| # | Title | Journal | Year | Citations |
|---|
| 1 | Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death | Nature | 1990 | 3,662 |
| 2 | Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice | Science | 2013 | 3,006 |
| 3 | Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL | Cell | 1996 | 2,444 |
| 4 | The Composite International Diagnostic Interview | Archives of General Psychiatry | 1988 | 2,340 |
| 5 | Mechanisms underlying the resistance to diet-induced obesity in germ-free mice | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 2,197 |
| 6 | Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death | Cell | 1995 | 2,013 |
| 7 | A framework for advancing our understanding of cancer-associated fibroblasts | Nature Reviews Cancer | 2020 | 2,012 |
| 8 | Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair | Cell | 1993 | 1,872 |
| 9 | Radioimmunoassay for Cyclic Nucleotides | Journal of Biological Chemistry | 1972 | 1,818 |
| 10 | Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations* | Endocrine Reviews | 1989 | 1,729 |
| 11 | Renal cell carcinoma | Nature Reviews Disease Primers | 2017 | 1,727 |
| 12 | Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease | Science | 2010 | 1,704 |
| 13 | Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody | Nature | 2020 | 1,695 |
| 14 | BCL-2 FAMILY: Regulators of Cell Death | Annual Review of Immunology | 1998 | 1,575 |
| 15 | BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 1,510 |
| 16 | Association of Depression and Diabetes Complications: A Meta-Analysis | Psychosomatic Medicine | 2001 | 1,440 |
| 17 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 18 | Proteogenomics connects somatic mutations to signalling in breast cancer | Nature | 2016 | 1,384 |
| 19 | Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine | Cell | 1996 | 1,339 |
| 20 | Molecular thanatopsis: a discourse on the BCL2 family and cell death | Blood | 1996 | 1,316 |
| 21 | Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure | JAMA - Journal of the American Medical Association | 2011 | 1,311 |
| 22 | Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41 | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 1,279 |
| 23 | DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome | Nature | 2008 | 1,275 |
| 24 | BIOCHEMISTRY AND GENETICS OF VON WILLEBRAND FACTOR | Annual Review of Biochemistry | 1998 | 1,249 |
| 25 | bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes | Cell | 1991 | 1,210 |
| 26 | Origin and Functions of Tissue Macrophages | Immunity | 2014 | 1,191 |
| 27 | Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014 | JAMA - Journal of the American Medical Association | 2017 | 1,180 |
| 28 | Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. | Journal of Clinical Investigation | 1994 | 1,158 |
| 29 | The surgical treatment of atrial fibrillation | Journal of Thoracic and Cardiovascular Surgery | 1991 | 1,141 |
| 30 | A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells | Science | 2015 | 1,139 |
| 31 | Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation | Immunity | 2014 | 1,120 |
| 32 | Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis | Journal of Clinical Investigation | 2000 | 1,120 |
| 33 | CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance | Nature | 2013 | 1,119 |
| 34 | Epidemiology of Diabetes and Diabetes-Related Complications | Physical Therapy | 2008 | 1,107 |
| 35 | Amoebiasis | Lancet, The | 2003 | 1,089 |
| 36 | Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study | Lancet Oncology, The | 2010 | 1,075 |
| 37 | Cancer to bone: a fatal attraction | Nature Reviews Cancer | 2011 | 1,047 |
| 38 | Structure and Function of the Mannose 6-Phosphate/Insulinlike Growth Factor II Receptors | Annual Review of Biochemistry | 1992 | 1,039 |
| 39 | CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models | Cancer Research | 2014 | 1,030 |
| 40 | Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 1,013 |
| 41 | Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma | New England Journal of Medicine | 2021 | 961 |
| 42 | Potently neutralizing and protective human antibodies against SARS-CoV-2 | Nature | 2020 | 956 |
| 43 | Sex and gender: modifiers of health, disease, and medicine | Lancet, The | 2020 | 955 |
| 44 | Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation | Cell Metabolism | 2016 | 944 |
| 45 | Transfusion Medicine — Blood Transfusion | New England Journal of Medicine | 1999 | 935 |
| 46 | Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas | Nature Genetics | 2016 | 933 |
| 47 | The Use of Continuous IV Sedation Is Associated With Prolongation of Mechanical Ventilation | Chest | 1998 | 920 |
| 48 | Peripheral education of the immune system by colonic commensal microbiota | Nature | 2011 | 920 |
| 49 | Rb Interacts with Histone Deacetylase to Repress Transcription | Cell | 1998 | 917 |
| 50 | Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1 | FASEB Journal | 2002 | 857 |
