| # | Title | Journal | Year | Citations |
|---|
| 1 | The Influence of Inadequate Antimicrobial Treatment of Bloodstream Infections on Patient Outcomes in the ICU Setting | Chest | 2000 | 1,641 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 3 | Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation | Critical Care Medicine | 1999 | 1,040 |
| 4 | Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials | Lancet Respiratory Medicine,the | 2015 | 937 |
| 5 | SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function | Nature Immunology | 2020 | 743 |
| 6 | The Epidemiology, Pathogenesis and Treatment of Pseudomonas aeruginosa Infections | Drugs | 2007 | 710 |
| 7 | Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells | Journal of Experimental Medicine | 2010 | 662 |
| 8 | Experience with a clinical guideline for the treatment of ventilator-associated pneumonia | Critical Care Medicine | 2001 | 536 |
| 9 | A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2 | Cell | 2020 | 446 |
| 10 | Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth Official Adult Lung and Heart–Lung Transplantation Report—2007 | Journal of Heart and Lung Transplantation | 2007 | 436 |
| 11 | The Importance of Fluid Management in Acute Lung Injury Secondary to Septic Shock | Chest | 2009 | 436 |
| 12 | Respiratory Viral Infections Are a Distinct Risk for Bronchiolitis Obliterans Syndrome and Death | American Journal of Respiratory and Critical Care Medicine | 2004 | 296 |
| 13 | The complement system in COVID-19: friend and foe? | JCI Insight | 2020 | 295 |
| 14 | Early versus late enteral feeding of mechanically ventilated patients: results of a clinical trial | Journal of Parenteral and Enteral Nutrition | 2002 | 280 |
| 15 | Airway Remodeling Measured by Multidetector CT Is Increased in Severe Asthma and Correlates With Pathology | Chest | 2008 | 260 |
| 16 | A Multivariate Analysis of Risk Factors for the Air-Trapping Asthmatic Phenotype as Measured by Quantitative CT Analysis | Chest | 2009 | 260 |
| 17 | Cutting Edge: Murine UL16-Binding Protein-Like Transcript 1: A Newly Described Transcript Encoding a High-Affinity Ligand for Murine NKG2D | Journal of Immunology | 2002 | 257 |
| 18 | Interleukin-17 Is Required for T Helper 1 Cell Immunity and Host Resistance to the Intracellular Pathogen Francisella tularensis | Immunity | 2009 | 255 |
| 19 | Cefiderocol versus high-dose, extended-infusion meropenem for the treatment of Gram-negative nosocomial pneumonia (APEKS-NP): a randomised, double-blind, phase 3, non-inferiority trial | Lancet Infectious Diseases, The | 2021 | 255 |
| 20 | Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study | Critical Care | 2014 | 247 |
| 21 | Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data | Journal of Allergy and Clinical Immunology | 2014 | 247 |
| 22 | Predictors of 30-Day Mortality and Hospital Costs in Patients With Ventilator-Associated Pneumonia Attributed to Potentially Antibiotic-Resistant Gram-Negative Bacteria | Chest | 2008 | 238 |
| 23 | Guidelines for Genome-Scale Analysis of Biological Rhythms | Journal of Biological Rhythms | 2017 | 237 |
| 24 | Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment | Journal of Allergy and Clinical Immunology | 2017 | 222 |
| 25 | Anti-human leukocyte antigen antibodies and preemptive antibody-directed therapy after lung transplantation | Journal of Heart and Lung Transplantation | 2010 | 212 |
| 26 | An international multicenter retrospective study of Pseudomonas aeruginosa nosocomial pneumonia: impact of multidrug resistance | Critical Care | 2015 | 209 |
| 27 | Interventional and surgical modalities of treatment for pulmonary arterial hypertension | Journal of the American College of Cardiology | 2004 | 194 |
| 28 | Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia | Journal of Experimental Medicine | 2007 | 184 |
| 29 | The Relationship Between School Absence, Academic Performance, and Asthma Status | Journal of School Health | 2008 | 174 |
| 30 | A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilator-associated pneumonia | Critical Care | 2012 | 173 |
| 31 | Prognostic Models for Selecting Patients With Acute Pulmonary Embolism for Initial Outpatient Therapy | Chest | 2007 | 168 |
| 32 | The Epidemiology and Pathogenesis and Treatment of Pseudomonas aeruginosa Infections: An Update | Drugs | 2021 | 161 |
| 33 | Treatment-related risk factors for hospital mortality in Candida bloodstream infections* | Critical Care Medicine | 2008 | 158 |
| 34 | Lung transplant referral for individuals with cystic fibrosis: Cystic Fibrosis Foundation consensus guidelines | Journal of Cystic Fibrosis | 2019 | 154 |
| 35 | Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection | Science Immunology | 2021 | 153 |
| 36 | Acute antibody-mediated rejection after lung transplantation | Journal of Heart and Lung Transplantation | 2013 | 150 |
| 37 | Safety and Efficacy of Remimazolam Compared With Placebo and Midazolam for Moderate Sedation During Bronchoscopy | Chest | 2019 | 150 |
| 38 | Circadian rhythm reprogramming during lung inflammation | Nature Communications | 2014 | 147 |
| 39 | Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms | ELife | 2016 | 145 |
| 40 | Modulation of Th1 Activation and Inflammation by the NF- B Repressor Foxj1 | Science | 2004 | 139 |
| 41 | Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens | Journal of Clinical Investigation | 2012 | 134 |
| 42 | Late Primary Graft Dysfunction After Lung Transplantation and Bronchiolitis Obliterans Syndrome | American Journal of Transplantation | 2008 | 132 |
| 43 | Short- vs Long-Duration Antibiotic Regimens for Ventilator-Associated Pneumonia | Chest | 2013 | 127 |
| 44 | Fluid balance and cardiac function in septic shock as predictors of hospital mortality | Critical Care | 2013 | 123 |
| 45 | Long-term Safety and Efficacy of Reslizumab in Patients with Eosinophilic Asthma | Journal of Allergy and Clinical Immunology: in Practice | 2017 | 116 |
| 46 | Duration of Exposure to Antipseudomonal β‐Lactam Antibiotics in the Critically Ill and Development of New Resistance | Pharmacotherapy | 2019 | 116 |
| 47 | The Impact of Comorbidity on Mortality Following In-hospital Diagnosis of Tuberculosis | Chest | 1998 | 115 |
| 48 | BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes | Mucosal Immunology | 2018 | 115 |
| 49 | Chemosensory Functions for Pulmonary Neuroendocrine Cells | American Journal of Respiratory Cell and Molecular Biology | 2014 | 113 |
| 50 | Lymphoproliferative disease after lung transplantation: comparison of presentation and outcome of early and late cases | Journal of Heart and Lung Transplantation | 2001 | 112 |
