| # | Title | Journal | Year | Citations |
|---|
| 1 | Host-Gut Microbiota Metabolic Interactions | Science | 2012 | 3,693 |
| 2 | Gut microbiota functions: metabolism of nutrients and other food components | European Journal of Nutrition | 2018 | 1,608 |
| 3 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial | Lancet, The | 2010 | 1,483 |
| 4 | International evaluation of an AI system for breast cancer screening | Nature | 2020 | 1,458 |
| 5 | A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice | Nature Medicine | 2017 | 1,451 |
| 6 | Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology | Gut | 2016 | 1,379 |
| 7 | Colorectal cancer | Lancet, The | 2010 | 1,318 |
| 8 | Whole–genome characterization of chemoresistant ovarian cancer | Nature | 2015 | 1,206 |
| 9 | Cholangiocarcinoma 2020: the next horizon in mechanisms and management | Nature Reviews Gastroenterology and Hepatology | 2020 | 1,155 |
| 10 | Baricitinib as potential treatment for 2019-nCoV acute respiratory disease | Lancet, The | 2020 | 1,147 |
| 11 | Systematic review of the application of the plan–do–study–act method to improve quality in healthcare | BMJ Quality and Safety | 2014 | 1,082 |
| 12 | Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor | Science | 2013 | 1,012 |
| 13 | Impact of the gut microbiota on inflammation, obesity, and metabolic disease | Genome Medicine | 2016 | 1,000 |
| 14 | COVID-19: combining antiviral and anti-inflammatory treatments | Lancet Infectious Diseases, The | 2020 | 915 |
| 15 | Global metabolic profiling procedures for urine using UPLC–MS | Nature Protocols | 2010 | 867 |
| 16 | Neuropathic pain: an updated grading system for research and clinical practice | Pain | 2016 | 824 |
| 17 | Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination | Development (Cambridge) | 2016 | 803 |
| 18 | Prevalence of chronic pain in the UK: a systematic review and meta-analysis of population studies | BMJ Open | 2016 | 793 |
| 19 | Imaging biomarker roadmap for cancer studies | Nature Reviews Clinical Oncology | 2017 | 792 |
| 20 | Global metabolic profiling of animal and human tissues via UPLC-MS | Nature Protocols | 2013 | 774 |
| 21 | Eleven grand challenges in single-cell data science | Genome Biology | 2020 | 742 |
| 22 | ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment | Journal of Crohn's and Colitis | 2020 | 741 |
| 23 | Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4 | Immunity | 2014 | 708 |
| 24 | ESMO–ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease | Annals of Oncology | 2019 | 665 |
| 25 | Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial | Nature Medicine | 2018 | 649 |
| 26 | The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care | Nature Medicine | 2018 | 629 |
| 27 | Systemic gut microbial modulation of bile acid metabolism in host tissue compartments | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 625 |
| 28 | A strategy for human factors/ergonomics: developing the discipline and profession | Ergonomics | 2012 | 607 |
| 29 | Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress | Cancer Cell | 2015 | 596 |
| 30 | From tokenism to empowerment: progressing patient and public involvement in healthcare improvement | BMJ Quality and Safety | 2016 | 591 |
| 31 | Preparing for Precision Medicine | New England Journal of Medicine | 2012 | 579 |
| 32 | The IASP classification of chronic pain for ICD-11: chronic neuropathic pain | Pain | 2019 | 571 |
| 33 | Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial | Lancet, The | 2016 | 563 |
| 34 | Forkhead box proteins: tuning forks for transcriptional harmony | Nature Reviews Cancer | 2013 | 553 |
| 35 | Gut microbiome-host interactions in health and disease | Genome Medicine | 2011 | 550 |
| 36 | The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents | International Journal of Obesity | 2015 | 549 |
| 37 | Adiposity and cancer at major anatomical sites: umbrella review of the literature | BMJ: British Medical Journal | 2017 | 539 |
| 38 | Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study | Lancet Infectious Diseases, The | 2017 | 522 |
| 39 | Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies | Metabolomics | 2018 | 517 |
| 40 | Artificial intelligence versus clinicians: systematic review of design, reporting standards, and claims of deep learning studies | BMJ, The | 2020 | 509 |
| 41 | Do we need a third mechanistic descriptor for chronic pain states? | Pain | 2016 | 502 |
| 42 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 43 | Intraoperative Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry | Science Translational Medicine | 2013 | 488 |
| 44 | ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment | Journal of Crohn's and Colitis | 2020 | 478 |
| 45 | Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women | Nature Medicine | 2018 | 465 |
| 46 | Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles | Pain | 2017 | 462 |
| 47 | Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock | JAMA - Journal of the American Medical Association | 2016 | 456 |
| 48 | First Human Imaging Studies with the EXPLORER Total-Body PET Scanner* | Journal of Nuclear Medicine | 2019 | 453 |
| 49 | Understanding the role of gut microbiome–host metabolic signal disruption in health and disease | Trends in Microbiology | 2011 | 452 |
| 50 | Liquid chromatography–mass spectrometry based global metabolite profiling: A review | Analytica Chimica Acta | 2012 | 452 |
