-like state transition in embryonic stem cellsNucleic Acids Research202122
27CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogrammingCell Reports202222
28Characterization and generation of human definitive multipotent hematopoietic stem/progenitor cellsCell Discovery202021
29Sequential EMT-MET induces neuronal conversion through Sox2Cell Discovery201719
30Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptomsScience Advances202219
31Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylationCell Death and Differentiation202218
32Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCsCell Death and Disease201815
33YY1 safeguard multidimensional epigenetic landscape associated with extended pluripotencyNucleic Acids Research202214
34Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogrammingCell Regeneration201913
35Mitochondria as multifaceted regulators of ferroptosis202212
36The Dynamics of Metabolic Characterization in iPSC-Derived Kidney Organoid Differentiation via a Comparative Omics ApproachFrontiers in Genetics202110
37Identification of critical base pairs required for CTCF binding in motif M1 and M2Protein and Cell20179
38Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER–mitochondrial dynamicsCell Death and Disease20189
39Retrograde monosynaptic tracing through an engineered human embryonic stem cell line reveals synaptic inputs from host neurons to grafted cellsCell Regeneration20199
40Gene set analysis methods for the functional interpretation of non-mRNA data—Genomic range and ncRNA dataBriefings in Bioinformatics20209
41Single-Nucleus Chromatin Accessibility Landscape Reveals Diversity in Regulatory Regions Across Distinct Adult Rat CortexFrontiers in Molecular Neuroscience20218
42Long-chain polyunsaturated fatty acids and extensively hydrolyzed casein-induced browning in a Ucp-1 reporter mouse model of obesityFood and Function20187
43MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin looseningCell Death and Differentiation20226
44Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expressionScience China Life Sciences20226
45Chromatin Hubs: A biological and computational outlookComputational and Structural Biotechnology Journal20226
46Synergy of NUP98-HOXA10 Fusion Gene and NrasG12D Mutation Preserves the Stemness of Hematopoietic Stem Cells on Culture ConditionCells20195
47DNA Damage Induces Dynamic Associations of BRD4/P-TEFb With Chromatin and Modulates Gene Transcription in a BRD4-Dependent and -Independent MannerFrontiers in Molecular Biosciences20205
48Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane spaceScience China Life Sciences20225
49GREG—studying transcriptional regulation using integrative graph databasesDatabase: the Journal of Biological Databases and Curation20204
50AP-1 activity is a major barrier of human somatic cell reprogrammingCellular and Molecular Life Sciences20214