| # | Title | Journal | Year | Citations |
|---|
| 1 | Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer | Oncogene | 2007 | 2,421 |
| 2 | Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts | Science | 1997 | 1,505 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 4 | Extensive translation of circular RNAs driven by N6-methyladenosine | Cell Research | 2017 | 1,367 |
| 5 | Membrane-Associated Heparan Sulfate Proteoglycan Is a Receptor for Adeno-Associated Virus Type 2 Virions | Journal of Virology | 1998 | 1,263 |
| 6 | The Ras superfamily at a glance | Journal of Cell Science | 2005 | 1,222 |
| 7 | Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield | Gene Therapy | 1999 | 1,177 |
| 8 | Astrocytic Purinergic Signaling Coordinates Synaptic Networks | Science | 2005 | 1,137 |
| 9 | Splicing regulation: From a parts list of regulatory elements to an integrated splicing code | Rna | 2008 | 829 |
| 10 | Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 736 |
| 11 | Spatiotemporal dynamics of RhoA activity in migrating cells | Nature | 2006 | 734 |
| 12 | Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling | Journal of Cell Biology | 2010 | 731 |
| 13 | Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice | Gastroenterology | 1999 | 695 |
| 14 | αVβ5 integrin: a co-receptor for adeno-associated virus type 2 infection | Nature Medicine | 1999 | 665 |
| 15 | Antibiotics prevent liver injury in rats following long-term exposure to ethanol | Gastroenterology | 1995 | 659 |
| 16 | Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? | Nature Reviews Cancer | 2010 | 654 |
| 17 | DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility | Annual Review of Pharmacology and Toxicology | 2015 | 539 |
| 18 | Conditional Knock-Out of Kir4.1 Leads to Glial Membrane Depolarization, Inhibition of Potassium and Glutamate Uptake, and Enhanced Short-Term Synaptic Potentiation | Journal of Neuroscience | 2007 | 528 |
| 19 | Rho-family GTPases: it's not only Rac and Rho (and I like it) | Journal of Cell Science | 2004 | 524 |
| 20 | Inactivation of Kupffer cells prevents early alcohol-induced liver injury | Hepatology | 1994 | 508 |
| 21 | Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat | Hepatology | 1997 | 485 |
| 22 | G-protein signaling: back to the future | Cellular and Molecular Life Sciences | 2005 | 416 |
| 23 | Gender differences in the responses to noxious stimuli | Pain Forum | 1995 | 415 |
| 24 | The c-jun kinase/stress-activated pathway: Regulation, function and role in human disease | Biochimica Et Biophysica Acta - Molecular Cell Research | 2007 | 401 |
| 25 | The dark side of Ras: regulation of apoptosis | Oncogene | 2003 | 396 |
| 26 | G Protein–Coupled Receptor Sorting to Endosomes and Lysosomes | Annual Review of Pharmacology and Toxicology | 2008 | 389 |
| 27 | Hippocampal Short- and Long-Term Plasticity Are Not Modulated by Astrocyte Ca 2+ Signaling | Science | 2010 | 370 |
| 28 | The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits | International Journal of Biological Sciences | 2005 | 369 |
| 29 | Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways Is Sufficient To Cause Tumorigenic Transformation | Molecular and Cellular Biology | 1996 | 346 |
| 30 | The Ras signal transduction pathway | Cancer and Metastasis Reviews | 1994 | 342 |
| 31 | Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone | Nature | 2018 | 341 |
| 32 | Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1 | Nature | 2000 | 332 |
| 33 | Intracellular Astrocyte Calcium Waves In Situ Increase the Frequency of Spontaneous AMPA Receptor Currents in CA1 Pyramidal Neurons | Journal of Neuroscience | 2004 | 323 |
| 34 | Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease | Oncogene | 2014 | 316 |
| 35 | Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain | Pain | 1995 | 314 |
| 36 | The Nf2 Tumor Suppressor, Merlin, Functions in Rac-Dependent Signaling | Developmental Cell | 2001 | 311 |
| 37 | The F-BAR Domain of srGAP2 Induces Membrane Protrusions Required for Neuronal Migration and Morphogenesis | Cell | 2009 | 306 |
| 38 | Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer | Nature Communications | 2014 | 302 |
| 39 | The coupling of α6β4integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation | EMBO Journal | 1997 | 297 |
| 40 | Kupffer cell activation and endothelial cell damage after storage of rat livers: Effects of reperfusion | Hepatology | 1991 | 295 |
| 41 | Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism | Nature Cell Biology | 2002 | 288 |
| 42 | Ras and Rho regulation of the cell cycle and oncogenesis | Cancer Letters | 2001 | 277 |
| 43 | Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos | Science | 2003 | 277 |
| 44 | LOVTRAP: an optogenetic system for photoinduced protein dissociation | Nature Methods | 2016 | 267 |
| 45 | Structural determinants for GoLoco-induced inhibition of nucleotide release by Gα subunits | Nature | 2002 | 252 |
| 46 | Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy | Blood | 2008 | 250 |
| 47 | Oncogenic Ras and its role in tumor cell invasion and metastasis | Seminars in Cancer Biology | 2004 | 246 |
| 48 | The biochemistry of selenium and the glutathione system | Environmental Toxicology and Pharmacology | 2001 | 243 |
| 49 | The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy | Immunity | 2012 | 241 |
| 50 | Integrin-Mediated Adhesion Regulates ERK Nuclear Translocation and Phosphorylation of Elk-1 | Journal of Cell Biology | 2001 | 237 |
