| Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation | Cell Metabolism | 2016 | 581 |
| TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes | New England Journal of Medicine | 2016 | 493 |
| Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults | Nature Communications | 2016 | 346 |
| Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 286 |
| Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences | Trends in Biochemical Sciences | 2016 | 280 |
| Hypophosphatasia - aetiology, nosology, pathogenesis, diagnosis and treatment | Nature Reviews Endocrinology | 2016 | 247 |
| Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression | Cancer Cell | 2016 | 145 |
| Antibiotics promote inflammation through the translocation of native commensal colonic bacteria | Gut | 2016 | 141 |
| Correcting mitochondrial fusion by manipulating mitofusin conformations | Nature | 2016 | 136 |
| Cardiac Mechano-Gated Ion Channels and Arrhythmias | Circulation Research | 2016 | 113 |
| Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction | Cell Death and Disease | 2016 | 102 |
| Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms | ELife | 2016 | 100 |
| Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery | Cell Reports | 2016 | 82 |
| INTEGRATE: gene fusion discovery using whole genome and transcriptome data | Genome Research | 2016 | 81 |
| Data publication with the structural biology data grid supports live analysis | Nature Communications | 2016 | 78 |
| Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts | Behavior Genetics | 2016 | 77 |
| A Phase I Trial of BKM120 (Buparlisib) in Combination with Fulvestrant in Postmenopausal Women with Estrogen Receptor-Positive Metastatic Breast Cancer | Clinical Cancer Research | 2016 | 77 |
| Development of a bile acid-based newborn screen for Niemann-Pick disease type C | Science Translational Medicine | 2016 | 75 |
| American Clinical Neurophysiology Society Guideline 2: Guidelines for Standard Electrode Position Nomenclature | Journal of Clinical Neurophysiology | 2016 | 70 |
| Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis | Cell Host and Microbe | 2016 | 66 |
| A Case-Control Study Assessing the Impact of Nonventilated Hospital-Acquired Pneumonia on Patient Outcomes | Chest | 2016 | 66 |
| Phase II study of MLN8237 (Alisertib) in advanced/metastatic sarcoma | Annals of Oncology | 2016 | 61 |
| Evolution of the complement system: from defense of the single cell to guardian of the intravascular space | Immunological Reviews | 2016 | 60 |
| Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VII | Molecular Therapy | 2016 | 56 |
| A Phase I Study of the AKT Inhibitor MK-2206 in Combination with Hormonal Therapy in Postmenopausal Women with Estrogen Receptor-Positive Metastatic Breast Cancer | Clinical Cancer Research | 2016 | 54 |
