# | Title | Journal | Year | Citations |
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1 | A comprehensive classification system for lipids | Journal of Lipid Research | 2005 | 1,348 |
2 | The Nature of the Arrestin·Receptor Complex Determines the Ultimate Fate of the Internalized Receptor | Journal of Biological Chemistry | 2003 | 1,245 |
3 | Molecular mechanism for an inherited cardiac arrhythmia | Nature | 1995 | 919 |
4 | The primary structure of a plasma membrane guanylate cyclase demonstrates diversity within this new receptor family | Cell | 1989 | 553 |
5 | Drug and Bile Acid Transporters in Rosuvastatin Hepatic Uptake: Function, Expression, and Pharmacogenetics | Gastroenterology | 2006 | 542 |
6 | Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator | Science | 2014 | 476 |
7 | A transient placental source of serotonin for the fetal forebrain | Nature | 2011 | 475 |
8 | The structural basis of arrestin-mediated regulation of G-protein-coupled receptors | | 2006 | 404 |
9 | Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease | Progress in Neurobiology | 2015 | 379 |
10 | Requirement of Type III TGF- Receptor for Endocardial Cell Transformation in the Heart | Science | 1999 | 361 |
11 | Hyperactivity and Intact Hippocampus-Dependent Learning in Mice Lacking the M1Muscarinic Acetylcholine Receptor | Journal of Neuroscience | 2001 | 344 |
12 | Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human α-synuclein | Journal of Neurochemistry | 2004 | 328 |
13 | The molecular acrobatics of arrestin activation | Trends in Pharmacological Sciences | 2004 | 327 |
14 | Metabotropic glutamate receptors in the basal ganglia motor circuit | Nature Reviews Neuroscience | 2005 | 297 |
15 | Loss of GluN2B-Containing NMDA Receptors in CA1 Hippocampus and Cortex Impairs Long-Term Depression, Reduces Dendritic Spine Density, and Disrupts Learning | Journal of Neuroscience | 2010 | 281 |
16 | The multifaceted role of fibrinogen in tissue injury and inflammation | Blood | 2019 | 279 |
17 | Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDL Receptor–Deficient Mice | Circulation | 2002 | 278 |
18 | A Dialogue between the Immune System and Brain, Spoken in the Language of Serotonin | ACS Chemical Neuroscience | 2013 | 260 |
19 | 15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Colorectal Cancer | Journal of Biological Chemistry | 2005 | 242 |
20 | Macrophages, inflammation, and atherosclerosis | International Journal of Obesity | 2003 | 229 |
21 | Molecular Basis of Fertilization | Annual Review of Biochemistry | 1989 | 226 |
22 | Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders | Nature Reviews Drug Discovery | 2014 | 226 |
23 | Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter | Journal of Comparative Neurology | 2000 | 225 |
24 | Novel Selective Allosteric Activator of the M1Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats | Journal of Neuroscience | 2008 | 219 |
25 | Drugs for Allosteric Sites on Receptors | Annual Review of Pharmacology and Toxicology | 2014 | 218 |
26 | A Selective Allosteric Potentiator of the M1Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal Learning | Journal of Neuroscience | 2009 | 217 |
27 | The F2-isoprostane, 8-epi-prostaglandin F2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist | Prostaglandins | 1992 | 214 |
28 | Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery | Journal of Medicinal Chemistry | 2012 | 212 |
29 | The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders | Journal of Clinical Investigation | 2009 | 203 |
30 | A Primary Culture System for Functional Analysis of C. elegans Neurons and Muscle Cells | Neuron | 2002 | 202 |
31 | mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning | Neuropsychopharmacology | 2009 | 199 |
32 | How activated receptors couple to G proteins | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 196 |
33 | MEMBRANETRAFFICKING OFG PROTEIN–COUPLEDRECEPTORS | Annual Review of Pharmacology and Toxicology | 2004 | 194 |
34 | How and why do GPCRs dimerize? | Trends in Pharmacological Sciences | 2008 | 192 |
35 | Role of Astrocytes in Brain Function and Disease | Toxicologic Pathology | 2011 | 192 |
36 | GPCR monomers and oligomers: it takes all kinds | Trends in Neurosciences | 2008 | 187 |
37 | Enhanced Arrestin Facilitates Recovery and Protects Rods Lacking Rhodopsin Phosphorylation | Current Biology | 2009 | 178 |
38 | Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease | Journal of Medicinal Chemistry | 2013 | 178 |
39 | Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats | Journal of Pharmacology and Experimental Therapeutics | 2008 | 177 |
40 | Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity | Molecular Pharmacology | 2010 | 176 |
41 | Functional Selectivity of G Protein Signaling by Agonist Peptides and Thrombin for the Protease-activated Receptor-1* | Journal of Biological Chemistry | 2005 | 173 |
42 | Brain Regional Quantification of F-Ring and D-/E-Ring Isoprostanes and Neuroprostanes in Alzheimer’s Disease | American Journal of Pathology | 2001 | 167 |
43 | Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Bα subunit | Biochemical Journal | 1999 | 165 |
44 | A Selective Allosteric Potentiator of Metabotropic Glutamate (mGlu) 2 Receptors Has Effects Similar to an Orthosteric mGlu2/3 Receptor Agonist in Mouse Models Predictive of Antipsychotic Activity | Journal of Pharmacology and Experimental Therapeutics | 2005 | 165 |
45 | Phenotype risk scores identify patients with unrecognized Mendelian disease patterns | Science | 2018 | 164 |
46 | Biphenyl-indanone A, a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor Subtype 2, Has Antipsychotic- and Anxiolytic-Like Effects in Mice | Journal of Pharmacology and Experimental Therapeutics | 2006 | 162 |
47 | Bone Morphogenetic Proteins Signal through the Transforming Growth Factor-β Type III Receptor | Journal of Biological Chemistry | 2008 | 161 |
48 | Oscillatory Ca2+ Signaling in the Isolated Caenorhabditis elegans Intestine | Journal of General Physiology | 2005 | 158 |
49 | Tyr-95 and Ile-172 in Transmembrane Segments 1 and 3 of Human Serotonin Transporters Interact to Establish High Affinity Recognition of Antidepressants | Journal of Biological Chemistry | 2006 | 158 |
50 | Mechanism of potassium-channel selectivity revealed by Na+ and Li+ binding sites within the KcsA pore | Nature Structural and Molecular Biology | 2009 | 158 |