| # | Title | Journal | Year | Citations |
|---|
| 1 | Effects of Estrogen Replacement on the Progression of Coronary-Artery Atherosclerosis | New England Journal of Medicine | 2000 | 1,186 |
| 2 | The Influence of CCL3L1 Gene-Containing Segmental Duplications on HIV-1/AIDS Susceptibility | Science | 2005 | 1,040 |
| 3 | Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years | JAMA - Journal of the American Medical Association | 2016 | 991 |
| 4 | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility | Nature Genetics | 2014 | 959 |
| 5 | Pharmacological Treatment of Neuropsychiatric Symptoms of Dementia | JAMA - Journal of the American Medical Association | 2005 | 803 |
| 6 | International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology | Lancet, The | 2015 | 780 |
| 7 | The prognostic significance of passing a daily screen of weaning parameters | Intensive Care Medicine | 1999 | 615 |
| 8 | Excessive Loss of Skeletal Muscle Mass in Older Adults With Type 2 Diabetes | Diabetes Care | 2009 | 593 |
| 9 | Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix | Osteoarthritis and Cartilage | 2009 | 531 |
| 10 | Heart Failure Prevalence, Incidence, and Mortality in the Elderly With Diabetes | Diabetes Care | 2004 | 488 |
| 11 | A Fetal Fatty-Acid Oxidation Disorder as a Cause of Liver Disease in Pregnant Women | New England Journal of Medicine | 1999 | 475 |
| 12 | Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology | Journal of Allergy and Clinical Immunology | 2013 | 470 |
| 13 | Why is osteoarthritis an age-related disease? | Best Practice and Research in Clinical Rheumatology | 2010 | 436 |
| 14 | Loss-of-function mutations in SLC30A8 protect against type 2 diabetes | Nature Genetics | 2014 | 428 |
| 15 | Effect of exercise training on chronic inflammation | Clinica Chimica Acta | 2010 | 414 |
| 16 | Abnormal angiogenesis in diabetes mellitus | Medicinal Research Reviews | 2003 | 406 |
| 17 | Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1 | Journal of Biological Chemistry | 2010 | 374 |
| 18 | Rhinitis and sinusitis | Journal of Allergy and Clinical Immunology | 2010 | 360 |
| 19 | The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study | BMJ: British Medical Journal | 2010 | 359 |
| 20 | Estrogen-Receptor Polymorphisms and Effects of Estrogen Replacement on High-Density Lipoprotein Cholesterol in Women with Coronary Disease | New England Journal of Medicine | 2002 | 352 |
| 21 | Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse | Journal of Clinical Investigation | 2003 | 345 |
| 22 | The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter | Journal of Biological Chemistry | 2005 | 329 |
| 23 | Cognitive Function, Gait Speed Decline, and Comorbidities: The Health, Aging and Body Composition Study | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2007 | 321 |
| 24 | Characteristics of sudden death in hemodialysis patients | Kidney International | 2006 | 318 |
| 25 | Effect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults | JAMA - Journal of the American Medical Association | 2015 | 318 |
| 26 | Low to Moderate Dose Anthracycline-Based Chemotherapy Is Associated With Early Noninvasive Imaging Evidence of Subclinical Cardiovascular Disease | JACC: Cardiovascular Imaging | 2013 | 316 |
| 27 | Common Estrogen Receptor Polymorphism Augments Effects of Hormone Replacement Therapy on E-Selectin but Not C-Reactive Protein | Circulation | 2002 | 314 |
| 28 | Association Between Vitamin D Status and Physical Performance: The InCHIANTI Study | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2007 | 314 |
| 29 | The Developmentally Regulatedalb1Gene ofAspergillus fumigatus: Its Role in Modulation of Conidial Morphology and Virulence | Journal of Bacteriology | 1998 | 312 |
| 30 | Integrated omics: tools, advances and future approaches | Journal of Molecular Endocrinology | 2019 | 301 |
| 31 | Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study | Lancet, The | 2002 | 297 |
| 32 | NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response | Journal of Biological Chemistry | 2012 | 293 |
| 33 | Targeted Deletion of the Ileal Bile Acid Transporter Eliminates Enterohepatic Cycling of Bile Acids in Mice | Journal of Biological Chemistry | 2003 | 288 |
| 34 | Comparison of glycated albumin and hemoglobin A1c levels in diabetic subjects on hemodialysis | Kidney International | 2008 | 284 |
| 35 | A DNA methylation biomarker of alcohol consumption | Molecular Psychiatry | 2018 | 280 |
| 36 | Organismal Differences in Post-translational Modifications in Histones H3 and H4 | Journal of Biological Chemistry | 2007 | 267 |
| 37 | Physical Rehabilitation for Older Patients Hospitalized for Heart Failure | New England Journal of Medicine | 2021 | 267 |
| 38 | Large Scale Implementation of a Respiratory Therapist– driven Protocol for Ventilator Weaning | American Journal of Respiratory and Critical Care Medicine | 1999 | 258 |
| 39 | Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP) | Journal of Hypertension | 2000 | 258 |
| 40 | Sirtuins Link Inflammation and Metabolism | Journal of Immunology Research | 2016 | 250 |
| 41 | The cardiovascular effects of erythropoietin | Cardiovascular Research | 2003 | 242 |
| 42 | Restorative yoga for women with breast cancer: findings from a randomized pilot study | Psycho-Oncology | 2009 | 230 |
| 43 | Evaluation of Subsecond Gated Helical CT for Quantification of Coronary Artery Calcium and Comparison with Electron Beam CT | American Journal of Roentgenology | 2000 | 227 |
| 44 | NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance | Journal of Biological Chemistry | 2011 | 223 |
| 45 | Executive Function, Memory, and Gait Speed Decline in Well-Functioning Older Adults | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2010 | 220 |
| 46 | Body Fat Distribution and Inflammation Among Obese Older Adults With and Without Metabolic Syndrome | Obesity | 2010 | 217 |
| 47 | Aging and osteoarthritis | Current Opinion in Rheumatology | 2011 | 212 |
| 48 | Genetic associations in diabetic nephropathy: a meta-analysis | Diabetologia | 2011 | 208 |
| 49 | Pseudallescheria boydii Brain Abscess Successfully Treated with Voriconazole and Surgical Drainage: Case Report and Literature Review of Central Nervous System Pseudallescheriasis | Clinical Infectious Diseases | 2000 | 206 |
| 50 | Arterial calcification: A review of mechanisms, animal models, and the prospects for therapy | Medicinal Research Reviews | 2001 | 205 |
