| # | Title | Journal | Year | Citations |
|---|
| 1 | SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract | Cell | 2020 | 1,257 |
| 2 | Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells | Archives of Toxicology | 2000 | 881 |
| 3 | Health effects of air pollution | Journal of Allergy and Clinical Immunology | 2004 | 669 |
| 4 | Prevalence and Trends in Obesity and Severe Obesity Among Children in the United States, 1999-2012 | JAMA Pediatrics | 2014 | 624 |
| 5 | Direct Health Care Costs of Crohn's Disease and Ulcerative Colitis in US Children and Adults | Gastroenterology | 2008 | 568 |
| 6 | The Diagnosis of Bronchopulmonary Dysplasia in Very Preterm Infants. An Evidence-based Approach | American Journal of Respiratory and Critical Care Medicine | 2019 | 554 |
| 7 | The Cerebrospinal Fluid Provides a Proliferative Niche for Neural Progenitor Cells | Neuron | 2011 | 543 |
| 8 | The Cellular Metabolism and Systemic Toxicity of Arsenic | Toxicology and Applied Pharmacology | 2001 | 540 |
| 9 | Obesity is associated with impaired immune response to influenza vaccination in humans | International Journal of Obesity | 2012 | 492 |
| 10 | Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo | Gene Therapy | 2003 | 491 |
| 11 | Phenylalanine hydroxylase deficiency: diagnosis and management guideline | Genetics in Medicine | 2014 | 486 |
| 12 | Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study | Lancet, The | 2017 | 482 |
| 13 | Mouse Mutants Lacking the Type 2 IGF Receptor (IGF2R) Are Rescued from Perinatal Lethality inIgf2andIgf1rNull Backgrounds | Developmental Biology | 1996 | 444 |
| 14 | Mucopolysaccharidosis I: Management and Treatment Guidelines | Pediatrics | 2009 | 400 |
| 15 | Overview of the mucopolysaccharidoses | Rheumatology | 2011 | 384 |
| 16 | An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells | Immunity | 2011 | 383 |
| 17 | Recent Trends in the Prevalence of Crohn’s Disease and Ulcerative Colitis in a Commercially Insured US Population | Digestive Diseases and Sciences | 2013 | 382 |
| 18 | EAACI Guidelines on allergen immunotherapy: IgE‐mediated food allergy | Allergy: European Journal of Allergy and Clinical Immunology | 2018 | 379 |
| 19 | Insulin-Like Growth Factor-I Promotes Neurogenesis and Synaptogenesis in the Hippocampal Dentate Gyrus during Postnatal Development | Journal of Neuroscience | 2000 | 317 |
| 20 | Allergen immunotherapy for IgE‐mediated food allergy: a systematic review and meta‐analysis | Allergy: European Journal of Allergy and Clinical Immunology | 2017 | 315 |
| 21 | Which Comes First in Adolescence—Sex and Drugs or Depression? | American Journal of Preventive Medicine | 2005 | 303 |
| 22 | Selenium Deficiency and Viral Infection | Journal of Nutrition | 2003 | 302 |
| 23 | A Novel S-Adenosyl-l-methionine:Arsenic(III) Methyltransferase from Rat Liver Cytosol | Journal of Biological Chemistry | 2002 | 299 |
| 24 | Mycoplasma pneumoniae Disease: Clinical Spectrum, Pathophysiology, Epidemiology, and Control | Journal of Infectious Diseases | 1971 | 281 |
| 25 | The Relationship between Glaucoma Medication Adherence, Eye Drop Technique, and Visual Field Defect Severity | Ophthalmology | 2011 | 270 |
| 26 | The Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Hydrolyzed Formulas, and Timing of Introduction of Allergenic Complementary Foods | Pediatrics | 2019 | 270 |
| 27 | E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion | American Journal of Respiratory and Critical Care Medicine | 2018 | 263 |
| 28 | Elucidating the pathway for arsenic methylation*1 | Toxicology and Applied Pharmacology | 2004 | 262 |
| 29 | Adolescent depression and suicide riskAssociation with sex and drug behavior | American Journal of Preventive Medicine | 2004 | 261 |
| 30 | Risk Factors for Chronic Lung Disease in the Surfactant Era: A North Carolina Population-based Study of Very Low Birth Weight Infants | Pediatrics | 1999 | 248 |
| 31 | Thromboembolic risk among Danish children and adults with inflammatory bowel diseases: a population-based nationwide study | Gut | 2011 | 238 |
| 32 | Fetal Growth Restriction and Chronic Lung Disease Among Infants Born Before the 28th Week of Gestation | Pediatrics | 2009 | 236 |
| 33 | Nasal and Bronchoalveolar Lavage Fluid Cytokines in Early Cystic Fibrosis | Journal of Infectious Diseases | 1997 | 235 |
| 34 | The genomic landscape of juvenile myelomonocytic leukemia | Nature Genetics | 2015 | 233 |
| 35 | Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease | Blood | 2005 | 227 |
| 36 | Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells. | Molecular Biology of the Cell | 1994 | 218 |
| 37 | Determination of Trivalent Methylated Arsenicals in Biological Matrices | Toxicology and Applied Pharmacology | 2001 | 217 |
| 38 | Tetralogy of Fallot | Orphanet Journal of Rare Diseases | 2009 | 216 |
| 39 | Risk of Cancer in Patients With Inflammatory Bowel Diseases: A Nationwide Population-based Cohort Study With 30 Years of Follow-up Evaluation | Clinical Gastroenterology and Hepatology | 2014 | 205 |
| 40 | Dietary Patterns and Self-Reported Associations of Diet with Symptoms of Inflammatory Bowel Disease | Digestive Diseases and Sciences | 2013 | 204 |
| 41 | Androgen receptor expression in androgen-independent prostate cancer is associated with increased expression of androgen-regulated genes | Cancer Research | 1998 | 204 |
| 42 | Myelination Is Altered in Insulin-Like Growth Factor-I Null Mutant Mice | Journal of Neuroscience | 2002 | 203 |
| 43 | Increased risk of influenza among vaccinated adults who are obese | International Journal of Obesity | 2017 | 200 |
| 44 | Mutant mouse models of insulin-like growth factor actions in the central nervous system | Neuropeptides | 2002 | 198 |
| 45 | Mutation Analysis of Core Binding Factor A1 in Patients with Cleidocranial Dysplasia | American Journal of Human Genetics | 1999 | 193 |
| 46 | Motile ciliopathies | Nature Reviews Disease Primers | 2020 | 191 |
| 47 | Long-term, open-labeled extension study of idursulfase in the treatment of Hunter syndrome | Genetics in Medicine | 2011 | 190 |
| 48 | Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure | CNS Neuroscience and Therapeutics | 2019 | 186 |
| 49 | Inflammatory bowel diseases in pediatric and adolescent patients: Clinical, therapeutic, and psychosocial considerations | Gastroenterology | 2004 | 183 |
| 50 | ZMYND10 Is Mutated in Primary Ciliary Dyskinesia and Interacts with LRRC6 | American Journal of Human Genetics | 2013 | 183 |
