| # | Title | Journal | Year | Citations |
|---|
| 1 | Measurement of Prostate-Specific Antigen in Serum as a Screening Test for Prostate Cancer | New England Journal of Medicine | 1991 | 2,106 |
| 2 | Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma | Thyroid | 2015 | 1,738 |
| 3 | Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens | Nature | 2014 | 1,705 |
| 4 | Laparoscopic Nephrectomy: Initial Case Report | Journal of Urology | 1991 | 1,483 |
| 5 | The Effectiveness and Risks of Bariatric Surgery | JAMA Surgery | 2014 | 1,336 |
| 6 | Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma | Journal of Immunology | 2002 | 1,326 |
| 7 | Diagnosis and Management of Complicated Intra-abdominal Infection in Adults and Children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America | Clinical Infectious Diseases | 2010 | 1,260 |
| 8 | Medullary Thyroid Cancer: Management Guidelines of the American Thyroid Association | Thyroid | 2009 | 1,247 |
| 9 | TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth | Cell | 2006 | 1,183 |
| 10 | The surgical treatment of atrial fibrillation | Journal of Thoracic and Cardiovascular Surgery | 1991 | 1,141 |
| 11 | An analysis of the problem of biliary injury during laparoscopic cholecystectomy | Journal of the American College of Surgeons | 1995 | 1,035 |
| 12 | A Prospectively Validated Clinical Risk Score Accurately Predicts Pancreatic Fistula after Pancreatoduodenectomy | Journal of the American College of Surgeons | 2013 | 912 |
| 13 | Hazards of postoperative atrial arrhythmias | Annals of Thoracic Surgery | 1993 | 902 |
| 14 | Bilateral pneumectomy (volume reduction) for chronic obstructive pulmonary disease | Journal of Thoracic and Cardiovascular Surgery | 1995 | 882 |
| 15 | Pretreatment Assessment of Resectable and Borderline Resectable Pancreatic Cancer: Expert Consensus Statement | Annals of Surgical Oncology | 2009 | 821 |
| 16 | Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses | Cancer Research | 2013 | 797 |
| 17 | A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome | Cell Reports | 2016 | 745 |
| 18 | Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms | Journal of Clinical Investigation | 2000 | 739 |
| 19 | Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy | Nature Medicine | 2016 | 738 |
| 20 | Nomenclature of hepatic anatomy and resections: a review of the Brisbane 2000 system | Journal of Hepato-Biliary-Pancreatic Surgery | 2005 | 726 |
| 21 | A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome) | Nature Genetics | 1998 | 654 |
| 22 | POTENCY, CONTINENCE AND COMPLICATION RATES IN 1,870 CONSECUTIVE RADICAL RETROPUBIC PROSTATECTOMIES | Journal of Urology | 1999 | 652 |
| 23 | Obesity and Cancer | Oncologist | 2010 | 628 |
| 24 | Human body epigenome maps reveal noncanonical DNA methylation variation | Nature | 2015 | 605 |
| 25 | Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B. | Proceedings of the National Academy of Sciences of the United States of America | 1994 | 564 |
| 26 | Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial | Lancet Oncology, The | 2016 | 557 |
| 27 | Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets | Nature Immunology | 2015 | 551 |
| 28 | Five-Year Survival After Resection of Hepatic Metastases From Colorectal Cancer in Patients Screened by Positron Emission Tomography With F-18 Fluorodeoxyglucose (FDG-PET) | Annals of Surgery | 2004 | 541 |
| 29 | Initial Management of Burns | New England Journal of Medicine | 1996 | 519 |
| 30 | Physical activity and colon cancer prevention: a meta-analysis | British Journal of Cancer | 2009 | 518 |
| 31 | Genetic markers in sepsis | Journal of the American College of Surgeons | 2001 | 516 |
| 32 | Selecting the donor liver: Risk factors for poor function after orthotopic liver transplantation | Hepatology | 1994 | 514 |
| 33 | The surgical treatment of atrial fibrillation | Journal of Thoracic and Cardiovascular Surgery | 1991 | 482 |
| 34 | Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease | Nature Medicine | 2008 | 477 |
| 35 | Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis | Clinical Cancer Research | 2013 | 473 |
| 36 | Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer | Breast Cancer Research and Treatment | 2014 | 472 |
| 37 | Robot Assisted Partial Nephrectomy Versus Laparoscopic Partial Nephrectomy for Renal Tumors: A Multi-Institutional Analysis of Perioperative Outcomes | Journal of Urology | 2009 | 468 |
| 38 | Five-year experience with the maze procedure for atrial fibrillation | Annals of Thoracic Surgery | 1993 | 464 |
| 39 | Guidelines for the Selection of Anti-infective Agents for Complicated Intra-abdominal Infections | Clinical Infectious Diseases | 2003 | 464 |
| 40 | Modification of the maze procedure for atrial flutter and atrial fibrillation | Journal of Thoracic and Cardiovascular Surgery | 1995 | 461 |
| 41 | Effect of Steatohepatitis Associated with Irinotecan or Oxaliplatin Pretreatment on Resectability of Hepatic Colorectal Metastases | Journal of the American College of Surgeons | 2005 | 450 |
| 42 | Determinants of metastatic rate and survival in patients with zollinger-ellison syndrome: A prospective long-term study | Gastroenterology | 1995 | 443 |
| 43 | A Meta-analysis of Prospective Trials Comparing Percutaneous and Surgical Tracheostomy in Critically Ill Patients | Chest | 2000 | 441 |
| 44 | The human heart contains distinct macrophage subsets with divergent origins and functions | Nature Medicine | 2018 | 439 |
| 45 | Prostate Cancer Detection in Men With Serum PSA Concentrations of 2.6 to 4.0 ng/mL and Benign Prostate Examination | JAMA - Journal of the American Medical Association | 1997 | 429 |
| 46 | Evaluation of Percentage of Free Serum Prostate-Specific Antigen to Improve Specificity of Prostate Cancer Screening | JAMA - Journal of the American Medical Association | 1995 | 427 |
| 47 | Laparoscopic Cholecystectomy The New 'Gold Standard'? | Archives of Surgery | 1992 | 417 |
| 48 | Modification of the maze procedure for atrial flutter and atrial fibrillation | Journal of Thoracic and Cardiovascular Surgery | 1995 | 416 |
| 49 | Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages. | Journal of Clinical Investigation | 1995 | 416 |
| 50 | Obesity Epidemiology Worldwide | Gastroenterology Clinics of North America | 2016 | 404 |
