Harvard Medical School

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Top Articles

#	Title	Journal	Year	Citations
1	Toehold Switches: De-Novo-Designed Regulators of Gene Expression	Cell	2014	646
2	Engineering cyanobacteria to generate high-value products	Trends in Biotechnology	2011	443
3	Quantitative super-resolution imaging with qPAINT	Nature Methods	2016	328
4	Complex cellular logic computation using ribocomputing devices	Nature	2017	321
5	Polyhedra Self-Assembled from DNA Tripods and Characterized with 3D DNA-PAINT	Science	2014	299
6	Rerouting Carbon Flux To Enhance Photosynthetic Productivity	Applied and Environmental Microbiology	2012	298
7	SABER amplifies FISH: enhanced multiplexed imaging of RNA and DNA in cells and tissues	Nature Methods	2019	271
8	Casting inorganic structures with DNA molds	Science	2014	251
9	Engineering Cyanobacteria To Synthesize and Export Hydrophilic Products	Applied and Environmental Microbiology	2010	222
10	Optical imaging of individual biomolecules in densely packed clusters	Nature Nanotechnology	2016	204
11	The emerging landscape of single-molecule protein sequencing technologies	Nature Methods	2021	198
12	DNA-barcoded labeling probes for highly multiplexed Exchange-PAINT imaging	Chemical Science	2017	172
13	OligoMiner provides a rapid, flexible environment for the design of genome-scale oligonucleotide in situ hybridization probes	Proceedings of the National Academy of Sciences of the United States of America	2018	168
14	In vivoco-localization of enzymes on RNA scaffolds increases metabolic production in a geometrically dependent manner	Nucleic Acids Research	2014	143
15	Reconfigurable Three-Dimensional Gold Nanorod Plasmonic Nanostructures Organized on DNA Origami Tripod	ACS Nano	2017	129
16	The Bacterial Carbon-Fixing Organelle Is Formed by Shell Envelopment of Preassembled Cargo	PLoS ONE	2013	114
17	Nanoscale Growth and Patterning of Inorganic Oxides Using DNA Nanostructure Templates	Journal of the American Chemical Society	2013	97
18	Developmental Self-Assembly of a DNA Tetrahedron	ACS Nano	2014	97
19	Precise pitch-scaling of carbon nanotube arrays within three-dimensional DNA nanotrenches	Science	2020	97
20	Large protein organelles form a new iron sequestration system with high storage capacity	ELife	2019	92
21	Encapsulins: microbial nanocompartments with applications in biomedicine, nanobiotechnology and materials science	Current Opinion in Chemical Biology	2016	85
22	124-Color Super-resolution Imaging by Engineering DNA-PAINT Blinking Kinetics	Nano Letters	2019	82
23	Creating Single-Copy Genetic Circuits	Molecular Cell	2016	62
24	Valorization of CO2 through lithoautotrophic production of sustainable chemicals in Cupriavidus necator	Metabolic Engineering	2020	60
25	Sub–100-nm metafluorophores with digitally tunable optical properties self-assembled from DNA	Science Advances	2017	58
26	Designing and using RNA scaffolds to assemble proteins in vivo	Nature Protocols	2012	57
27	Large-scale recoding of a bacterial genome by iterative recombineering of synthetic DNA	Nucleic Acids Research	2017	54
28	The case for biotech on Mars	Nature Biotechnology	2020	53
29	Building Spatial Synthetic Biology with Compartments, Scaffolds, and Communities	Cold Spring Harbor Perspectives in Biology	2016	46
30	Enhancing Biocompatible Stability of DNA Nanostructures Using Dendritic Oligonucleotides and Brick Motifs	Angewandte Chemie - International Edition	2020	46
31	Engineering carbon fixation with artificial protein organelles	Current Opinion in Biotechnology	2017	45
32	DNA Nanostructures-Mediated Molecular Imprinting Lithography	ACS Nano	2017	43
33	Adjuvant‐Loaded Subcellular Vesicles Derived From Disrupted Cancer Cells for Cancer Vaccination	Small	2016	39
34	Engineered Interspecies Amino Acid Cross-Feeding Increases Population Evenness in a Synthetic Bacterial Consortium	MSystems	2019	39
35	Programmably Shaped Carbon Nanostructure from Shape-Conserving Carbonization of DNA	ACS Nano	2016	37
36	Stable Neutralization of a Virulence Factor in Bacteria Using Temperate Phage in the Mammalian Gut	MSystems	2020	36
37	Synthetic Gene Circuits Enable Systems-Level Biosensor Trigger Discovery at the Host-Microbe Interface	MSystems	2019	32
38	Ribocomputing: Cellular Logic Computation Using RNA Devices	Biochemistry	2018	29
39	Light-Seq: light-directed in situ barcoding of biomolecules in fixed cells and tissues for spatially indexed sequencing	Nature Methods	2022	27
40	An objective function exploiting suboptimal solutions in metabolic networks	BMC Systems Biology	2013	23
41	Super‐resolution Geometric Barcoding for Multiplexed miRNA Profiling	Angewandte Chemie - International Edition	2018	23
42	Complex Reconfiguration of DNA Nanostructures	Angewandte Chemie - International Edition	2014	21
43	Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly	Nature Methods	2022	21
44	Nanoscale imaging in DNA nanotechnology	Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology	2012	20
45	Super-resolution labelling with Action-PAINT	Nature Chemistry	2019	20
46	Engineering acyl carrier protein to enhance production of shortened fatty acids	Biotechnology for Biofuels	2016	19
47	A Tunable Protein Piston That Breaks Membranes to Release Encapsulated Cargo	ACS Synthetic Biology	2016	19
48	Efficient size-independent chromosome delivery from yeast to cultured cell lines	Nucleic Acids Research	2017	18
49	DyNAMiC Workbench: an integrated development environment for dynamic DNA nanotechnology	Journal of the Royal Society Interface	2015	17
50	Targeted erythropoietin selectively stimulates red blood cell expansion in vivo	Proceedings of the National Academy of Sciences of the United States of America	2016	16

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