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Division of Chemical Biology and Medicinal Chemistry
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top-articles
Division of Chemical Biology and Medicinal Chemistry
238
(top 1%)
papers
9.7K
(top 1%)
citations
49
(top 1%)
h
-index
93
(top 1%)
g
-index
278
all documents
10.9K
doc citations
1.6K
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
ANI-1: an extensible neural network potential with DFT accuracy at force field computational cost
Chemical Science
2017
1,111
2
The promise and peril of chemical probes
Nature Chemical Biology
2015
698
3
DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility
Annual Review of Pharmacology and Toxicology
2015
539
4
An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
ACS Chemical Biology
2013
399
5
Crystal Structure of an LSD-Bound Human Serotonin Receptor
Cell
2017
340
6
Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease
Oncogene
2014
316
7
QSAR-Based Virtual Screening: Advances and Applications in Drug Discovery
Frontiers in Pharmacology
2018
291
8
Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP
Journal of Medicinal Chemistry
2013
220
9
High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain
Cell Stem Cell
2017
214
10
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
Science Signaling
2016
170
11
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
Nature Chemical Biology
2013
160
12
Curation of chemogenomics data
Nature Chemical Biology
2015
158
13
Accurate and transferable multitask prediction of chemical properties with an atoms-in-molecules neural network
Science Advances
2019
148
14
Structural basis of nucleosome-dependent cGAS inhibition
Science
2020
139
15
A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
Nature Chemical Biology
2016
133
16
Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader
Cell Chemical Biology
2020
127
17
Screening Technologies for Small Molecule Discovery: The State of the Art
Chemistry and Biology
2014
125
18
UNC2025
, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor
Journal of Medicinal Chemistry
2014
125
19
Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis
Advanced Materials
2018
125
20
Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides
Journal of the American Chemical Society
2017
119
21
Structure–Functional Selectivity Relationship Studies of β-Arrestin-Biased Dopamine D
2
Receptor Agonists
Journal of Medicinal Chemistry
2012
118
22
Chemoenzymatic Synthesis of Thiazolyl Peptide Natural Products Featuring an Enzyme-Catalyzed Formal [4 + 2] Cycloaddition
Journal of the American Chemical Society
2015
113
23
Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics
Natural Product Reports
2014
110
24
Local Blockade of Interleukin 10 and C-X-C Motif Chemokine Ligand 12 with Nano-Delivery Promotes Antitumor Response in Murine Cancers
ACS Nano
2018
101
25
Mapping allosteric communications within individual proteins
Nature Communications
2020
101
26
Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases
Nature Chemical Biology
2017
95
27
Visible Light Mediated Activation and
O-
Glycosylation of Thioglycosides
Organic Letters
2013
82
28
Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8
Journal of Medicinal Chemistry
2014
81
29
Donated chemical probes for open science
ELife
2018
80
30
Evidence for dynamics in proteins as a mechanism for ligand dissociation
Nature Chemical Biology
2012
79
31
Telomere Maintenance as a Target for Drug Discovery
Journal of Medicinal Chemistry
2014
79
32
Critical Evaluation of Human Oral Bioavailability for Pharmaceutical Drugs by Using Various Cheminformatics Approaches
Pharmaceutical Research
2014
76
33
Principles of nucleosome recognition by chromatin factors and enzymes
Current Opinion in Structural Biology
2021
73
34
Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia
ACS Medicinal Chemistry Letters
2012
67
35
Small-Molecule Ligands of Methyl-Lysine Binding Proteins: Optimization of Selectivity for L3MBTL3
Journal of Medicinal Chemistry
2013
66
36
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
Nature Communications
2018
66
37
Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors
Journal of Medicinal Chemistry
2013
64
38
The Lipid Kinase PIP5K1C Regulates Pain Signaling and Sensitization
Neuron
2014
64
39
QSAR Modeling of Tox21 Challenge Stress Response and Nuclear Receptor Signaling Toxicity Assays
Frontiers in Environmental Science
2016
63
40
P450-Mediated Non-natural Cyclopropanation of Dehydroalanine-Containing Thiopeptides
ACS Chemical Biology
2017
63
41
Supertertiary Structure of the MAGUK Core from PSD-95
Structure
2013
61
42
mRNA Delivery of a Bispecific Single‐Domain Antibody to Polarize Tumor‐Associated Macrophages and Synergize Immunotherapy against Liver Malignancies
Advanced Materials
2021
61
43
Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats
Neuroscience
2015
60
44
Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay
ACS Chemical Biology
2020
60
45
Determination of Structures and Energetics of Small- and Medium-Sized One-Carbon-Bridged Twisted Amides using ab Initio Molecular Orbital Methods: Implications for Amidic Resonance along the C–N Rotational Pathway
Journal of Organic Chemistry
2015
59
46
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3
Nature Chemical Biology
2019
59
47
Mucosal-associated invariant and γδ T cell subsets respond to initial Mycobacterium tuberculosis infection
JCI Insight
2018
59
48
UNC1062, a new and potent Mer inhibitor
European Journal of Medicinal Chemistry
2013
58
49
Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1
ACS Chemical Biology
2015
56
50
SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)
Journal of Medicinal Chemistry
2019
56
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