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Top Articles

#TitleJournalYearCitations
1Integrated Proteogenomic Characterization of HBV-Related Hepatocellular CarcinomaCell2019629
2Targeted therapy for hepatocellular carcinomaSignal Transduction and Targeted Therapy2020320
3Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell LevelCancer Discovery2022286
4Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formationCancer Cell2021253
5PD1Hi CD8+ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinomaCancer Cell2019213
6Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular SubtypesCancer Cell2019182
7Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinomaGut2019180
8FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cellsNature2018174
9A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus StatementsLiver Cancer2020172
10Circular RNA Sequencing Identifies CircASAP1 as a Key Regulator in Hepatocellular Carcinoma MetastasisHepatology2020170
11Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axisMolecular Cancer2020147
12A Positive Feedback Loop Between Cancer Stem‐Like Cells and Tumor‐Associated Neutrophils Controls Hepatocellular Carcinoma ProgressionHepatology2019140
13International consensus statement on robotic hepatectomy surgery in 2018World Journal of Gastroenterology2019134
14MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1Gastroenterology2019131
15Heterogeneous immunogenomic features and distinct escape mechanisms in multifocal hepatocellular carcinomaJournal of Hepatology2020124
16Consensus Guidelines for the Use of Fluorescence Imaging in Hepatobiliary SurgeryAnnals of Surgery2021121
17Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinomaCancer Cell2022120
18Radiomics score: a potential prognostic imaging feature for postoperative survival of solitary HCC patientsBMC Cancer2018113
19Activated and Exhausted MAIT Cells Foster Disease Progression and Indicate Poor Outcome in Hepatocellular CarcinomaClinical Cancer Research2019109
20Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencingCell Research2018106
21Landscape of infiltrating B cells and their clinical significance in human hepatocellular carcinomaOncoImmunology201996
22Exploring prognostic indicators in the pathological images of hepatocellular carcinoma based on deep learningGut202193
23Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy for Unresectable Hepatitis B Virus-related Hepatocellular CarcinomaAnnals of Surgery202088
24Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progressionCell Discovery202084
25Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinomaNature Metabolism202377
26Bevacizumab Plus mFOLFOX6 Versus mFOLFOX6 Alone as First-Line Treatment for RAS Mutant Unresectable Colorectal Liver-Limited Metastases: The BECOME Randomized Controlled TrialJournal of Clinical Oncology202076
27Consensus recommendations of three-dimensional visualization for diagnosis and management of liver diseasesHepatology International202068
28Amplification of spatially isolated adenosine pathway by tumor–macrophage interaction induces anti-PD1 resistance in hepatocellular carcinomaJournal of Hematology and Oncology202168
29Anlotinib suppresses tumor progression via blocking the VEGFR2/PI3K/AKT cascade in intrahepatic cholangiocarcinomaCell Death and Disease202065
30Spatial and temporal clonal evolution of intrahepatic cholangiocarcinomaJournal of Hepatology201863
31Distribution and density of tertiary lymphoid structures predict clinical outcome in intrahepatic cholangiocarcinomaJournal of Hepatology202262
32Clinical practice guidelines for the treatment of primary liver cancer with integrative traditional Chinese and Western medicineJournal of Integrative Medicine201861
33Distinct PD-L1/PD1 Profiles and Clinical Implications in Intrahepatic Cholangiocarcinoma Patients with Different Risk FactorsTheranostics201961
34CircRPN2 Inhibits Aerobic Glycolysis and Metastasis in Hepatocellular CarcinomaCancer Research202257
35Cancer-associated fibroblast-derived CXCL11 modulates hepatocellular carcinoma cell migration and tumor metastasis through the circUBAP2/miR-4756/IFIT1/3 axisCell Death and Disease202156
36Tumor-associated neutrophils and macrophages interaction contributes to intrahepatic cholangiocarcinoma progression by activating STAT3Cell Death and Disease202155
37Chinese expert consensus on conversion therapy for hepatocellular carcinoma (2021 edition)Hepatobiliary Surgery and Nutrition202255
38LncRNA UCA1 promotes cisplatin resistance in gastric cancer via recruiting EZH2 and activating PI3K/AKT pathwayJournal of Cancer202053
39Spatial omics: Navigating to the golden era of cancer researchClinical and Translational Medicine202253
40PKCα/ZFP64/CSF1 axis resets the tumor microenvironment and fuels anti-PD1 resistance in hepatocellular carcinomaJournal of Hepatology202252
41Plasma hsa_circ_0027089 is a diagnostic biomarker for hepatitis B virus-related hepatocellular carcinomaCarcinogenesis202051
42Intratumoral plasmacytoid dendritic cells as a poor prognostic factor for hepatocellular carcinoma following curative resectionCancer Immunology, Immunotherapy201950
43Genomic sequencing identifies WNK2 as a driver in hepatocellular carcinoma and a risk factor for early recurrenceJournal of Hepatology201949
44Propensity Score–Matched Analysis Comparing Robotic and Laparoscopic Right and Extended Right HepatectomyJAMA Surgery202246
45Clinical significance of PD-1/PD-Ls gene amplification and overexpression in patients with hepatocellular carcinomaTheranostics201845
46Ultrasensitive and affordable assay for early detection of primary liver cancer using plasma cell‐free DNA fragmentomicsHepatology202243
47International multicentre propensity score-matched analysis comparing robotic versus laparoscopic right posterior sectionectomyBritish Journal of Surgery202142
48Splicing Regulator p54nrb/Non–POU Domain–Containing Octamer‐Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box–Dependent Interacting Protein 1 in Hepatocellular CarcinomaHepatology202040
49Single-cell transcriptomic analysis suggests two molecularly distinct subtypes of intrahepatic cholangiocarcinomaNature Communications202240
50Comparative Efficacy of Atezolizumab plus Bevacizumab and Other Treatment Options for Patients with Unresectable Hepatocellular Carcinoma: A Network Meta-AnalysisLiver Cancer202139