# | Title | Journal | Year | Citations |
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1 | Beware of q2! | Journal of Molecular Graphics and Modelling | 2002 | 3,216 |
2 | The Importance of Being Earnest: Validation is the Absolute Essential for Successful Application and Interpretation of QSPR Models | QSAR and Combinatorial Science | 2003 | 1,698 |
3 | Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense | Toxicology and Applied Pharmacology | 2005 | 1,222 |
4 | Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells | Archives of Toxicology | 2000 | 881 |
5 | The promise and peril of chemical probes | Nature Chemical Biology | 2015 | 698 |
6 | Rational selection of training and test sets for the development of validated QSAR models | Journal of Computer-Aided Molecular Design | 2003 | 588 |
7 | microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7 | Journal of Cell Biology | 2010 | 530 |
8 | Beware of R2: Simple, Unambiguous Assessment of the Prediction Accuracy of QSAR and QSPR Models | Journal of Chemical Information and Modeling | 2015 | 495 |
9 | Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo | Gene Therapy | 2003 | 491 |
10 | Recent progress in the development of coumarin derivatives as potent anti-HIV agents | Medicinal Research Reviews | 2003 | 455 |
11 | Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation | European Journal of Pharmaceutical Sciences | 2001 | 442 |
12 | Less is more: Sampling chemical space with active learning | Journal of Chemical Physics | 2018 | 426 |
13 | Approaching coupled cluster accuracy with a general-purpose neural network potential through transfer learning | Nature Communications | 2019 | 399 |
14 | Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method | Pharmacogenetics and Genomics | 2000 | 376 |
15 | Predictive QSAR Modeling Workflow, Model Applicability Domains, and Virtual Screening | Current Pharmaceutical Design | 2007 | 369 |
16 | ZO-1 Stabilizes the Tight Junction Solute Barrier through Coupling to the Perijunctional Cytoskeleton | Molecular Biology of the Cell | 2009 | 366 |
17 | Autoimmunity is triggered by cPR-3(105–201), a protein complementary to human autoantigen proteinase-3 | Nature Medicine | 2004 | 348 |
18 | Genomewide association for schizophrenia in the CATIE study: results of stage 1 | Molecular Psychiatry | 2008 | 332 |
19 | Health Literacy: A Review | Pharmacotherapy | 2002 | 321 |
20 | Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis | Clinical Interventions in Aging | 2008 | 319 |
21 | Nanofabricated particles for engineered drug therapies: A preliminary biodistribution study of PRINT™ nanoparticles | Journal of Controlled Release | 2007 | 293 |
22 | Microscopic origins of entropy, heat capacity and the glass transition in proteins | Nature | 2001 | 292 |
23 | Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity | Drug Metabolism and Disposition | 2000 | 273 |
24 | Betulinic Acid and Dihydrobetulinic Acid Derivatives as Potent Anti-HIV Agents1 | Journal of Medicinal Chemistry | 1996 | 262 |
25 | Targeted Delivery of Antisense Oligodeoxynucleotide and Small Interference RNA into Lung Cancer Cells | Molecular Pharmaceutics | 2006 | 261 |
26 | Role of Orphan Nuclear Receptors in the Regulation of Drug-Metabolising Enzymes | Clinical Pharmacokinetics | 2003 | 248 |
27 | Antitumor Agents. 217.†Curcumin Analogues as Novel Androgen Receptor Antagonists with Potential as Anti-Prostate Cancer Agents | Journal of Medicinal Chemistry | 2002 | 243 |
28 | Relationship of Serum Digoxin Concentration to Mortality and Morbidity in Women in the Digitalis Investigation Group Trial | Journal of the American College of Cardiology | 2005 | 242 |
29 | Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study | Lancet, The | 2013 | 237 |
30 | Patient-Reported Behavior and Problems in Using Glaucoma Medications | Ophthalmology | 2006 | 229 |
31 | Integration of hepatic drug transporters and phase II metabolizing enzymes: Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites | European Journal of Pharmaceutical Sciences | 2006 | 219 |
32 | Use of Medications by Persons 65 and Over: Data From the Established Populations for Epidemiologic Studies of the Elderly | Journal of Gerontology | 1992 | 218 |
33 | Formulation and Pharmacokinetics of Self-Assembled Rifampicin Nanoparticle Systems for Pulmonary Delivery | Pharmaceutical Research | 2009 | 217 |
34 | Quantitative Structure−Activity Relationship Modeling of Rat Acute Toxicity by Oral Exposure | Chemical Research in Toxicology | 2009 | 210 |
35 | Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective | AAPS Journal | 2008 | 206 |
36 | Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity | Nature Cell Biology | 2009 | 195 |
37 | Development of an In Situ Mouse Brain Perfusion Model and its Application to mdr1a P-Glycoprotein-Deficient Mice | Journal of Cerebral Blood Flow and Metabolism | 2000 | 191 |
38 | Contrasting Measures of Adherence with Simple Drug Use, Medication Switching, and Therapeutic Duplication | Annals of Pharmacotherapy | 2009 | 191 |
39 | Vasopressin: a new target for the treatment of heart failure | American Heart Journal | 2003 | 190 |
40 | Antiparasitic compounds that target DNA | Biochimie | 2008 | 190 |
41 | Pharmacokinetic and Pharmacodynamic Implications of P-glycoprotein Modulation | Pharmacotherapy | 2001 | 189 |
42 | Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats | Drug Metabolism and Disposition | 1999 | 185 |
43 | Enhancing paracellular permeability by modulating epithelial tight junctions | Pharmaceutical Science & Technology Today | 2000 | 181 |
44 | Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes | Pharmaceutical Science & Technology Today | 2000 | 180 |
45 | Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions | Cell and Tissue Research | 2001 | 179 |
46 | ANI-1, A data set of 20 million calculated off-equilibrium conformations for organic molecules | Scientific Data | 2017 | 178 |
47 | REGULATION OF CYP2B6 IN PRIMARY HUMAN HEPATOCYTES BY PROTOTYPICAL INDUCERS | Drug Metabolism and Disposition | 2004 | 177 |
48 | Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxis | Aids | 2007 | 177 |
49 | Lopinavir/Ritonavir Induces the Hepatic Activity of Cytochrome P450 Enzymes CYP2C9, CYP2C19, and CYP1A2 But Inhibits the Hepatic and Intestinal Activity of CYP3A as Measured by a Phenotyping Drug Cocktail in Healthy Volunteers | Journal of Acquired Immune Deficiency Syndromes (1999) | 2006 | 172 |
50 | Differential Regulation of Hepatic CYP2B6 and CYP3A4 Genes by Constitutive Androstane Receptor but Not Pregnane X Receptor | Journal of Pharmacology and Experimental Therapeutics | 2006 | 171 |