| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Reconstituting Organ-Level Lung Functions on a Chip | Science | 2010 | 3,349 |
| 2 | Microfluidic organs-on-chips | Nature Biotechnology | 2014 | 2,578 |
| 3 | A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice | Science Translational Medicine | 2012 | 831 |
| 4 | Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment | Integrative Biology (United Kingdom) | 2013 | 680 |
| 5 | Substrate stress relaxation regulates cell spreading | Nature Communications | 2015 | 677 |
| 6 | Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels | Advanced Functional Materials | 2012 | 647 |
| 7 | Engineered In Vitro Disease Models | Annual Review of Pathology: Mechanisms of Disease | 2015 | 459 |
| 8 | Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro | Nature Methods | 2014 | 387 |
| 9 | Paper-supported 3D cell culture for tissue-based bioassays | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 384 |
| 10 | Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip | PLoS ONE | 2016 | 352 |
| 11 | Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro | Cell Reports | 2017 | 339 |
| 12 | Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage | ACS Nano | 2014 | 336 |
| 13 | Reproducing human and cross-species drug toxicities using a Liver-Chip | Science Translational Medicine | 2019 | 322 |
| 14 | TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling | Circulation Research | 2009 | 317 |
| 15 | Soft robotic sleeve supports heart function | Science Translational Medicine | 2017 | 310 |
| 16 | Engineering a highly elastic human protein–based sealant for surgical applications | Science Translational Medicine | 2017 | 278 |
| 17 | Primary Human Lung Alveolus‐on‐a‐chip Model of Intravascular Thrombosis for Assessment of Therapeutics | Clinical Pharmacology and Therapeutics | 2018 | 258 |
| 18 | Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip | Cell Systems | 2016 | 243 |
| 19 | Highly Elastic and Conductive Human‐Based Protein Hybrid Hydrogels | Advanced Materials | 2016 | 236 |
| 20 | Influence of the stiffness of three-dimensional alginate/collagen-I interpenetrating networks on fibroblast biology | Biomaterials | 2014 | 235 |
| 21 | Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins | Integrative Biology (United Kingdom) | 2010 | 229 |
| 22 | Mechanotransduction of fluid stresses governs 3D cell migration | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 226 |
| 23 | A Highly Elastic and Rapidly Crosslinkable Elastin‐Like Polypeptide‐Based Hydrogel for Biomedical Applications | Advanced Functional Materials | 2015 | 213 |
| 24 | Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities | Lab on A Chip | 2017 | 202 |
| 25 | A highly adhesive and naturally derived sealant | Biomaterials | 2017 | 201 |
| 26 | Stability of Surface-Immobilized Lubricant Interfaces under Flow | Chemistry of Materials | 2015 | 187 |
| 27 | Cell Surface Engineering with Polyelectrolyte Multilayer Thin Films | Journal of the American Chemical Society | 2011 | 182 |
| 28 | Reverse Engineering Human Pathophysiology with Organs-on-Chips | Cell | 2016 | 181 |
| 29 | Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies? | Advanced Science | 2020 | 176 |
| 30 | Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology | Cellular and Molecular Gastroenterology and Hepatology | 2020 | 163 |
| 31 | Nanoengineered biomimetic hydrogels for guiding human stem cell osteogenesis in three dimensional microenvironments | Journal of Materials Chemistry B | 2016 | 154 |
| 32 | Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion | Journal of Experimental Medicine | 2010 | 149 |
| 33 | Collagen and Elastin Biomaterials for the Fabrication of Engineered Living Tissues | ACS Biomaterials Science and Engineering | 2017 | 147 |
| 34 | Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips | Annual Review of Pharmacology and Toxicology | 2018 | 141 |
| 35 | Click‐Crosslinked Injectable Gelatin Hydrogels | Advanced Healthcare Materials | 2016 | 135 |
| 36 | Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip | IScience | 2019 | 134 |
| 37 | Tri-layered elastomeric scaffolds for engineering heart valve leaflets | Biomaterials | 2014 | 132 |
| 38 | A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells | Scientific Reports | 2014 | 126 |
| 39 | Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy | Lab on A Chip | 2019 | 117 |
| 40 | Strain Response of the Anterior Cruciate Ligament to Uniplanar and Multiplanar Loads During Simulated Landings | American Journal of Sports Medicine | 2016 | 107 |
| 41 | Inhibition of Mammary Tumor Growth Using Lysyl Oxidase-Targeting Nanoparticles to Modify Extracellular Matrix | Nano Letters | 2012 | 103 |
| 42 | Unexpected Strength and Toughness in Chitosan‐Fibroin Laminates Inspired by Insect Cuticle | Advanced Materials | 2012 | 102 |
| 43 | Manufacturing of Large‐Scale Functional Objects Using Biodegradable Chitosan Bioplastic | Macromolecular Materials and Engineering | 2014 | 102 |
| 44 | Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells | FASEB Journal | 2010 | 99 |
| 45 | Nogo-A is a negative regulator of CNS angiogenesis | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 97 |
| 46 | JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement | Biomaterials | 2017 | 97 |
| 47 | Synthetic niche to modulate regenerative potential of MSCs and enhance skeletal muscle regeneration | Biomaterials | 2016 | 90 |
| 48 | The blood compatibility challenge. Part 4: Surface modification for hemocompatible materials: Passive and active approaches to guide blood-material interactions | Acta Biomaterialia | 2019 | 89 |
| 49 | Human Organs-on-Chips for Virology | Trends in Microbiology | 2020 | 86 |
| 50 | Breakthrough treatments for accelerated wound healing | Science Advances | 2023 | 84 |
