| # | Title | Journal | Year | Citations |
|---|
| 1 | Lateral gene transfer and the nature of bacterial innovation | Nature | 2000 | 3,303 |
| 2 | Flavivirus Genome Organization, Expression, and Replication | Annual Review of Microbiology | 1990 | 1,829 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 4 | A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells | Nature | 2008 | 1,341 |
| 5 | The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens | Science | 2012 | 1,314 |
| 6 | Efficient Initiation of HCV RNA Replication in Cell Culture | Science | 2000 | 1,312 |
| 7 | Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase | Nature | 2000 | 1,251 |
| 8 | The Genome of the Kinetoplastid Parasite, Leishmania major | Science | 2005 | 1,237 |
| 9 | Toxoplasma gondii Comprises Three Clonal Lineages: Correlation of Parasite Genotype with Human Disease | Journal of Infectious Diseases | 1995 | 1,186 |
| 10 | Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens | Science | 1993 | 1,140 |
| 11 | Intracellular Bacterial Biofilm-Like Pods in Urinary Tract Infections | Science | 2003 | 976 |
| 12 | Heat shock proteins. | Journal of Biological Chemistry | 1990 | 953 |
| 13 | Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition | Cell Host and Microbe | 2021 | 937 |
| 14 | Redefining Chronic Viral Infection | Cell | 2009 | 876 |
| 15 | Expression and identification of hepatitis C virus polyprotein cleavage products | Journal of Virology | 1993 | 860 |
| 16 | Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages | Nature Immunology | 2014 | 856 |
| 17 | Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies | Nature Medicine | 2021 | 838 |
| 18 | TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes | Science Immunology | 2020 | 811 |
| 19 | Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation | Science | 2002 | 802 |
| 20 | Mg2+ as an Extracellular Signal: Environmental Regulation of Salmonella Virulence | Cell | 1996 | 793 |
| 21 | N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 | Cell | 2021 | 784 |
| 22 | The Pleiotropic Two-Component Regulatory System PhoP-PhoQ | Journal of Bacteriology | 2001 | 777 |
| 23 | DNA diversity among clinical isolates ofHelicobacter pyloridetected by PCR-based RAPD fingerprinting | Nucleic Acids Research | 1992 | 776 |
| 24 | STAT1-Dependent Innate Immunity to a Norwalk-Like Virus | Science | 2003 | 757 |
| 25 | TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease | Cell | 2017 | 741 |
| 26 | Heat shock proteins | Journal of Biological Chemistry | 1990 | 738 |
| 27 | 2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members | Nature | 2010 | 736 |
| 28 | Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide | Cell | 1996 | 735 |
| 29 | X–linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein | Nature Genetics | 1996 | 691 |
| 30 | Transmission of Hepatitis C by Intrahepatic Inoculation with Transcribed RNA | Science | 1997 | 670 |
| 31 | The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans | Science | 2005 | 664 |
| 32 | Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites | Journal of Virology | 1993 | 617 |
| 33 | Role of Nonhost Environments in the Lifestyles of Salmonella and Escherichia coli | Applied and Environmental Microbiology | 2003 | 611 |
| 34 | Phagocytic processing of bacterial antigens for class I MHC presentation to T cells | Nature | 1993 | 605 |
| 35 | Toxoplasma Invasion of Mammalian Cells Is Powered by the Actin Cytoskeleton of the Parasite | Cell | 1996 | 590 |
| 36 | Analyses of the cag pathogenicity island of Helicobacter pylori | Molecular Microbiology | 2002 | 583 |
| 37 | X-ray Structure of the FimC-FimH Chaperone-Adhesin Complex from Uropathogenic Escherichia coli | Science | 1999 | 582 |
| 38 | Identification of a Novel Polyomavirus from Patients with Acute Respiratory Tract Infections | PLoS Pathogens | 2007 | 581 |
| 39 | Hepatitis C Virus-Encoded Enzymatic Activities and Conserved RNA Elements in the 3′ Nontranslated Region Are Essential for Virus Replication In Vivo | Journal of Virology | 2000 | 571 |
| 40 | Polymorphic Secreted Kinases Are Key Virulence Factors in Toxoplasmosis | Science | 2006 | 563 |
| 41 | Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 551 |
| 42 | Lactobacillus reuteri induces gut intraepithelial CD4 + CD8αα + T cells | Science | 2017 | 543 |
| 43 | Pathogenicity Islands: Bacterial Evolution in Quantum Leaps | Cell | 1996 | 528 |
| 44 | Morphological plasticity as a bacterial survival strategy | Nature Reviews Microbiology | 2008 | 525 |
| 45 | Early life dynamics of the human gut virome and bacterial microbiome in infants | Nature Medicine | 2015 | 523 |
| 46 | Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts | European Journal of Cell Biology | 1997 | 522 |
| 47 | Bacterial Adhesins in Host-Microbe Interactions | Cell Host and Microbe | 2009 | 521 |
| 48 | A Secreted Serine-Threonine Kinase Determines Virulence in the Eukaryotic Pathogen Toxoplasma gondii | Science | 2006 | 520 |
| 49 | The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy | Cell Host and Microbe | 2015 | 520 |
| 50 | Cellular cofactors affecting hepatitis C virus infection and replication | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 511 |
