# | Title | Journal | Year | Citations |
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1 | An improved cyan fluorescent protein variant useful for FRET | Nature Biotechnology | 2004 | 1,025 |
2 | Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1α-Mediated NF-κB Activation and Down-Regulation of TRAF2 Expression | Molecular and Cellular Biology | 2006 | 662 |
3 | Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2 | Nature Genetics | 2000 | 564 |
4 | FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction | Cell Metabolism | 2005 | 521 |
5 | Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny | Development (Cambridge) | 1995 | 500 |
6 | Cafeteria Diet Is a Robust Model of Human Metabolic Syndrome With Liver and Adipose Inflammation: Comparison to High‐Fat Diet | Obesity | 2011 | 467 |
7 | Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro | American Journal of Cardiology | 1999 | 466 |
8 | Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance | Nature Medicine | 2007 | 459 |
9 | Electron microscopy of whole cells in liquid with nanometer resolution | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 442 |
10 | Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 424 |
11 | Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance | Nature Medicine | 2004 | 414 |
12 | Pancreatic Islet Production of Vascular Endothelial Growth Factor-A Is Essential for Islet Vascularization, Revascularization, and Function | Diabetes | 2006 | 386 |
13 | Prevention of Obesity and Insulin Resistance in Mice Lacking Plasminogen Activator Inhibitor 1 | Diabetes | 2004 | 375 |
14 | Reduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion | Journal of Biological Chemistry | 2002 | 347 |
15 | Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program | Cell Metabolism | 2014 | 325 |
16 | Mechanism and Regulation of Calcium/Calmodulin-dependent Protein Kinase II Targeting to the NR2B Subunit of the N-Methyl-d-aspartate Receptor | Journal of Biological Chemistry | 2000 | 308 |
17 | Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 306 |
18 | Molecular architecture of human prion protein amyloid: A parallel, in-register β-structure | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 302 |
19 | TBP-associated factors are not generally required for transcriptional activation in yeast | Nature | 1996 | 300 |
20 | Members of the Large Maf Transcription Family Regulate Insulin Gene Transcription in Islet β Cells | Molecular and Cellular Biology | 2003 | 279 |
21 | Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene | Hippocampus | 2002 | 274 |
22 | Translocation of Autophosphorylated Calcium/Calmodulin-dependent Protein Kinase II to the Postsynaptic Density | Journal of Biological Chemistry | 1997 | 273 |
23 | Direct Effect of Cholesterol on Insulin Secretion | Diabetes | 2007 | 260 |
24 | Three‐dimensionally resolved NAD(P)H cellular metabolic redox imaging of the in situ cornea with two‐photon excitation laser scanning microscopy | Journal of Microscopy | 1995 | 251 |
25 | Total insulin and IGF-I resistance in pancreatic β cells causes overt diabetes | Nature Genetics | 2006 | 239 |
26 | Mitochondrial DNA G10398A Polymorphism and Invasive Breast Cancer in African-American Women | Cancer Research | 2005 | 237 |
27 | Neuronal Pathway from the Liver Modulates Energy Expenditure and Systemic Insulin Sensitivity | Science | 2006 | 233 |
28 | Genetics, statistics and human disease: analytical retooling for complexity | Trends in Genetics | 2004 | 230 |
29 | Intraislet Endothelial Cells Contribute to Revascularization of Transplanted Pancreatic Islets | Diabetes | 2004 | 228 |
30 | MafB is required for islet β cell maturation | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 223 |
31 | Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids | Journal of Biological Chemistry | 1993 | 218 |
32 | Chronic Treatment With Sildenafil Improves Energy Balance and Insulin Action in High Fat-Fed Conscious Mice | Diabetes | 2007 | 208 |
33 | A Primary Culture System for Functional Analysis of C. elegans Neurons and Muscle Cells | Neuron | 2002 | 202 |
34 | Cell integrins: commonly used receptors for diverse viral pathogens | Trends in Microbiology | 2007 | 199 |
35 | Human and Helicobacter pylori coevolution shapes the risk of gastric disease | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 198 |
36 | Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye | Journal of Cell Biology | 2004 | 192 |
37 | Oxidative Stress-mediated, Post-translational Loss of MafA Protein as a Contributing Mechanism to Loss of Insulin Gene Expression in Glucotoxic Beta Cells | Journal of Biological Chemistry | 2005 | 192 |
38 | Regulation of the Insulin Gene by Glucose and Fatty Acids | Journal of Nutrition | 2006 | 192 |
39 | Large Scale Comparison of Gene Expression Levels by Microarrays and RNAseq Using TCGA Data | PLoS ONE | 2013 | 189 |
40 | MafA and MafB activity in pancreatic β cells | Trends in Endocrinology and Metabolism | 2011 | 187 |
41 | Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice | Neurobiology of Learning and Memory | 2006 | 183 |
42 | Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters | Nature Structural and Molecular Biology | 2010 | 183 |
43 | Specific high-affinity binding protein for human corticotropin-releasing hormone in normal human plasma | Biochemical and Biophysical Research Communications | 1987 | 181 |
44 | MafB | Diabetes | 2006 | 178 |
45 | Islet Microenvironment, Modulated by Vascular Endothelial Growth Factor-A Signaling, Promotes β Cell Regeneration | Cell Metabolism | 2014 | 177 |
46 | TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes | Nature Medicine | 2006 | 168 |
47 | pdx-1 function is specifically required in embryonic β cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis | Developmental Biology | 2008 | 165 |
48 | Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins. | Molecular and Cellular Biology | 1991 | 164 |
49 | Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas | Genesis | 2000 | 163 |
50 | The WD40 Repeat Protein WDR-23 Functions with the CUL4/DDB1 Ubiquitin Ligase To Regulate Nuclear Abundance and Activity of SKN-1 inCaenorhabditis elegans | Molecular and Cellular Biology | 2009 | 161 |