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Top Articles

#TitleJournalYearCitations
1Systemic Immune-Inflammation Index Predicts Prognosis of Patients after Curative Resection for Hepatocellular CarcinomaClinical Cancer Research20141,012
2Sintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): a randomised, open-label, phase 2–3 studyLancet Oncology, The2021459
3Metroticket 2.0 Model for Analysis of Competing Risks of Death After Liver Transplantation for Hepatocellular CarcinomaGastroenterology2018417
4Circulating stem cell-like epithelial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resectionHepatology2013331
5Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinomaHepatology2012298
62019 Chinese clinical guidelines for the management of hepatocellular carcinoma: updates and insightsHepatobiliary Surgery and Nutrition2020267
7N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylationNature Chemical Biology2019258
8Inducing and exploiting vulnerabilities for the treatment of liver cancerNature2019249
9IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasionJournal of Clinical Investigation2019209
10Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor SuppressionCancer Cell2014198
11Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signalingCell Death and Disease2016182
12Adjuvant Transarterial Chemoembolization for HBV-Related Hepatocellular Carcinoma After Resection: A Randomized Controlled StudyClinical Cancer Research2018181
13Long noncoding RNA HULC modulates the phosphorylation of YB‐1 through serving as a scaffold of extracellular signal–regulated kinase and YB‐1 to enhance hepatocarcinogenesisHepatology2017179
14Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathwayInternational Journal of Oncology2015177
15Circular RNA circTRIM33–12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progressionMolecular Cancer2019172
16miR‐28‐5p‐IL‐34‐macrophage feedback loop modulates hepatocellular carcinoma metastasisHepatology2016166
17Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular CarcinomaClinical Cancer Research2013159
18CXCR2/CXCL5 axis contributes to epithelial–mesenchymal transition of HCC cells through activating PI3K/Akt/GSK-3β/Snail signalingCancer Letters2015157
19CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular CarcinomaCancer Research2012150
20CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosisJournal of Hematology and Oncology2019150
21Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 InfectionCell Reports2020148
22Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axisMolecular Cancer2020147
23LncRNA SNHG3 induces EMT and sorafenib resistance by modulating the miR‐128/CD151 pathway in hepatocellular carcinomaJournal of Cellular Physiology2019143
24CXCL5 contributes to tumor metastasis and recurrence of intrahepatic cholangiocarcinoma by recruiting infiltrative intratumoral neutrophilsCarcinogenesis2014142
25Programmed cell death‐1 (PD‐1) checkpoint blockade in combination with a mammalian target of rapamycin inhibitor restrains hepatocellular carcinoma growth induced by hepatoma cell–intrinsic PD‐1Hepatology2017142
26αB-crystallin complexes with 14-3-3ζ to induce epithelial-mesenchymal transition and resistance to sorafenib in hepatocellular carcinomaHepatology2013139
27MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1Gastroenterology2019131
28Circulating Tumor Cells from Different Vascular Sites Exhibit Spatial Heterogeneity in Epithelial and Mesenchymal Composition and Distinct Clinical Significance in Hepatocellular CarcinomaClinical Cancer Research2018112
29Activating Mutations in PTPN3 Promote Cholangiocarcinoma Cell Proliferation and Migration and Are Associated With Tumor Recurrence in PatientsGastroenterology2014111
30MicroRNA-26a Inhibits Angiogenesis by Down-Regulating VEGFA through the PIK3C2α/Akt/HIF-1α Pathway in Hepatocellular CarcinomaPLoS ONE2013105
31Circulating Tumor Cells with Stem-Like Phenotypes for Diagnosis, Prognosis, and Therapeutic Response Evaluation in Hepatocellular CarcinomaClinical Cancer Research2018102
32Prognostic Significance of the Neutrophil-to-Lymphocyte Ratio in Primary Liver Cancer: A Meta-AnalysisPLoS ONE2014101
33Clinical Significance of EpCAM mRNA-Positive Circulating Tumor Cells in Hepatocellular Carcinoma by an Optimized Negative Enrichment and qRT-PCR–Based PlatformClinical Cancer Research201499
34Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formationJournal of Experimental and Clinical Cancer Research201897
35Human miR‐1228 as a stable endogenous control for the quantification of circulating microRNAs in cancer patientsInternational Journal of Cancer201493
36Ubiquitin‐specific protease 7 accelerates p14ARF degradation by deubiquitinating thyroid hormone receptor‐interacting protein 12 and promotes hepatocellular carcinoma progressionHepatology201589
37Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy for Unresectable Hepatitis B Virus-related Hepatocellular CarcinomaAnnals of Surgery202088
38Vascular endothelial cells facilitated HCC invasion and metastasis through the Akt and NF-κB pathways induced by paracrine cytokinesJournal of Experimental and Clinical Cancer Research201387
39Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate HydrataseCancer Research201685
40Current applications and future perspective of CRISPR/Cas9 gene editing in cancerMolecular Cancer202285
41The Significance of MMP-9 Over MMP-2 in HCC Invasiveness and Recurrence of Hepatocellular Carcinoma After Curative ResectionAnnals of Surgical Oncology201283
42Screening and Identifying a Novel ssDNA Aptamer against Alpha-fetoprotein Using CE-SELEXScientific Reports201583
43Heat shock proteins in hepatocellular carcinoma: Molecular mechanism and therapeutic potentialInternational Journal of Cancer201682
44Circumventing intratumoral heterogeneity to identify potential therapeutic targets in hepatocellular carcinomaJournal of Hepatology201779
45Sphere-forming culture enriches liver cancer stem cells and reveals Stearoyl-CoA desaturase 1 as a potential therapeutic targetBMC Cancer201978
46Application of the cell sheet technique in tissue engineeringBiomedical Reports201574
47Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancerJournal of Hepatology201874
48CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinomaGut202074
49Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell GrowthCell Reports202071
50Tumor-derived secretory clusterin induces epithelial–mesenchymal transition and facilitates hepatocellular carcinoma metastasisInternational Journal of Biochemistry and Cell Biology201268